Lack of initiation activity in rat liver of low doses of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline

Shoji Fukushima; Hideki Wanibuchi; Keiichirou Morimura; Min Wei; Dai Nakae; Yoichi Konishi; Hiroyuki Tsuda; Nobuo Takasuka; Katsumi Imaida; Tomoyuki Shirai; Masae Tatematsu; Tetsuya Tsukamoto; Masao Hirose; Fumio Furukawa

doi:10.1016/S0304-3835(02)00631-6

Lack of initiation activity in rat liver of low doses of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline

Shoji Fukushima, Hideki Wanibuchi, Keiichirou Morimura, Min Wei, Dai Nakae, Yoichi Konishi, Hiroyuki Tsuda, Nobuo Takasuka, Katsumi Imaida, Tomoyuki Shirai, Masae Tatematsu, Tetsuya Tsukamoto, Masao Hirose, Fumio Furukawa

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

It has been generally accepted that genotoxic carcinogens have no threshold in exerting their potential for cancer induction. However, the non-threshold theory can be challenged for cancer risk assessment in humans. Here we examined low dose carcinogenicity of a food-derived, genotoxic hepatocarcinogen, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), using an in vivo medium-term bioassay to detect initiating activity for rat hepatocarcinogenesis. With MeIQx initiation at various doses followed by administration of phenobarbital, a well known hepatopromoter, no induction of glutathione S-transferase placental form-positive foci, assessed as preneoplastic lesions, was noted at doses of 0.001-1 ppm. The results imply a no-observed effect level for hepatocarcinogenicity with this genotoxic agent.

Original language	English
Pages (from-to)	35-40
Number of pages	6
Journal	Cancer Letters
Volume	191
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3835(02)00631-6
Publication status	Published - 28-02-2003
Externally published	Yes

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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Fukushima, S., Wanibuchi, H., Morimura, K., Wei, M., Nakae, D., Konishi, Y., Tsuda, H., Takasuka, N., Imaida, K., Shirai, T., Tatematsu, M., Tsukamoto, T., Hirose, M., & Furukawa, F. (2003). Lack of initiation activity in rat liver of low doses of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline. Cancer Letters, 191(1), 35-40. https://doi.org/10.1016/S0304-3835(02)00631-6

Fukushima, Shoji ; Wanibuchi, Hideki ; Morimura, Keiichirou ; Wei, Min ; Nakae, Dai ; Konishi, Yoichi ; Tsuda, Hiroyuki ; Takasuka, Nobuo ; Imaida, Katsumi ; Shirai, Tomoyuki ; Tatematsu, Masae ; Tsukamoto, Tetsuya ; Hirose, Masao ; Furukawa, Fumio. / Lack of initiation activity in rat liver of low doses of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline. In: Cancer Letters. 2003 ; Vol. 191, No. 1. pp. 35-40.

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abstract = "It has been generally accepted that genotoxic carcinogens have no threshold in exerting their potential for cancer induction. However, the non-threshold theory can be challenged for cancer risk assessment in humans. Here we examined low dose carcinogenicity of a food-derived, genotoxic hepatocarcinogen, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), using an in vivo medium-term bioassay to detect initiating activity for rat hepatocarcinogenesis. With MeIQx initiation at various doses followed by administration of phenobarbital, a well known hepatopromoter, no induction of glutathione S-transferase placental form-positive foci, assessed as preneoplastic lesions, was noted at doses of 0.001-1 ppm. The results imply a no-observed effect level for hepatocarcinogenicity with this genotoxic agent.",

author = "Shoji Fukushima and Hideki Wanibuchi and Keiichirou Morimura and Min Wei and Dai Nakae and Yoichi Konishi and Hiroyuki Tsuda and Nobuo Takasuka and Katsumi Imaida and Tomoyuki Shirai and Masae Tatematsu and Tetsuya Tsukamoto and Masao Hirose and Fumio Furukawa",

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Lack of initiation activity in rat liver of low doses of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline. / Fukushima, Shoji; Wanibuchi, Hideki; Morimura, Keiichirou; Wei, Min; Nakae, Dai; Konishi, Yoichi; Tsuda, Hiroyuki; Takasuka, Nobuo; Imaida, Katsumi; Shirai, Tomoyuki; Tatematsu, Masae; Tsukamoto, Tetsuya; Hirose, Masao; Furukawa, Fumio.

In: Cancer Letters, Vol. 191, No. 1, 28.02.2003, p. 35-40.

Research output: Contribution to journal › Article › peer-review

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AU - Wei, Min

AU - Nakae, Dai

AU - Konishi, Yoichi

AU - Tsuda, Hiroyuki

AU - Takasuka, Nobuo

AU - Imaida, Katsumi

AU - Shirai, Tomoyuki

AU - Tatematsu, Masae

AU - Tsukamoto, Tetsuya

AU - Hirose, Masao

AU - Furukawa, Fumio

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