TY - JOUR
T1 - Laboratory and clinical study of balofloxacin, a new fluoloquinolone, in urinary tract infection
AU - Suzuki, Keizo
AU - Horiba, Masaki
AU - Ishikawa, Kiyohito
AU - Katoh, Shinobu
AU - Naide, Yorio
AU - Hoshinaga, Kiyotaka
AU - Yanaoka, Masanori
AU - Tanaka, Toshiyuki
AU - Okishio, Norihiko
PY - 1995
Y1 - 1995
N2 - Balofloxacin (BLFX), one of the newer quinolones, was investigated for its in vitro activity, diffusion into prostatic fluid (PF) and clinical efficacy in the treatment of urinary tract infection (UTI). The results obtained were as follows. 1. In vitro activity: Against 80 strains of Enterococcus faecalis isolated from UTI, the MIC of BLFX ranged from 0.20˜25 μg/ml, and the MIC50and MIC90 were 0.78 μg/ml and 12.5 ƒÊg/ml, respectively, roughly comparable to sparfloxacin. The drug appeared to be superior to other reference drugs such as norfloxacin, ofloxacin and ciprofloxacin. However, BLFX was less potent against 50 strains of Pseudomonas aeruginosa, for which the MIC50 and MIC90 were as much as 25 μg/ml and > 100 μg/ml.
AB - Balofloxacin (BLFX), one of the newer quinolones, was investigated for its in vitro activity, diffusion into prostatic fluid (PF) and clinical efficacy in the treatment of urinary tract infection (UTI). The results obtained were as follows. 1. In vitro activity: Against 80 strains of Enterococcus faecalis isolated from UTI, the MIC of BLFX ranged from 0.20˜25 μg/ml, and the MIC50and MIC90 were 0.78 μg/ml and 12.5 ƒÊg/ml, respectively, roughly comparable to sparfloxacin. The drug appeared to be superior to other reference drugs such as norfloxacin, ofloxacin and ciprofloxacin. However, BLFX was less potent against 50 strains of Pseudomonas aeruginosa, for which the MIC50 and MIC90 were as much as 25 μg/ml and > 100 μg/ml.
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U2 - 10.11250/chemotherapy1995.43.Supplement5_310
DO - 10.11250/chemotherapy1995.43.Supplement5_310
M3 - Article
AN - SCOPUS:0029583916
SN - 1340-7007
VL - 43
SP - 310
EP - 316
JO - Japanese Journal of Chemotherapy
JF - Japanese Journal of Chemotherapy
ER -