Knockdown of DISC1 by In Utero Gene Transfer Disturbs Postnatal Dopaminergic Maturation in the Frontal Cortex and Leads to Adult Behavioral Deficits

Minae Niwa, Atsushi Kamiya, Rina Murai, Ken ichiro Kubo, Aaron J. Gruber, Kenji Tomita, Lingling Lu, Shuta Tomisato, Hanna Jaaro-Peled, Saurav Seshadri, Hideki Hiyama, Beverly Huang, Kazuhisa Kohda, Yukihiro Noda, Patricio O'Donnell, Kazunori Nakajima, Akira Sawa, Toshitaka Nabeshima

Research output: Contribution to journalArticle

198 Citations (Scopus)

Abstract

Adult brain function and behavior are influenced by neuronal network formation during development. Genetic susceptibility factors for adult psychiatric illnesses, such as Neuregulin-1 and Disrupted-in-Schizophrenia-1 (DISC1), influence adult high brain functions, including cognition and information processing. These factors have roles during neurodevelopment and are likely to cooperate, forming pathways or "signalosomes." Here we report the potential to generate an animal model via in utero gene transfer in order to address an important question of how nonlethal deficits in early development may affect postnatal brain maturation and high brain functions in adulthood, which are impaired in various psychiatric illnesses such as schizophrenia. We show that transient knockdown of DISC1 in the pre- and perinatal stages, specifically in a lineage of pyramidal neurons mainly in the prefrontal cortex, leads to selective abnormalities in postnatal mesocortical dopaminergic maturation and behavioral abnormalities associated with disturbed cortical neurocircuitry after puberty. PaperFlick: {An electronic component is presented}.

Original languageEnglish
Pages (from-to)480-489
Number of pages10
JournalNeuron
Volume65
Issue number4
DOIs
Publication statusPublished - 25-02-2010
Externally publishedYes

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Frontal Lobe
Schizophrenia
Brain
Genes
Psychiatry
Neuregulin-1
Pyramidal Cells
Genetic Predisposition to Disease
Puberty
Prefrontal Cortex
Automatic Data Processing
Cognition
Animal Models

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Niwa, Minae ; Kamiya, Atsushi ; Murai, Rina ; Kubo, Ken ichiro ; Gruber, Aaron J. ; Tomita, Kenji ; Lu, Lingling ; Tomisato, Shuta ; Jaaro-Peled, Hanna ; Seshadri, Saurav ; Hiyama, Hideki ; Huang, Beverly ; Kohda, Kazuhisa ; Noda, Yukihiro ; O'Donnell, Patricio ; Nakajima, Kazunori ; Sawa, Akira ; Nabeshima, Toshitaka. / Knockdown of DISC1 by In Utero Gene Transfer Disturbs Postnatal Dopaminergic Maturation in the Frontal Cortex and Leads to Adult Behavioral Deficits. In: Neuron. 2010 ; Vol. 65, No. 4. pp. 480-489.
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abstract = "Adult brain function and behavior are influenced by neuronal network formation during development. Genetic susceptibility factors for adult psychiatric illnesses, such as Neuregulin-1 and Disrupted-in-Schizophrenia-1 (DISC1), influence adult high brain functions, including cognition and information processing. These factors have roles during neurodevelopment and are likely to cooperate, forming pathways or {"}signalosomes.{"} Here we report the potential to generate an animal model via in utero gene transfer in order to address an important question of how nonlethal deficits in early development may affect postnatal brain maturation and high brain functions in adulthood, which are impaired in various psychiatric illnesses such as schizophrenia. We show that transient knockdown of DISC1 in the pre- and perinatal stages, specifically in a lineage of pyramidal neurons mainly in the prefrontal cortex, leads to selective abnormalities in postnatal mesocortical dopaminergic maturation and behavioral abnormalities associated with disturbed cortical neurocircuitry after puberty. PaperFlick: {An electronic component is presented}.",
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Niwa, M, Kamiya, A, Murai, R, Kubo, KI, Gruber, AJ, Tomita, K, Lu, L, Tomisato, S, Jaaro-Peled, H, Seshadri, S, Hiyama, H, Huang, B, Kohda, K, Noda, Y, O'Donnell, P, Nakajima, K, Sawa, A & Nabeshima, T 2010, 'Knockdown of DISC1 by In Utero Gene Transfer Disturbs Postnatal Dopaminergic Maturation in the Frontal Cortex and Leads to Adult Behavioral Deficits', Neuron, vol. 65, no. 4, pp. 480-489. https://doi.org/10.1016/j.neuron.2010.01.019

Knockdown of DISC1 by In Utero Gene Transfer Disturbs Postnatal Dopaminergic Maturation in the Frontal Cortex and Leads to Adult Behavioral Deficits. / Niwa, Minae; Kamiya, Atsushi; Murai, Rina; Kubo, Ken ichiro; Gruber, Aaron J.; Tomita, Kenji; Lu, Lingling; Tomisato, Shuta; Jaaro-Peled, Hanna; Seshadri, Saurav; Hiyama, Hideki; Huang, Beverly; Kohda, Kazuhisa; Noda, Yukihiro; O'Donnell, Patricio; Nakajima, Kazunori; Sawa, Akira; Nabeshima, Toshitaka.

In: Neuron, Vol. 65, No. 4, 25.02.2010, p. 480-489.

Research output: Contribution to journalArticle

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AU - Niwa, Minae

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AU - Murai, Rina

AU - Kubo, Ken ichiro

AU - Gruber, Aaron J.

AU - Tomita, Kenji

AU - Lu, Lingling

AU - Tomisato, Shuta

AU - Jaaro-Peled, Hanna

AU - Seshadri, Saurav

AU - Hiyama, Hideki

AU - Huang, Beverly

AU - Kohda, Kazuhisa

AU - Noda, Yukihiro

AU - O'Donnell, Patricio

AU - Nakajima, Kazunori

AU - Sawa, Akira

AU - Nabeshima, Toshitaka

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N2 - Adult brain function and behavior are influenced by neuronal network formation during development. Genetic susceptibility factors for adult psychiatric illnesses, such as Neuregulin-1 and Disrupted-in-Schizophrenia-1 (DISC1), influence adult high brain functions, including cognition and information processing. These factors have roles during neurodevelopment and are likely to cooperate, forming pathways or "signalosomes." Here we report the potential to generate an animal model via in utero gene transfer in order to address an important question of how nonlethal deficits in early development may affect postnatal brain maturation and high brain functions in adulthood, which are impaired in various psychiatric illnesses such as schizophrenia. We show that transient knockdown of DISC1 in the pre- and perinatal stages, specifically in a lineage of pyramidal neurons mainly in the prefrontal cortex, leads to selective abnormalities in postnatal mesocortical dopaminergic maturation and behavioral abnormalities associated with disturbed cortical neurocircuitry after puberty. PaperFlick: {An electronic component is presented}.

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