TY - JOUR
T1 - Lack of interleukin-1ß decreases the severity of atherosclerosis in apoE-deficient mice
AU - Kirii, Hirokazu
AU - Niwa, Tamikazu
AU - Yamada, Yasuhiro
AU - Wada, Hisayasu
AU - Saito, Kuniaki
AU - Iwakura, Yoichiro
AU - Asano, Masahide
AU - Moriwaki, Hisataka
AU - Seishima, Mitsuru
N1 - Copyright:
Copyright 2004 Elsevier Science B.V., Amsterdam. All rights reserved.
PY - 2003/4/1
Y1 - 2003/4/1
N2 - Objective - Atherosclerosis is considered to be a chronic inflammatory disease and many cytokines participate in the development of atherosclerosis, We focused on the role of interleukin-1β (IL-1β, one of the proinflammatory cytokines secreted by monocytes/macrophages, in the progression of atherosclerosis. Methods and Results - We generated mice lacking both apoE and IL-1β. The sizes of atherosclerotic lesions at the aortic sinus in apoE-/-/IL-1β-/- mice at 12 and 24 weeks of age showed a significant decrease of approximately 30% compared with apoE-/-/IL-1β+/+ mice, and the percentage of the atherosclerotic area to total area of apoE-/-/IL-1β-/- at 24 weeks of age also showed a significant decrease of about 30% compared with apoE-/-/IL-1β+/+. The mRNA levels of vascular cell adhesion molecule (VCAM)-1 and monocyte chemotactic protein-1 in the apoE-/-/ IL-1β-/- aorta were significantly reduced compared with the apoE-/-/IL-1β+/+. Furthermore, VCAM-1 was also reduced at the protein level in apoE-/-/IL-1β-/- aorta compared with apoE-/-/IL-1β+/+. Conclusions - The lack of IL-1β decreases the severity of atherosclerosis in apoE deficient mice, possibly through increased expressions of VCAM-1 and monocyte chemotactic protein-1 in the aorta.
AB - Objective - Atherosclerosis is considered to be a chronic inflammatory disease and many cytokines participate in the development of atherosclerosis, We focused on the role of interleukin-1β (IL-1β, one of the proinflammatory cytokines secreted by monocytes/macrophages, in the progression of atherosclerosis. Methods and Results - We generated mice lacking both apoE and IL-1β. The sizes of atherosclerotic lesions at the aortic sinus in apoE-/-/IL-1β-/- mice at 12 and 24 weeks of age showed a significant decrease of approximately 30% compared with apoE-/-/IL-1β+/+ mice, and the percentage of the atherosclerotic area to total area of apoE-/-/IL-1β-/- at 24 weeks of age also showed a significant decrease of about 30% compared with apoE-/-/IL-1β+/+. The mRNA levels of vascular cell adhesion molecule (VCAM)-1 and monocyte chemotactic protein-1 in the apoE-/-/ IL-1β-/- aorta were significantly reduced compared with the apoE-/-/IL-1β+/+. Furthermore, VCAM-1 was also reduced at the protein level in apoE-/-/IL-1β-/- aorta compared with apoE-/-/IL-1β+/+. Conclusions - The lack of IL-1β decreases the severity of atherosclerosis in apoE deficient mice, possibly through increased expressions of VCAM-1 and monocyte chemotactic protein-1 in the aorta.
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U2 - 10.1161/01.ATV.0000064374.15232.C3
DO - 10.1161/01.ATV.0000064374.15232.C3
M3 - Article
C2 - 12615675
AN - SCOPUS:0037388984
SN - 1079-5642
VL - 23
SP - 656
EP - 660
JO - Arteriosclerosis, thrombosis, and vascular biology
JF - Arteriosclerosis, thrombosis, and vascular biology
IS - 4
ER -