Lack of anti-GOR antibody among subjects with GB virus C/hepatitis G virus RNA

Tatsunori Nakano, Masashi Mizokami, Kun Cao, Seiji Noguchi, Michio Sata, Young Min Park, Boo Sung Kim, Tsendsuren Oyunsuren, Leila Beltrao Pereira, Ruslan Ruzibakiev, Vladimir Gurtsevitch, Masanori Hayami

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Abstract

Homologies were sought between the putative amino acid sequences of GB virus C/hepatitis G virus (GBV-C/HGV) and the GOR epitope or the liver/kidney microsome-1 (LKM-1) epitope, which share partial sequence identity with the hepatitis C virus (HCV) polyprotein. Anti-GOR antibody (anti-GOR) was assayed among 100 subjects with GBV-C/HGV RNA. Twenty-one and 25 subjects were coinfected with hepatitis B virus (HBV) or HCV, respectively. Homologies were found between the NS5 or E2 polyproteins of GBV-C/HGV and the GOR epitope or the LKM-1 epitope, respectively. These segments of GBV-C/HGV polyproteins sharing identity with the GOR or the LKM-1 epitope were well conserved among three genotypes of GBV-C/HGV. However, only 1 of 55 subjects (1.8%) with GBV-C/HGV RNA, but not with HBV or HCV, was positive for anti-GOR. The positivity for anti-GOR among the group with GBV-C/HGV RNA alone was significantly lower than that among the groups with HCV RNA (P < 0.01 and P < 0.05, respectively). Only 2 of 55 subjects (3.6%) with GBV-C/HGV RNA alone exhibited elevation of alanine aminotransferase. The incidence of liver dysfunction among the group with GBV-C/HGV RNA alone was significantly lower than the incidence among the groups with GBV-C/HGV RNA and hepatitis B surface antigen (HBsAg) or HCV RNA (P < 0.01 and P < 0.01, respectively). These data indicate that 1) there is no association between GBV-C/HGV infection and the presence of anti-GOR, and 2) GBV-C/HGV infection is not related to chronic liver dysfunction.

Original languageEnglish
Pages (from-to)129-133
Number of pages5
JournalJournal of Medical Virology
Volume55
Issue number2
DOIs
Publication statusPublished - 01-06-1998
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Virology
  • Infectious Diseases

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    Nakano, T., Mizokami, M., Cao, K., Noguchi, S., Sata, M., Park, Y. M., Kim, B. S., Oyunsuren, T., Pereira, L. B., Ruzibakiev, R., Gurtsevitch, V., & Hayami, M. (1998). Lack of anti-GOR antibody among subjects with GB virus C/hepatitis G virus RNA. Journal of Medical Virology, 55(2), 129-133. https://doi.org/10.1002/(SICI)1096-9071(199806)55:2<129::AID-JMV8>3.0.CO;2-4