KPC-Producing klebsiella pneumoniae strains that harbor AAC(6')-

Derek N. Bremmer, Cornelius J. Clancy, Ellen G. Press, Reem Almaghrabi, Liang Chen, E. Yohei Doi, M. Hong Nguyen, Ryan K. Shieldsb

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

The aminoglycoside-modifying enzyme AAC(6')-Ib is common among carbapenem-resistant Klebsiella pneumoniae (CR-Kp) strains. We investigated amikacin (AMK) activity against 20 AAC(6')-Ib-producing CR-Kp strains. MICs clustered at 16 to 32 μg/ml. By the time-kill study, AMK (1× and 4×the MIC) was bactericidal against 30% and 85% of the strains, respectively. At achievable human serum concentrations, however, the majority of strains showed regrowth, suggesting that AAC(6')-Ib confers intermediate AMK resistance. AMK and trimethoprim-sulfamethoxazole (TMP-SMX) were synergistic against 90% of the strains, indicating that the combination may overcome resistance.

Original languageEnglish
Pages (from-to)7597-7600
Number of pages4
JournalAntimicrobial agents and chemotherapy
Volume58
Issue number12
DOIs
Publication statusPublished - 01-12-2014
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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