TY - JOUR
T1 - Lack of association of ovariectomy-induced obesity with overeating and the reduction of physical activities
AU - Nishio, Eiji
AU - Hayashi, Takanori
AU - Nakatani, Masashi
AU - Aida, Noriko
AU - Suda, Risa
AU - Fujii, Takuma
AU - Wakatsuki, Toru
AU - Honda, Shinichiro
AU - Harada, Nobuhiro
AU - Shimono, Y.
N1 - Funding Information:
This work was supported in part by Takeda Science Foundation (grant no. 656 ), Grants-in-Aid for Research from Fujita Health University, Japan , Aichi Health Promotion Foundation, Japan and Grant-in-Aid for Young Scientists (B), 2017–2019 (No. 17K16172 ), Japan.
Publisher Copyright:
© 2019 The Authors
PY - 2019/12
Y1 - 2019/12
N2 - Obesity commonly occurs in postmenopausal women, increasing the risk of various diseases. Estrogen can prevent obesity by activating lipid metabolism and suppressing depressive behavior. However, the reasons for obesity in postmenopausal women are not clearly elucidated. To mimic the effect of estrogen decline in postmenopausal women, we analyzed the behavior and the lipid metabolism-related genes, PPARγ and CD36 in ovariectomized (OVX) mice. The OVX mice showed increased visceral fat mass and PPARγ and CD36 expression in the visceral fat. In contrast, they were not significantly affected in terms of physical activity and food intake. Further, subcutaneous supplementation of estrogen effectively suppressed the increase in subcutaneous and visceral fat mass in OVX mice. We conclude that obesity in postmenopausal women is unlikely to be caused by overeating and reduction in physical activity, and subcutaneous supplementation of estrogen is an effective strategy to prevent obesity in postmenopausal women.
AB - Obesity commonly occurs in postmenopausal women, increasing the risk of various diseases. Estrogen can prevent obesity by activating lipid metabolism and suppressing depressive behavior. However, the reasons for obesity in postmenopausal women are not clearly elucidated. To mimic the effect of estrogen decline in postmenopausal women, we analyzed the behavior and the lipid metabolism-related genes, PPARγ and CD36 in ovariectomized (OVX) mice. The OVX mice showed increased visceral fat mass and PPARγ and CD36 expression in the visceral fat. In contrast, they were not significantly affected in terms of physical activity and food intake. Further, subcutaneous supplementation of estrogen effectively suppressed the increase in subcutaneous and visceral fat mass in OVX mice. We conclude that obesity in postmenopausal women is unlikely to be caused by overeating and reduction in physical activity, and subcutaneous supplementation of estrogen is an effective strategy to prevent obesity in postmenopausal women.
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U2 - 10.1016/j.bbrep.2019.100671
DO - 10.1016/j.bbrep.2019.100671
M3 - Article
AN - SCOPUS:85070315205
SN - 2405-5808
VL - 20
JO - Biochemistry and Biophysics Reports
JF - Biochemistry and Biophysics Reports
M1 - 100671
ER -