Kynurenine Pathway Metabolites in Cerebrospinal Fluid and Serum in Complex Partial Seizures

Melvyn P. Heyes, Kuniaki Saito, Orrin Devinsky, N. Suzan Nadi

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Summary: The kynurenine pathway metabolites, quinolinic acid (QUIN) and L‐kynurenine are convulsants, whereas kynurenic acid (KYNA) is an antagonist of excitatory amino acid receptors. Imbalances in the concentrations of these metabolites have been implicated in the etiology of human seizure disorders. In the present study, L‐kynurenine and QUIN concentrations in both cerebrospinal fluid (CSF) and serum were reduced in patients with intractable complex partial seizures (CPS) in both the postictal period (15–75 min after a seizure) and the interictal period (absence of seizure for >24 h) as compared with neurologically normal control subjects. Linear regression analyses and analysis of covariance showed that the reductions in serum QUIN and L‐kynurenine were correlated to blood antiepileptic medication. L‐Tryptophan (L‐TRP) levels also tended to be lower in both CSF and serum of the seizure patients. CSF KYNA and serum 3‐hydroxykynurenine concentrations were not affected in seizure patients, whereas serum levels of KYNA were reduced. 3‐Hydroxykynurenine was not detected in the CSF of either control or seizure patients. The results do not support a role for a generalized reduction in KYNA concentrations or an increased ratio of QUIN:KYNA, or increases in CSF L‐kynurenine in initiation and maintenance of intractable CPS humans.

Original languageEnglish
Pages (from-to)251-257
Number of pages7
JournalEpilepsia
Volume35
Issue number2
DOIs
Publication statusPublished - 03-1994
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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