Lack of association of ovariectomy-induced obesity with overeating and the reduction of physical activities

Eiji Nishio, Takanori Hayashi, Masashi Nakatani, Noriko Aida, Risa Suda, Takuma Fujii, Toru Wakatsuki, Shinichiro Honda, Nobuhiro Harada, Y. Shimono

Research output: Contribution to journalArticle

Abstract

Obesity commonly occurs in postmenopausal women, increasing the risk of various diseases. Estrogen can prevent obesity by activating lipid metabolism and suppressing depressive behavior. However, the reasons for obesity in postmenopausal women are not clearly elucidated. To mimic the effect of estrogen decline in postmenopausal women, we analyzed the behavior and the lipid metabolism-related genes, PPARγ and CD36 in ovariectomized (OVX) mice. The OVX mice showed increased visceral fat mass and PPARγ and CD36 expression in the visceral fat. In contrast, they were not significantly affected in terms of physical activity and food intake. Further, subcutaneous supplementation of estrogen effectively suppressed the increase in subcutaneous and visceral fat mass in OVX mice. We conclude that obesity in postmenopausal women is unlikely to be caused by overeating and reduction in physical activity, and subcutaneous supplementation of estrogen is an effective strategy to prevent obesity in postmenopausal women.

Original languageEnglish
Article number100671
JournalBiochemistry and Biophysics Reports
Volume20
DOIs
Publication statusPublished - 12-2019

Fingerprint

Hyperphagia
Ovariectomy
Estrogens
Obesity
Association reactions
Exercise
Intra-Abdominal Fat
Peroxisome Proliferator-Activated Receptors
Fats
Lipid Metabolism
Subcutaneous Fat
Genes
Eating

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry

Cite this

Nishio, Eiji ; Hayashi, Takanori ; Nakatani, Masashi ; Aida, Noriko ; Suda, Risa ; Fujii, Takuma ; Wakatsuki, Toru ; Honda, Shinichiro ; Harada, Nobuhiro ; Shimono, Y. / Lack of association of ovariectomy-induced obesity with overeating and the reduction of physical activities. In: Biochemistry and Biophysics Reports. 2019 ; Vol. 20.
@article{819858a3eac1460b98c6b4a04edb280b,
title = "Lack of association of ovariectomy-induced obesity with overeating and the reduction of physical activities",
abstract = "Obesity commonly occurs in postmenopausal women, increasing the risk of various diseases. Estrogen can prevent obesity by activating lipid metabolism and suppressing depressive behavior. However, the reasons for obesity in postmenopausal women are not clearly elucidated. To mimic the effect of estrogen decline in postmenopausal women, we analyzed the behavior and the lipid metabolism-related genes, PPARγ and CD36 in ovariectomized (OVX) mice. The OVX mice showed increased visceral fat mass and PPARγ and CD36 expression in the visceral fat. In contrast, they were not significantly affected in terms of physical activity and food intake. Further, subcutaneous supplementation of estrogen effectively suppressed the increase in subcutaneous and visceral fat mass in OVX mice. We conclude that obesity in postmenopausal women is unlikely to be caused by overeating and reduction in physical activity, and subcutaneous supplementation of estrogen is an effective strategy to prevent obesity in postmenopausal women.",
author = "Eiji Nishio and Takanori Hayashi and Masashi Nakatani and Noriko Aida and Risa Suda and Takuma Fujii and Toru Wakatsuki and Shinichiro Honda and Nobuhiro Harada and Y. Shimono",
year = "2019",
month = "12",
doi = "10.1016/j.bbrep.2019.100671",
language = "English",
volume = "20",
journal = "Biochemistry and Biophysics Reports",
issn = "2405-5808",
publisher = "Elsevier BV",

}

Lack of association of ovariectomy-induced obesity with overeating and the reduction of physical activities. / Nishio, Eiji; Hayashi, Takanori; Nakatani, Masashi; Aida, Noriko; Suda, Risa; Fujii, Takuma; Wakatsuki, Toru; Honda, Shinichiro; Harada, Nobuhiro; Shimono, Y.

In: Biochemistry and Biophysics Reports, Vol. 20, 100671, 12.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Lack of association of ovariectomy-induced obesity with overeating and the reduction of physical activities

AU - Nishio, Eiji

AU - Hayashi, Takanori

AU - Nakatani, Masashi

AU - Aida, Noriko

AU - Suda, Risa

AU - Fujii, Takuma

AU - Wakatsuki, Toru

AU - Honda, Shinichiro

AU - Harada, Nobuhiro

AU - Shimono, Y.

PY - 2019/12

Y1 - 2019/12

N2 - Obesity commonly occurs in postmenopausal women, increasing the risk of various diseases. Estrogen can prevent obesity by activating lipid metabolism and suppressing depressive behavior. However, the reasons for obesity in postmenopausal women are not clearly elucidated. To mimic the effect of estrogen decline in postmenopausal women, we analyzed the behavior and the lipid metabolism-related genes, PPARγ and CD36 in ovariectomized (OVX) mice. The OVX mice showed increased visceral fat mass and PPARγ and CD36 expression in the visceral fat. In contrast, they were not significantly affected in terms of physical activity and food intake. Further, subcutaneous supplementation of estrogen effectively suppressed the increase in subcutaneous and visceral fat mass in OVX mice. We conclude that obesity in postmenopausal women is unlikely to be caused by overeating and reduction in physical activity, and subcutaneous supplementation of estrogen is an effective strategy to prevent obesity in postmenopausal women.

AB - Obesity commonly occurs in postmenopausal women, increasing the risk of various diseases. Estrogen can prevent obesity by activating lipid metabolism and suppressing depressive behavior. However, the reasons for obesity in postmenopausal women are not clearly elucidated. To mimic the effect of estrogen decline in postmenopausal women, we analyzed the behavior and the lipid metabolism-related genes, PPARγ and CD36 in ovariectomized (OVX) mice. The OVX mice showed increased visceral fat mass and PPARγ and CD36 expression in the visceral fat. In contrast, they were not significantly affected in terms of physical activity and food intake. Further, subcutaneous supplementation of estrogen effectively suppressed the increase in subcutaneous and visceral fat mass in OVX mice. We conclude that obesity in postmenopausal women is unlikely to be caused by overeating and reduction in physical activity, and subcutaneous supplementation of estrogen is an effective strategy to prevent obesity in postmenopausal women.

UR - http://www.scopus.com/inward/record.url?scp=85070315205&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85070315205&partnerID=8YFLogxK

U2 - 10.1016/j.bbrep.2019.100671

DO - 10.1016/j.bbrep.2019.100671

M3 - Article

AN - SCOPUS:85070315205

VL - 20

JO - Biochemistry and Biophysics Reports

JF - Biochemistry and Biophysics Reports

SN - 2405-5808

M1 - 100671

ER -