Lack of interleukin-1ß decreases the severity of atherosclerosis in apoE-deficient mice

Hirokazu Kirii; Tamikazu Niwa; Yasuhiro Yamada; Hisayasu Wada; Kuniaki Saito; Yoichiro Iwakura; Masahide Asano; Hisataka Moriwaki; Mitsuru Seishima

doi:10.1161/01.ATV.0000064374.15232.C3

Lack of interleukin-1ß decreases the severity of atherosclerosis in apoE-deficient mice

Hirokazu Kirii
, Tamikazu Niwa
, Yasuhiro Yamada
, Hisayasu Wada
, Kuniaki Saito
, Yoichiro Iwakura
, Masahide Asano
, Hisataka Moriwaki
, Mitsuru Seishima

Research output: Contribution to journal › Article › peer-review

696 Citations (Scopus)

Abstract

Objective - Atherosclerosis is considered to be a chronic inflammatory disease and many cytokines participate in the development of atherosclerosis, We focused on the role of interleukin-1β (IL-1β, one of the proinflammatory cytokines secreted by monocytes/macrophages, in the progression of atherosclerosis. Methods and Results - We generated mice lacking both apoE and IL-1β. The sizes of atherosclerotic lesions at the aortic sinus in apoE-/-/IL-1β-/- mice at 12 and 24 weeks of age showed a significant decrease of approximately 30% compared with apoE-/-/IL-1β^+/+ mice, and the percentage of the atherosclerotic area to total area of apoE-/-/IL-1β-/- at 24 weeks of age also showed a significant decrease of about 30% compared with apoE-/-/IL-1β^+/+. The mRNA levels of vascular cell adhesion molecule (VCAM)-1 and monocyte chemotactic protein-1 in the apoE-/-/ IL-1β-/- aorta were significantly reduced compared with the apoE-/-/IL-1β^+/+. Furthermore, VCAM-1 was also reduced at the protein level in apoE-/-/IL-1β-/- aorta compared with apoE-/-/IL-1β^+/+. Conclusions - The lack of IL-1β decreases the severity of atherosclerosis in apoE deficient mice, possibly through increased expressions of VCAM-1 and monocyte chemotactic protein-1 in the aorta.

Original language	English
Pages (from-to)	656-660
Number of pages	5
Journal	Arteriosclerosis, thrombosis, and vascular biology
Volume	23
Issue number	4
DOIs	https://doi.org/10.1161/01.ATV.0000064374.15232.C3
Publication status	Published - 01-04-2003
Externally published	Yes

All Science Journal Classification (ASJC) codes

Cardiology and Cardiovascular Medicine

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10.1161/01.ATV.0000064374.15232.C3

Cite this

@article{10f18bb0fc6444b99d12c30d715a9c0f,

title = "Lack of interleukin-1{\ss} decreases the severity of atherosclerosis in apoE-deficient mice",

abstract = "Objective - Atherosclerosis is considered to be a chronic inflammatory disease and many cytokines participate in the development of atherosclerosis, We focused on the role of interleukin-1β (IL-1β, one of the proinflammatory cytokines secreted by monocytes/macrophages, in the progression of atherosclerosis. Methods and Results - We generated mice lacking both apoE and IL-1β. The sizes of atherosclerotic lesions at the aortic sinus in apoE-/-/IL-1β-/- mice at 12 and 24 weeks of age showed a significant decrease of approximately 30\% compared with apoE-/-/IL-1β+/+ mice, and the percentage of the atherosclerotic area to total area of apoE-/-/IL-1β-/- at 24 weeks of age also showed a significant decrease of about 30\% compared with apoE-/-/IL-1β+/+. The mRNA levels of vascular cell adhesion molecule (VCAM)-1 and monocyte chemotactic protein-1 in the apoE-/-/ IL-1β-/- aorta were significantly reduced compared with the apoE-/-/IL-1β+/+. Furthermore, VCAM-1 was also reduced at the protein level in apoE-/-/IL-1β-/- aorta compared with apoE-/-/IL-1β+/+. Conclusions - The lack of IL-1β decreases the severity of atherosclerosis in apoE deficient mice, possibly through increased expressions of VCAM-1 and monocyte chemotactic protein-1 in the aorta.",

keywords = "Atherosclerosis, Interleukin-1β, Monocyte chemotactic protein-1, Vascular cell adhesion molecule-1",

author = "Hirokazu Kirii and Tamikazu Niwa and Yasuhiro Yamada and Hisayasu Wada and Kuniaki Saito and Yoichiro Iwakura and Masahide Asano and Hisataka Moriwaki and Mitsuru Seishima",

year = "2003",

month = apr,

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doi = "10.1161/01.ATV.0000064374.15232.C3",

language = "English",

volume = "23",

pages = "656--660",

journal = "Arteriosclerosis, thrombosis, and vascular biology",

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TY - JOUR

T1 - Lack of interleukin-1ß decreases the severity of atherosclerosis in apoE-deficient mice

