Abstract
The objective of this study was to determine the role of serum KL-6 levels as a marker for the activity of interstitial pneumonia in patients with connective tissue diseases. The serum concentrations of KL-6, a glycoprotein produced mainly by pulmonary type II epithelial cells, were measured in 21 patients with connective tissue disease. The activity of interstitial pneumonia was compared with the associated serum KL-6 concentrations. Serum KL-6 concentrations in patients with interstitial pneumonia were significantly higher than those in the controls. Among patients with active interstitial pneumonia, serum KL-6 concentrations following the treatment (after improvement) were significantly lower than the pretreatment values. The extent of the pulmonary fibrosis correlated positively with the serum KL-6 concentrations during the inactive phase of the interstitial pneumonia. These results suggest that sequential measurement of serum KL-6 levels is a new and useful means for the evaluation of interstitial pneumonia in patients with connective tissue diseases.
| Original language | English |
|---|---|
| Pages (from-to) | 223-225 |
| Number of pages | 3 |
| Journal | Rheumatology International |
| Volume | 19 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2000 |
| Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Immunology and Allergy
- Rheumatology
- Immunology
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