KF-1 ubiquitin ligase: An anxiety suppressor

Tamotsu Hashimoto-Gotoh, Naoyuki Iwabe, Atsushi Tsujimura, Keizo Takao, Tsuyoshi Miyakawa

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Anxiety is an instinct that may have developed to promote adaptive survival by evading unnecessary danger. However, excessive anxiety is disruptive and can be a basic disorder of other psychiatric diseases such as depression. The KF-1, a ubiquitin ligase located on the endoplasmic reticulum (ER), may prevent excessive anxiety; kf-1-/- mice exhibit selectively elevated anxiety-like behavior against light or heights. It is surmised that KF-1 degrades some target proteins, responsible for promoting anxiety, through the ER-associated degradation pathway, similar to Parkin in Parkinson's disease (PD). Parkin, another ER-ubiquitin ligase, prevents the degeneration of dopaminergic neurons by degrading the target proteins responsible for PD. Molecular phylogenetic studies have revealed that the prototype of kf-1 appeared in the very early phase of animal evolution but was lost, unlike parkin, in the lineage leading up to Drosophila. Therefore, kf-1-/- mice may be a powerful tool for elucidating the molecular mechanisms involved in emotional regulation, and for screening novel anxiolytic/antidepressant compounds.

Original languageEnglish
Article numberArticle 1
JournalFrontiers in Neuroscience
Volume3
Issue numberMAY
DOIs
Publication statusPublished - 01-12-2009

Fingerprint

Ligases
Ubiquitin
Anxiety
Endoplasmic Reticulum
Parkinson Disease
Endoplasmic Reticulum-Associated Degradation
Instinct
Dopaminergic Neurons
Anti-Anxiety Agents
Antidepressive Agents
Drosophila
Psychiatry
Proteins
Depression
Light

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Hashimoto-Gotoh, T., Iwabe, N., Tsujimura, A., Takao, K., & Miyakawa, T. (2009). KF-1 ubiquitin ligase: An anxiety suppressor. Frontiers in Neuroscience, 3(MAY), [Article 1]. https://doi.org/10.3389/neuro.01.004.2009
Hashimoto-Gotoh, Tamotsu ; Iwabe, Naoyuki ; Tsujimura, Atsushi ; Takao, Keizo ; Miyakawa, Tsuyoshi. / KF-1 ubiquitin ligase : An anxiety suppressor. In: Frontiers in Neuroscience. 2009 ; Vol. 3, No. MAY.
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Hashimoto-Gotoh, T, Iwabe, N, Tsujimura, A, Takao, K & Miyakawa, T 2009, 'KF-1 ubiquitin ligase: An anxiety suppressor', Frontiers in Neuroscience, vol. 3, no. MAY, Article 1. https://doi.org/10.3389/neuro.01.004.2009

KF-1 ubiquitin ligase : An anxiety suppressor. / Hashimoto-Gotoh, Tamotsu; Iwabe, Naoyuki; Tsujimura, Atsushi; Takao, Keizo; Miyakawa, Tsuyoshi.

In: Frontiers in Neuroscience, Vol. 3, No. MAY, Article 1, 01.12.2009.

Research output: Contribution to journalReview article

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Hashimoto-Gotoh T, Iwabe N, Tsujimura A, Takao K, Miyakawa T. KF-1 ubiquitin ligase: An anxiety suppressor. Frontiers in Neuroscience. 2009 Dec 1;3(MAY). Article 1. https://doi.org/10.3389/neuro.01.004.2009