Lack of association of polymorphisms of the lymphotoxin α gene with myocardial infarction in Japanese

Akira Yamada, Sahoko Ichihara, Yosuke Murase, Tomoko Kato, Hideo Izawa, Kohzo Nagata, Toyoaki Murohara, Yoshiji Yamada, Mitsuhiro Yokota

Research output: Contribution to journalArticle

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Abstract

Vascular inflammation plays an important role in the development of myocardial infarction (MI). Lymphotoxin α (LTA) is a cytokine with multiple functions in regulation of the immune system and inflammatory reactions. The aim of this study was to examine whether polymorphisms of the LTA gene are associated with the risk of MI in Japanese men and women. A case-control association study was performed for the 252A→G and 804C→A polymorphisms of the LTA gene and the prevalence of MI. The study population comprised 3,689 unrelated Japanese individuals (2,486 men, 1,203 women), including 1891 patients with MI (1,493 men, 398 women) and 1798 control subjects (993 men, 805 women). Among the control subjects 257 individuals (108 men, 149 women) who had none of the conventional risk factors for coronary artery disease (CAD) were defined as low-risk controls. Genotypes for the two polymorphisms were determined with a fluorescence-based allele-specific DNA primer assay system. Among all study subjects the 252A→G and 804C→A polymorphisms exhibited linkage disequilibrium. No association of either polymorphism with MI was detected in men or in women in comparisons with total control or low-risk control subjects. However, each of the two polymorphisms was associated with the prevalence of type 2 diabetes mellitus both in men with MI and in those without MI in a recessive genetic model. No association was detected between the polymorphisms and other conventional risk factors for CAD. The LTA gene thus does not appear to be a susceptibility locus for MI in Japanese men or women, although it might affect susceptibility to type 2 diabetes in Japanese men.

Original languageEnglish
Pages (from-to)477-483
Number of pages7
JournalJournal of Molecular Medicine
Volume82
Issue number7
Publication statusPublished - 01-07-2004
Externally publishedYes

Fingerprint

Lymphotoxin-alpha
Myocardial Infarction
Genes
Type 2 Diabetes Mellitus
Coronary Artery Disease
DNA Primers
Genetic Models
Linkage Disequilibrium
Blood Vessels
Case-Control Studies
Immune System
Fluorescence
Alleles
Genotype
Cytokines
Inflammation

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery
  • Genetics(clinical)

Cite this

Yamada, A., Ichihara, S., Murase, Y., Kato, T., Izawa, H., Nagata, K., ... Yokota, M. (2004). Lack of association of polymorphisms of the lymphotoxin α gene with myocardial infarction in Japanese. Journal of Molecular Medicine, 82(7), 477-483.
Yamada, Akira ; Ichihara, Sahoko ; Murase, Yosuke ; Kato, Tomoko ; Izawa, Hideo ; Nagata, Kohzo ; Murohara, Toyoaki ; Yamada, Yoshiji ; Yokota, Mitsuhiro. / Lack of association of polymorphisms of the lymphotoxin α gene with myocardial infarction in Japanese. In: Journal of Molecular Medicine. 2004 ; Vol. 82, No. 7. pp. 477-483.
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abstract = "Vascular inflammation plays an important role in the development of myocardial infarction (MI). Lymphotoxin α (LTA) is a cytokine with multiple functions in regulation of the immune system and inflammatory reactions. The aim of this study was to examine whether polymorphisms of the LTA gene are associated with the risk of MI in Japanese men and women. A case-control association study was performed for the 252A→G and 804C→A polymorphisms of the LTA gene and the prevalence of MI. The study population comprised 3,689 unrelated Japanese individuals (2,486 men, 1,203 women), including 1891 patients with MI (1,493 men, 398 women) and 1798 control subjects (993 men, 805 women). Among the control subjects 257 individuals (108 men, 149 women) who had none of the conventional risk factors for coronary artery disease (CAD) were defined as low-risk controls. Genotypes for the two polymorphisms were determined with a fluorescence-based allele-specific DNA primer assay system. Among all study subjects the 252A→G and 804C→A polymorphisms exhibited linkage disequilibrium. No association of either polymorphism with MI was detected in men or in women in comparisons with total control or low-risk control subjects. However, each of the two polymorphisms was associated with the prevalence of type 2 diabetes mellitus both in men with MI and in those without MI in a recessive genetic model. No association was detected between the polymorphisms and other conventional risk factors for CAD. The LTA gene thus does not appear to be a susceptibility locus for MI in Japanese men or women, although it might affect susceptibility to type 2 diabetes in Japanese men.",
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Yamada, A, Ichihara, S, Murase, Y, Kato, T, Izawa, H, Nagata, K, Murohara, T, Yamada, Y & Yokota, M 2004, 'Lack of association of polymorphisms of the lymphotoxin α gene with myocardial infarction in Japanese', Journal of Molecular Medicine, vol. 82, no. 7, pp. 477-483.

Lack of association of polymorphisms of the lymphotoxin α gene with myocardial infarction in Japanese. / Yamada, Akira; Ichihara, Sahoko; Murase, Yosuke; Kato, Tomoko; Izawa, Hideo; Nagata, Kohzo; Murohara, Toyoaki; Yamada, Yoshiji; Yokota, Mitsuhiro.

In: Journal of Molecular Medicine, Vol. 82, No. 7, 01.07.2004, p. 477-483.

Research output: Contribution to journalArticle

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AU - Yamada, Akira

AU - Ichihara, Sahoko

AU - Murase, Yosuke

AU - Kato, Tomoko

AU - Izawa, Hideo

AU - Nagata, Kohzo

AU - Murohara, Toyoaki

AU - Yamada, Yoshiji

AU - Yokota, Mitsuhiro

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N2 - Vascular inflammation plays an important role in the development of myocardial infarction (MI). Lymphotoxin α (LTA) is a cytokine with multiple functions in regulation of the immune system and inflammatory reactions. The aim of this study was to examine whether polymorphisms of the LTA gene are associated with the risk of MI in Japanese men and women. A case-control association study was performed for the 252A→G and 804C→A polymorphisms of the LTA gene and the prevalence of MI. The study population comprised 3,689 unrelated Japanese individuals (2,486 men, 1,203 women), including 1891 patients with MI (1,493 men, 398 women) and 1798 control subjects (993 men, 805 women). Among the control subjects 257 individuals (108 men, 149 women) who had none of the conventional risk factors for coronary artery disease (CAD) were defined as low-risk controls. Genotypes for the two polymorphisms were determined with a fluorescence-based allele-specific DNA primer assay system. Among all study subjects the 252A→G and 804C→A polymorphisms exhibited linkage disequilibrium. No association of either polymorphism with MI was detected in men or in women in comparisons with total control or low-risk control subjects. However, each of the two polymorphisms was associated with the prevalence of type 2 diabetes mellitus both in men with MI and in those without MI in a recessive genetic model. No association was detected between the polymorphisms and other conventional risk factors for CAD. The LTA gene thus does not appear to be a susceptibility locus for MI in Japanese men or women, although it might affect susceptibility to type 2 diabetes in Japanese men.

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