KL-6 as a novel marker for activities of interstitial pneumonia in connective tissue diseases

S. Fukaya, H. Oshima, K. Kato, Y. Komatsu, H. Matsumura, K. Ishii, H. Miyama, T. Nagai, I. Tanaka, A. Mizutani, M. Katayama, S. Yoshida, K. Torikai

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The objective of this study was to determine the role of serum KL-6 levels as a marker for the activity of interstitial pneumonia in patients with connective tissue diseases. The serum concentrations of KL-6, a glycoprotein produced mainly by pulmonary type II epithelial cells, were measured in 21 patients with connective tissue disease. The activity of interstitial pneumonia was compared with the associated serum KL-6 concentrations. Serum KL-6 concentrations in patients with interstitial pneumonia were significantly higher than those in the controls. Among patients with active interstitial pneumonia, serum KL-6 concentrations following the treatment (after improvement) were significantly lower than the pretreatment values. The extent of the pulmonary fibrosis correlated positively with the serum KL-6 concentrations during the inactive phase of the interstitial pneumonia. These results suggest that sequential measurement of serum KL-6 levels is a new and useful means for the evaluation of interstitial pneumonia in patients with connective tissue diseases.

Original languageEnglish
Pages (from-to)223-225
Number of pages3
JournalRheumatology International
Volume19
Issue number6
DOIs
Publication statusPublished - 2000

All Science Journal Classification (ASJC) codes

  • Rheumatology
  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'KL-6 as a novel marker for activities of interstitial pneumonia in connective tissue diseases'. Together they form a unique fingerprint.

  • Cite this

    Fukaya, S., Oshima, H., Kato, K., Komatsu, Y., Matsumura, H., Ishii, K., Miyama, H., Nagai, T., Tanaka, I., Mizutani, A., Katayama, M., Yoshida, S., & Torikai, K. (2000). KL-6 as a novel marker for activities of interstitial pneumonia in connective tissue diseases. Rheumatology International, 19(6), 223-225. https://doi.org/10.1007/s002960000064