Lack of association of ovariectomy-induced obesity with overeating and the reduction of physical activities

Eiji Nishio, Takanori Hayashi, Masashi Nakatani, Noriko Aida, Risa Suda, Takuma Fujii, Toru Wakatsuki, Shinichiro Honda, Nobuhiro Harada, Y. Shimono

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Obesity commonly occurs in postmenopausal women, increasing the risk of various diseases. Estrogen can prevent obesity by activating lipid metabolism and suppressing depressive behavior. However, the reasons for obesity in postmenopausal women are not clearly elucidated. To mimic the effect of estrogen decline in postmenopausal women, we analyzed the behavior and the lipid metabolism-related genes, PPARγ and CD36 in ovariectomized (OVX) mice. The OVX mice showed increased visceral fat mass and PPARγ and CD36 expression in the visceral fat. In contrast, they were not significantly affected in terms of physical activity and food intake. Further, subcutaneous supplementation of estrogen effectively suppressed the increase in subcutaneous and visceral fat mass in OVX mice. We conclude that obesity in postmenopausal women is unlikely to be caused by overeating and reduction in physical activity, and subcutaneous supplementation of estrogen is an effective strategy to prevent obesity in postmenopausal women.

Original languageEnglish
Article number100671
JournalBiochemistry and Biophysics Reports
Volume20
DOIs
Publication statusPublished - 12-2019

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry

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