Lack of association between TTV viral load and aminotransferase levels in patients with hepatitis C or non-B-C

H. Kato, M. Mizokami, E. Orito, T. Ohno, K. Hayashi, T. Nakano, T. Kato, Y. Tanaka, F. Sugauchi, M. Mukaide, R. Ueda

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6 Citations (Scopus)

Abstract

TT virus (TTV) is a newly identified un-enveloped single-stranded DNA virus. Although TTV was initially thought to be a new hepatitis virus, it is still unclear whether it causes hepatitis. To clarify the natural history and pathogenesis of TTV infection, serial serum samples from patients with chronic hepatitis were analysed. TTV DNA was quantified by real-time detection polymerase chain reaction assay (RTD-PCR), which was adapted for TTV. Five patients with chronic hepatitis, 4 with hepatitis C and 1 with non-B-C, were studied. The study period ranged from 9 to 50 months. In 3 patients there were frequent increases in TTV DNA titres, but no concomitant elevation of the aminotransferase (ALT) levels. In 2 patients who were treated with interferon, the changes in TTV titres were not synchronized with those of the ALT levels. Thus, in cases of chronic hepatitis, no correlation was observed between the serum TTV DNA titres and the ALT levels.

Original languageEnglish
Pages (from-to)259-262
Number of pages4
JournalScandinavian Journal of Infectious Diseases
Volume32
Issue number3
DOIs
Publication statusPublished - 2000

All Science Journal Classification (ASJC) codes

  • Immunology and Microbiology(all)
  • Microbiology (medical)
  • Infectious Diseases

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    Kato, H., Mizokami, M., Orito, E., Ohno, T., Hayashi, K., Nakano, T., Kato, T., Tanaka, Y., Sugauchi, F., Mukaide, M., & Ueda, R. (2000). Lack of association between TTV viral load and aminotransferase levels in patients with hepatitis C or non-B-C. Scandinavian Journal of Infectious Diseases, 32(3), 259-262. https://doi.org/10.1080/00365540050165884