AU - Kirii, Hirokazu

AU - Niwa, Tamikazu

AU - Yamada, Yasuhiro

AU - Wada, Hisayasu

AU - Saito, Kuniaki

AU - Iwakura, Yoichiro

AU - Asano, Masahide

AU - Moriwaki, Hisataka

AU - Seishima, Mitsuru

PY - 2003/4/1

Y1 - 2003/4/1

N2 - Objective - Atherosclerosis is considered to be a chronic inflammatory disease and many cytokines participate in the development of atherosclerosis, We focused on the role of interleukin-1β (IL-1β, one of the proinflammatory cytokines secreted by monocytes/macrophages, in the progression of atherosclerosis. Methods and Results - We generated mice lacking both apoE and IL-1β. The sizes of atherosclerotic lesions at the aortic sinus in apoE-/-/IL-1β-/- mice at 12 and 24 weeks of age showed a significant decrease of approximately 30% compared with apoE-/-/IL-1β+/+ mice, and the percentage of the atherosclerotic area to total area of apoE-/-/IL-1β-/- at 24 weeks of age also showed a significant decrease of about 30% compared with apoE-/-/IL-1β+/+. The mRNA levels of vascular cell adhesion molecule (VCAM)-1 and monocyte chemotactic protein-1 in the apoE-/-/ IL-1β-/- aorta were significantly reduced compared with the apoE-/-/IL-1β+/+. Furthermore, VCAM-1 was also reduced at the protein level in apoE-/-/IL-1β-/- aorta compared with apoE-/-/IL-1β+/+. Conclusions - The lack of IL-1β decreases the severity of atherosclerosis in apoE deficient mice, possibly through increased expressions of VCAM-1 and monocyte chemotactic protein-1 in the aorta.

AB - Objective - Atherosclerosis is considered to be a chronic inflammatory disease and many cytokines participate in the development of atherosclerosis, We focused on the role of interleukin-1β (IL-1β, one of the proinflammatory cytokines secreted by monocytes/macrophages, in the progression of atherosclerosis. Methods and Results - We generated mice lacking both apoE and IL-1β. The sizes of atherosclerotic lesions at the aortic sinus in apoE-/-/IL-1β-/- mice at 12 and 24 weeks of age showed a significant decrease of approximately 30% compared with apoE-/-/IL-1β+/+ mice, and the percentage of the atherosclerotic area to total area of apoE-/-/IL-1β-/- at 24 weeks of age also showed a significant decrease of about 30% compared with apoE-/-/IL-1β+/+. The mRNA levels of vascular cell adhesion molecule (VCAM)-1 and monocyte chemotactic protein-1 in the apoE-/-/ IL-1β-/- aorta were significantly reduced compared with the apoE-/-/IL-1β+/+. Furthermore, VCAM-1 was also reduced at the protein level in apoE-/-/IL-1β-/- aorta compared with apoE-/-/IL-1β+/+. Conclusions - The lack of IL-1β decreases the severity of atherosclerosis in apoE deficient mice, possibly through increased expressions of VCAM-1 and monocyte chemotactic protein-1 in the aorta.

KW - Atherosclerosis

KW - Interleukin-1β

KW - Monocyte chemotactic protein-1

KW - Vascular cell adhesion molecule-1

UR - https://www.scopus.com/pages/publications/0037388984

UR - https://www.scopus.com/pages/publications/0037388984#tab=citedBy

U2 - 10.1161/01.ATV.0000064374.15232.C3

DO - 10.1161/01.ATV.0000064374.15232.C3

M3 - Article

C2 - 12615675

AN - SCOPUS:0037388984

SN - 1079-5642

VL - 23

SP - 656

EP - 660

JO - Arteriosclerosis, thrombosis, and vascular biology

JF - Arteriosclerosis, thrombosis, and vascular biology

IS - 4

ER -

Lack of interleukin-1ß decreases the severity of atherosclerosis in apoE-deficient mice

Abstract

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