Lack of association between prokineticin 2 gene and Japanese methamphetamine dependence

Taro Kishi, Tsuyoshi Kitajima, Tomoko Tsunoka, Takenori Okumura, Kunihiro Kawashima, Tomo Okochi, Yoshio Yamanouchi, Yoko Kinoshita, Hiroshi Ujike, Toshiya Inada, Mitsuhiko Yamada, Naohisa Uchimura, Ichiro Sora, Masaomi Iyo, Norio Ozaki, Nakao Iwata

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Disruption of circadian rhythms may be involved in the pathophysiology of psychiatric disorders, including drug addiction. Recently, we detected the significant association between prokineticin 2 receptor gene (PROKR2) and Japanese methamphetamine dependence patients. Also, prokineticin 2 (PK2) gene deficient mice showed reduced physiological and behavioral parameters, including circadian locomotor activity, circulating glucocorticoid, glucose levels and the expression of peripheral clock genes compared with WT mice. These evidences indicate that PK2 gene (PROK2) is a good candidate gene for the pathogenesis of methamphetamine dependence. To evaluate the association between PROK2 and methamphetamine dependence, we conducted a case-control study of Japanese samples (215 methamphetamine dependence and 232 controls) with four tagging SNPs selected by HapMap database. The age and sex of the control subjects did not differ from those of the methamphetamine dependence patients. Written informed consent was obtained from each subject. This study was approved by the ethics committees at Fujita Health University, Nagoya University Graduate School of Medicine and each participating member of the Institute of the Japanese Genetics Initiative for Drug Abuse (JGIDA). We did not detect an association between PROK2 and Japanese methamphetamine dependence patients in allele/genotype-wise analysis, or the haplotype analysis. Our findings suggest that PROK2 does not play a major role in the pathophysiology of methamphetamine dependence in the Japanese population.

Original languageEnglish
Pages (from-to)133-136
Number of pages4
JournalCurrent Neuropharmacology
Volume9
Issue number1
DOIs
Publication statusPublished - 30-03-2011

Fingerprint

Methamphetamine
Genes
Substance-Related Disorders
HapMap Project
Ethics Committees
Locomotion
Circadian Rhythm
Informed Consent
Haplotypes
Glucocorticoids
Single Nucleotide Polymorphism
Psychiatry
Case-Control Studies
Alleles
Genotype
Medicine
Databases
Glucose
Health
Population

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this

Kishi, Taro ; Kitajima, Tsuyoshi ; Tsunoka, Tomoko ; Okumura, Takenori ; Kawashima, Kunihiro ; Okochi, Tomo ; Yamanouchi, Yoshio ; Kinoshita, Yoko ; Ujike, Hiroshi ; Inada, Toshiya ; Yamada, Mitsuhiko ; Uchimura, Naohisa ; Sora, Ichiro ; Iyo, Masaomi ; Ozaki, Norio ; Iwata, Nakao. / Lack of association between prokineticin 2 gene and Japanese methamphetamine dependence. In: Current Neuropharmacology. 2011 ; Vol. 9, No. 1. pp. 133-136.
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abstract = "Disruption of circadian rhythms may be involved in the pathophysiology of psychiatric disorders, including drug addiction. Recently, we detected the significant association between prokineticin 2 receptor gene (PROKR2) and Japanese methamphetamine dependence patients. Also, prokineticin 2 (PK2) gene deficient mice showed reduced physiological and behavioral parameters, including circadian locomotor activity, circulating glucocorticoid, glucose levels and the expression of peripheral clock genes compared with WT mice. These evidences indicate that PK2 gene (PROK2) is a good candidate gene for the pathogenesis of methamphetamine dependence. To evaluate the association between PROK2 and methamphetamine dependence, we conducted a case-control study of Japanese samples (215 methamphetamine dependence and 232 controls) with four tagging SNPs selected by HapMap database. The age and sex of the control subjects did not differ from those of the methamphetamine dependence patients. Written informed consent was obtained from each subject. This study was approved by the ethics committees at Fujita Health University, Nagoya University Graduate School of Medicine and each participating member of the Institute of the Japanese Genetics Initiative for Drug Abuse (JGIDA). We did not detect an association between PROK2 and Japanese methamphetamine dependence patients in allele/genotype-wise analysis, or the haplotype analysis. Our findings suggest that PROK2 does not play a major role in the pathophysiology of methamphetamine dependence in the Japanese population.",
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Kishi, T, Kitajima, T, Tsunoka, T, Okumura, T, Kawashima, K, Okochi, T, Yamanouchi, Y, Kinoshita, Y, Ujike, H, Inada, T, Yamada, M, Uchimura, N, Sora, I, Iyo, M, Ozaki, N & Iwata, N 2011, 'Lack of association between prokineticin 2 gene and Japanese methamphetamine dependence', Current Neuropharmacology, vol. 9, no. 1, pp. 133-136. https://doi.org/10.2174/157015911795016994

Lack of association between prokineticin 2 gene and Japanese methamphetamine dependence. / Kishi, Taro; Kitajima, Tsuyoshi; Tsunoka, Tomoko; Okumura, Takenori; Kawashima, Kunihiro; Okochi, Tomo; Yamanouchi, Yoshio; Kinoshita, Yoko; Ujike, Hiroshi; Inada, Toshiya; Yamada, Mitsuhiko; Uchimura, Naohisa; Sora, Ichiro; Iyo, Masaomi; Ozaki, Norio; Iwata, Nakao.

In: Current Neuropharmacology, Vol. 9, No. 1, 30.03.2011, p. 133-136.

Research output: Contribution to journalArticle

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T1 - Lack of association between prokineticin 2 gene and Japanese methamphetamine dependence

AU - Kishi, Taro

AU - Kitajima, Tsuyoshi

AU - Tsunoka, Tomoko

AU - Okumura, Takenori

AU - Kawashima, Kunihiro

AU - Okochi, Tomo

AU - Yamanouchi, Yoshio

AU - Kinoshita, Yoko

AU - Ujike, Hiroshi

AU - Inada, Toshiya

AU - Yamada, Mitsuhiko

AU - Uchimura, Naohisa

AU - Sora, Ichiro

AU - Iyo, Masaomi

AU - Ozaki, Norio

AU - Iwata, Nakao

PY - 2011/3/30

Y1 - 2011/3/30

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