TY - JOUR
T1 - Kinetics of foveal cone photopigment in myopia without chorioretinal degeneration
AU - Horio, Naoichi
AU - Miyake, Yozo
AU - Horiguchi, Masayuki
N1 - Funding Information:
This study was supported by grants for Retinochoroidal Atrophy Research (Nos. 62480362, 02670784) from the Ministry of Education, Science, Sports and Culture, Japan, and by a special grant for Retinochoroidal Atrophy Research from the Ministry of Health and Welfare, Japan.
PY - 1999/1
Y1 - 1999/1
N2 - Purpose: To study the early changes in the outer retina of myopic eyes, we performed fundus reflection foveal cone densitometry in 45 subjects with normal visual acuity and no chorioretinal degeneration (ages: 18-47 years, refraction; +2.0014.50 diopters). Methods: After full bleaching, the density of the photopigment was measured for 7 minutes by using a test spot, 562 nm in wavelength and 1°in diameter, focused on the fovea. We calculated the density difference (DD) and the time constant (TC) of photopigment regeneration. Results: Although we found no correlation between the DD and the refractive error, there was a significant increase in TC as the refractive error increased (r = 0.50, P < 0.01). Conclusions: These findings indicated that the kinetics of cone pigments become abnormal preceding the loss of cone cells or chorioretinal degeneration in high myopia.
AB - Purpose: To study the early changes in the outer retina of myopic eyes, we performed fundus reflection foveal cone densitometry in 45 subjects with normal visual acuity and no chorioretinal degeneration (ages: 18-47 years, refraction; +2.0014.50 diopters). Methods: After full bleaching, the density of the photopigment was measured for 7 minutes by using a test spot, 562 nm in wavelength and 1°in diameter, focused on the fovea. We calculated the density difference (DD) and the time constant (TC) of photopigment regeneration. Results: Although we found no correlation between the DD and the refractive error, there was a significant increase in TC as the refractive error increased (r = 0.50, P < 0.01). Conclusions: These findings indicated that the kinetics of cone pigments become abnormal preceding the loss of cone cells or chorioretinal degeneration in high myopia.
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U2 - 10.1016/S0021-5155(98)00062-8
DO - 10.1016/S0021-5155(98)00062-8
M3 - Article
C2 - 10197742
AN - SCOPUS:0345390287
SN - 0021-5155
VL - 43
SP - 44
EP - 47
JO - Japanese Journal of Ophthalmology
JF - Japanese Journal of Ophthalmology
IS - 1
ER -