Kinetics of foveal cone photopigment in myopia without chorioretinal degeneration

Naoichi Horio, Yozo Miyake, Masayuki Horiguchi

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Purpose: To study the early changes in the outer retina of myopic eyes, we performed fundus reflection foveal cone densitometry in 45 subjects with normal visual acuity and no chorioretinal degeneration (ages: 18-47 years, refraction; +2.0014.50 diopters). Methods: After full bleaching, the density of the photopigment was measured for 7 minutes by using a test spot, 562 nm in wavelength and 1°in diameter, focused on the fovea. We calculated the density difference (DD) and the time constant (TC) of photopigment regeneration. Results: Although we found no correlation between the DD and the refractive error, there was a significant increase in TC as the refractive error increased (r = 0.50, P < 0.01). Conclusions: These findings indicated that the kinetics of cone pigments become abnormal preceding the loss of cone cells or chorioretinal degeneration in high myopia.

Original languageEnglish
Pages (from-to)44-47
Number of pages4
JournalJapanese Journal of Ophthalmology
Issue number1
Publication statusPublished - 01-1999
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Ophthalmology


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