Lack of an association between serum level of transforming growth factor beta -1 and stomach cancer risk in the JACC study.

Hiroshi Yatsuya, Akiko Tamakoshi, Koji Tamakoshi, Yoshiharu Hoshiyama, Yoshihisa Fujino, Noritaka Tokui, Tetsuya Mizoue, Shogo Kikuchi, Kiyomi Sakata, Norihiko Hayakawa, Takaaki Kondo, Hideaki Toyoshima, Takesumi Yoshimura

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Alterations in the serum concentration of transforming growth factor beta-1 (TGFbeta1) have been observed in gastric cancer patients. No study, however, has ever examined the association between the serum TGFbeta1 level and stomach cancer prospectively. We conducted a prospective, nested case-control analysis among apparently healthy men and women who were followed for up to 8 years in the JACC Study to assess whether serum level of total TGFbeta1 is associated with a subsequent risk of stomach cancer. The concentration of serum TGFbeta1 in previously collected blood samples was analyzed by ELISA for 209 individuals in whom a diagnosis of stomach cancer was documented, and for 409 controls matched with them for gender, age and study area. Baseline blood levels of TGFbeta1 were not related to the risk of stomach cancer in either men or women, a finding unchanged even after adjustment for potential confounders. The multivariate-adjusted odds ratio of stomach cancer in men and women was 1.10 (95% CI, 0.82 to 1.48) and 1.09 (95% CI, 0.80 to 1.48), respectively, for each increase of 1 SD in the TGFbeta1 value. In conclusion, serum TGFbeta1 levels were not associated with increased risks of subsequent stomach cancer.gene A52C polymorphism related to the metabolism of long-chain fatty acids and oxidized LDL in the etiology of colorectal cancer.

Original languageEnglish
Pages (from-to)170-176
Number of pages7
JournalAsian Pacific journal of cancer prevention : APJCP
Volume6
Issue number2
Publication statusPublished - 01-01-2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

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