Kynurenine Pathway Metabolites in Cerebrospinal Fluid and Serum in Complex Partial Seizures

Melvyn P. Heyes, Kuniaki Saito, Orrin Devinsky, N. Suzan Nadi

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Summary: The kynurenine pathway metabolites, quinolinic acid (QUIN) and L‐kynurenine are convulsants, whereas kynurenic acid (KYNA) is an antagonist of excitatory amino acid receptors. Imbalances in the concentrations of these metabolites have been implicated in the etiology of human seizure disorders. In the present study, L‐kynurenine and QUIN concentrations in both cerebrospinal fluid (CSF) and serum were reduced in patients with intractable complex partial seizures (CPS) in both the postictal period (15–75 min after a seizure) and the interictal period (absence of seizure for >24 h) as compared with neurologically normal control subjects. Linear regression analyses and analysis of covariance showed that the reductions in serum QUIN and L‐kynurenine were correlated to blood antiepileptic medication. L‐Tryptophan (L‐TRP) levels also tended to be lower in both CSF and serum of the seizure patients. CSF KYNA and serum 3‐hydroxykynurenine concentrations were not affected in seizure patients, whereas serum levels of KYNA were reduced. 3‐Hydroxykynurenine was not detected in the CSF of either control or seizure patients. The results do not support a role for a generalized reduction in KYNA concentrations or an increased ratio of QUIN:KYNA, or increases in CSF L‐kynurenine in initiation and maintenance of intractable CPS humans.

Original languageEnglish
Pages (from-to)251-257
Number of pages7
JournalEpilepsia
Volume35
Issue number2
DOIs
Publication statusPublished - 01-01-1994
Externally publishedYes

Fingerprint

Kynurenine
Kynurenic Acid
Quinolinic Acid
Cerebrospinal Fluid
Seizures
Serum
Absence Epilepsy
Convulsants
Glutamate Receptors
Anticonvulsants
Linear Models
Epilepsy
Regression Analysis
Maintenance

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Heyes, Melvyn P. ; Saito, Kuniaki ; Devinsky, Orrin ; Nadi, N. Suzan. / Kynurenine Pathway Metabolites in Cerebrospinal Fluid and Serum in Complex Partial Seizures. In: Epilepsia. 1994 ; Vol. 35, No. 2. pp. 251-257.
@article{3f1e36cd3f3c468e94682ba47d3bb4f2,
title = "Kynurenine Pathway Metabolites in Cerebrospinal Fluid and Serum in Complex Partial Seizures",
abstract = "Summary: The kynurenine pathway metabolites, quinolinic acid (QUIN) and L‐kynurenine are convulsants, whereas kynurenic acid (KYNA) is an antagonist of excitatory amino acid receptors. Imbalances in the concentrations of these metabolites have been implicated in the etiology of human seizure disorders. In the present study, L‐kynurenine and QUIN concentrations in both cerebrospinal fluid (CSF) and serum were reduced in patients with intractable complex partial seizures (CPS) in both the postictal period (15–75 min after a seizure) and the interictal period (absence of seizure for >24 h) as compared with neurologically normal control subjects. Linear regression analyses and analysis of covariance showed that the reductions in serum QUIN and L‐kynurenine were correlated to blood antiepileptic medication. L‐Tryptophan (L‐TRP) levels also tended to be lower in both CSF and serum of the seizure patients. CSF KYNA and serum 3‐hydroxykynurenine concentrations were not affected in seizure patients, whereas serum levels of KYNA were reduced. 3‐Hydroxykynurenine was not detected in the CSF of either control or seizure patients. The results do not support a role for a generalized reduction in KYNA concentrations or an increased ratio of QUIN:KYNA, or increases in CSF L‐kynurenine in initiation and maintenance of intractable CPS humans.",
author = "Heyes, {Melvyn P.} and Kuniaki Saito and Orrin Devinsky and Nadi, {N. Suzan}",
year = "1994",
month = "1",
day = "1",
doi = "10.1111/j.1528-1157.1994.tb02428.x",
language = "English",
volume = "35",
pages = "251--257",
journal = "Epilepsia",
issn = "0013-9580",
publisher = "Wiley-Blackwell",
number = "2",

}

Kynurenine Pathway Metabolites in Cerebrospinal Fluid and Serum in Complex Partial Seizures. / Heyes, Melvyn P.; Saito, Kuniaki; Devinsky, Orrin; Nadi, N. Suzan.

