TY - JOUR
T1 - L-type amino acid transporter-1 and CD98 expression in bone and soft tissue tumors
AU - Koshi, Hiromi
AU - Sano, Takaaki
AU - Handa, Tadashi
AU - Yanagawa, Takashi
AU - Saitou, Kenichi
AU - Nagamori, Shushi
AU - Kanai, Yoshikatsu
AU - Takagishi, Kenji
AU - Oyama, Tetsunari
N1 - Publisher Copyright:
© 2015 Japanese Society of Pathology and Wiley Publishing Asia Pty Ltd.
PY - 2015/9/1
Y1 - 2015/9/1
N2 - L-type amino acid transporter-1 (LAT1) is expressed in many cancers. We examined LAT1 and CD98 expression immunohistochemically in surgically resected specimens of various bone and soft tissue tumors. Out of 226 cases, 79 (35%) were LAT1+ and 95 (42%) were CD98+. In bone tumors, LAT1 was highly expressed in osteoblastoma (89%), chondrosarcoma (50%), and osteosarcoma (60%); in soft tissue tumors, LAT1 was highly expressed in rhabdomyosarcoma (80%), synovial sarcoma (63%), Ewing's sarcoma (60%), epithelioid sarcoma (100%) and angiosarcoma (100%). In malignant soft tissue tumors, LAT1 expression was associated with higher histological grade. High CD98 expression was seen in many bone tumors of intermediate and high malignancy. Among soft tissue tumors, CD98 was expressed in tendon sheath giant cell tumor and malignant peripheral nerve sheath tumor (57%), Ewing's sarcoma (50%) and undifferentiated sarcoma (64%). Some of the malignant soft tissue tumors expressed both LAT1 and CD98. This study showed that LAT1 and CD98 was expressed in many malignant and intermediate bone tumors, and some malignant soft tissue tumors.
AB - L-type amino acid transporter-1 (LAT1) is expressed in many cancers. We examined LAT1 and CD98 expression immunohistochemically in surgically resected specimens of various bone and soft tissue tumors. Out of 226 cases, 79 (35%) were LAT1+ and 95 (42%) were CD98+. In bone tumors, LAT1 was highly expressed in osteoblastoma (89%), chondrosarcoma (50%), and osteosarcoma (60%); in soft tissue tumors, LAT1 was highly expressed in rhabdomyosarcoma (80%), synovial sarcoma (63%), Ewing's sarcoma (60%), epithelioid sarcoma (100%) and angiosarcoma (100%). In malignant soft tissue tumors, LAT1 expression was associated with higher histological grade. High CD98 expression was seen in many bone tumors of intermediate and high malignancy. Among soft tissue tumors, CD98 was expressed in tendon sheath giant cell tumor and malignant peripheral nerve sheath tumor (57%), Ewing's sarcoma (50%) and undifferentiated sarcoma (64%). Some of the malignant soft tissue tumors expressed both LAT1 and CD98. This study showed that LAT1 and CD98 was expressed in many malignant and intermediate bone tumors, and some malignant soft tissue tumors.
KW - Bone tumors
KW - CD98
KW - Immunohistochemistry
KW - L-type amino acid transporter-1
KW - Soft tissue tumors
UR - https://www.scopus.com/pages/publications/84940796063
UR - https://www.scopus.com/pages/publications/84940796063#tab=citedBy
U2 - 10.1111/pin.12323
DO - 10.1111/pin.12323
M3 - Article
C2 - 26134029
AN - SCOPUS:84940796063
SN - 1320-5463
VL - 65
SP - 460
EP - 467
JO - Pathology International
JF - Pathology International
IS - 9
ER -
