TY - JOUR
T1 - Lack of association of EGR2 variants with bipolar disorder in Japanese population
AU - Balan, Shabeesh
AU - Yamada, Kazuo
AU - Iwayama, Yoshimi
AU - Toyota, Tomoko
AU - Ohnishi, Tetsuo
AU - Maekawa, Motoko
AU - Toyoshima, Manabu
AU - Iwata, Yasuhide
AU - Suzuki, Katsuaki
AU - Kikuchi, Mitsuru
AU - Ujike, Hiroshi
AU - Inada, Toshiya
AU - Kunugi, Hiroshi
AU - Ozaki, Norio
AU - Iwata, Nakao
AU - Nanko, Shinichiro
AU - Kato, Tadafumi
AU - Yoshikawa, Takeo
N1 - Funding Information:
This study was supported by RIKEN Brain Science Institute Funds . In addition, a part of this study is the result of the Strategic Research Program for Brain Sciences by the Ministry of Education, Culture, Sports, Science and Technology of Japan .
PY - 2013/9/10
Y1 - 2013/9/10
N2 - The early growth response gene 2 (EGR2) has been recently reported to be associated with bipolar disorder in the Korean population. However replication studies in independent cohorts of same and different ethnicities are essential for establishing the credibility of a genotype-phenotype association. With this notion, in the present study we have performed a replication study of the reported association of SNPs in EGR2 in a case-control study comprising of 867 unrelated Japanese bipolar disorder patients and 895 age-, sex- and ethnicity-matched controls. Results showed no significant differences in allele and genotype frequencies of EGR2 SNPs between bipolar disorder patients and controls and also in a sex-stratified genetic analysis. The haplotype and meta-analyses also showed no significant association with bipolar disorder. In conclusion, this is the first replication study of the previously reported association of EGR2 with bipolar disorder in a larger sample set and the results showed that the EGR2 gene is unlikely to contribute to the susceptibility of bipolar disorder in a Japanese cohort.
AB - The early growth response gene 2 (EGR2) has been recently reported to be associated with bipolar disorder in the Korean population. However replication studies in independent cohorts of same and different ethnicities are essential for establishing the credibility of a genotype-phenotype association. With this notion, in the present study we have performed a replication study of the reported association of SNPs in EGR2 in a case-control study comprising of 867 unrelated Japanese bipolar disorder patients and 895 age-, sex- and ethnicity-matched controls. Results showed no significant differences in allele and genotype frequencies of EGR2 SNPs between bipolar disorder patients and controls and also in a sex-stratified genetic analysis. The haplotype and meta-analyses also showed no significant association with bipolar disorder. In conclusion, this is the first replication study of the previously reported association of EGR2 with bipolar disorder in a larger sample set and the results showed that the EGR2 gene is unlikely to contribute to the susceptibility of bipolar disorder in a Japanese cohort.
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U2 - 10.1016/j.gene.2013.05.055
DO - 10.1016/j.gene.2013.05.055
M3 - Article
C2 - 23747400
AN - SCOPUS:84880707853
SN - 0378-1119
VL - 526
SP - 246
EP - 250
JO - Gene
JF - Gene
IS - 2
ER -