In: Epilepsia, Vol. 35, No. 2, 01.01.1994, p. 251-257.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Kynurenine Pathway Metabolites in Cerebrospinal Fluid and Serum in Complex Partial Seizures

AU - Heyes, Melvyn P.

AU - Saito, Kuniaki

AU - Devinsky, Orrin

AU - Nadi, N. Suzan

PY - 1994/1/1

Y1 - 1994/1/1

N2 - Summary: The kynurenine pathway metabolites, quinolinic acid (QUIN) and L‐kynurenine are convulsants, whereas kynurenic acid (KYNA) is an antagonist of excitatory amino acid receptors. Imbalances in the concentrations of these metabolites have been implicated in the etiology of human seizure disorders. In the present study, L‐kynurenine and QUIN concentrations in both cerebrospinal fluid (CSF) and serum were reduced in patients with intractable complex partial seizures (CPS) in both the postictal period (15–75 min after a seizure) and the interictal period (absence of seizure for >24 h) as compared with neurologically normal control subjects. Linear regression analyses and analysis of covariance showed that the reductions in serum QUIN and L‐kynurenine were correlated to blood antiepileptic medication. L‐Tryptophan (L‐TRP) levels also tended to be lower in both CSF and serum of the seizure patients. CSF KYNA and serum 3‐hydroxykynurenine concentrations were not affected in seizure patients, whereas serum levels of KYNA were reduced. 3‐Hydroxykynurenine was not detected in the CSF of either control or seizure patients. The results do not support a role for a generalized reduction in KYNA concentrations or an increased ratio of QUIN:KYNA, or increases in CSF L‐kynurenine in initiation and maintenance of intractable CPS humans.

AB - Summary: The kynurenine pathway metabolites, quinolinic acid (QUIN) and L‐kynurenine are convulsants, whereas kynurenic acid (KYNA) is an antagonist of excitatory amino acid receptors. Imbalances in the concentrations of these metabolites have been implicated in the etiology of human seizure disorders. In the present study, L‐kynurenine and QUIN concentrations in both cerebrospinal fluid (CSF) and serum were reduced in patients with intractable complex partial seizures (CPS) in both the postictal period (15–75 min after a seizure) and the interictal period (absence of seizure for >24 h) as compared with neurologically normal control subjects. Linear regression analyses and analysis of covariance showed that the reductions in serum QUIN and L‐kynurenine were correlated to blood antiepileptic medication. L‐Tryptophan (L‐TRP) levels also tended to be lower in both CSF and serum of the seizure patients. CSF KYNA and serum 3‐hydroxykynurenine concentrations were not affected in seizure patients, whereas serum levels of KYNA were reduced. 3‐Hydroxykynurenine was not detected in the CSF of either control or seizure patients. The results do not support a role for a generalized reduction in KYNA concentrations or an increased ratio of QUIN:KYNA, or increases in CSF L‐kynurenine in initiation and maintenance of intractable CPS humans.

UR - http://www.scopus.com/inward/record.url?scp=0028348408&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028348408&partnerID=8YFLogxK

U2 - 10.1111/j.1528-1157.1994.tb02428.x

DO - 10.1111/j.1528-1157.1994.tb02428.x

M3 - Article

C2 - 8156942

AN - SCOPUS:0028348408

VL - 35

SP - 251

EP - 257

JO - Epilepsia

JF - Epilepsia

SN - 0013-9580

IS - 2

ER -