TY - JOUR
T1 - Lack of association between TTV viral load and aminotransferase levels in patients with hepatitis C or non-B-C
AU - Kato, H.
AU - Mizokami, M.
AU - Orito, E.
AU - Ohno, T.
AU - Hayashi, K.
AU - Nakano, T.
AU - Kato, T.
AU - Tanaka, Y.
AU - Sugauchi, F.
AU - Mukaide, M.
AU - Ueda, R.
N1 - Funding Information:
MM was supported in part by a grant from the Japanese Ministry of Education, Science, Sports and Culture (Grant-in-Aid for Scientific Research 11691222), a grant from the Japanese Ministry of Health and Welfare, Health Science Research Grants (Non-A, Non-B Hepatitis Research Grants), from the Japanese International Corporation Agency, and by the Viral Hepatitis Research Foundation of Japan.
PY - 2000
Y1 - 2000
N2 - TT virus (TTV) is a newly identified un-enveloped single-stranded DNA virus. Although TTV was initially thought to be a new hepatitis virus, it is still unclear whether it causes hepatitis. To clarify the natural history and pathogenesis of TTV infection, serial serum samples from patients with chronic hepatitis were analysed. TTV DNA was quantified by real-time detection polymerase chain reaction assay (RTD-PCR), which was adapted for TTV. Five patients with chronic hepatitis, 4 with hepatitis C and 1 with non-B-C, were studied. The study period ranged from 9 to 50 months. In 3 patients there were frequent increases in TTV DNA titres, but no concomitant elevation of the aminotransferase (ALT) levels. In 2 patients who were treated with interferon, the changes in TTV titres were not synchronized with those of the ALT levels. Thus, in cases of chronic hepatitis, no correlation was observed between the serum TTV DNA titres and the ALT levels.
AB - TT virus (TTV) is a newly identified un-enveloped single-stranded DNA virus. Although TTV was initially thought to be a new hepatitis virus, it is still unclear whether it causes hepatitis. To clarify the natural history and pathogenesis of TTV infection, serial serum samples from patients with chronic hepatitis were analysed. TTV DNA was quantified by real-time detection polymerase chain reaction assay (RTD-PCR), which was adapted for TTV. Five patients with chronic hepatitis, 4 with hepatitis C and 1 with non-B-C, were studied. The study period ranged from 9 to 50 months. In 3 patients there were frequent increases in TTV DNA titres, but no concomitant elevation of the aminotransferase (ALT) levels. In 2 patients who were treated with interferon, the changes in TTV titres were not synchronized with those of the ALT levels. Thus, in cases of chronic hepatitis, no correlation was observed between the serum TTV DNA titres and the ALT levels.
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U2 - 10.1080/00365540050165884
DO - 10.1080/00365540050165884
M3 - Article
C2 - 10879595
AN - SCOPUS:0033894917
SN - 0036-5548
VL - 32
SP - 259
EP - 262
JO - Scandinavian Journal of Infectious Diseases
JF - Scandinavian Journal of Infectious Diseases
IS - 3
ER -
