Lack of potential of low dose N-nitrosodimethylamine to induce preneoplastic lesions, glutathione S-transferase placental form-positive foci, in rat liver

Shoji Fukushima; Hideki Wanibuchi; Keiichirou Morimura; Dai Nakae; Hiroyuki Tsuda; Katsumi Imaida; Tomoyuki Shirai; Masae Tatematsu; Tetsuya Tsukamoto; Masao Hirose; Fumio Furukawa

doi:10.1016/j.canlet.2004.08.035

Lack of potential of low dose N-nitrosodimethylamine to induce preneoplastic lesions, glutathione S-transferase placental form-positive foci, in rat liver

Shoji Fukushima
, Hideki Wanibuchi
, Keiichirou Morimura
, Dai Nakae
, Hiroyuki Tsuda
, Katsumi Imaida
, Tomoyuki Shirai
, Masae Tatematsu
, Tetsuya Tsukamoto
, Masao Hirose
, Fumio Furukawa

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Induction of liver lesions in male F344 rats by the genotoxic and carcinogenic N-nitrosodimethylamine (NDMA) was studied at a wide range of dose levels, i.e. from 0.001 to 10 ppm, in drinking water for 16 weeks. Dose related and statistically significant increase of glutathione S-transferase placental form-positive foci, endpoint markers for hepatocarcinogenesis in rats, at 1 and 10 ppm dose groups was obtained, but no increment in foci could be detected with the lower doses (0.001, 0.01, and 0.1 ppm). This finding of a no-observed effect level supports our hypothesis that a threshold, at least in practical terms, exists in carcinogenesis proposed on the basis of extensive wide range dose-dependence studies of other genotoxic carcinogens.

Original language	English
Pages (from-to)	11-15
Number of pages	5
Journal	Cancer Letters
Volume	222
Issue number	1
DOIs	https://doi.org/10.1016/j.canlet.2004.08.035
Publication status	Published - 10-05-2005
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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10.1016/j.canlet.2004.08.035

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Fukushima, S., Wanibuchi, H., Morimura, K., Nakae, D., Tsuda, H., Imaida, K., Shirai, T., Tatematsu, M., Tsukamoto, T., Hirose, M., & Furukawa, F. (2005). Lack of potential of low dose N-nitrosodimethylamine to induce preneoplastic lesions, glutathione S-transferase placental form-positive foci, in rat liver. Cancer Letters, 222(1), 11-15. https://doi.org/10.1016/j.canlet.2004.08.035

@article{9a4a0297635840a28eb0e70e8d019493,

title = "Lack of potential of low dose N-nitrosodimethylamine to induce preneoplastic lesions, glutathione S-transferase placental form-positive foci, in rat liver",

abstract = "Induction of liver lesions in male F344 rats by the genotoxic and carcinogenic N-nitrosodimethylamine (NDMA) was studied at a wide range of dose levels, i.e. from 0.001 to 10 ppm, in drinking water for 16 weeks. Dose related and statistically significant increase of glutathione S-transferase placental form-positive foci, endpoint markers for hepatocarcinogenesis in rats, at 1 and 10 ppm dose groups was obtained, but no increment in foci could be detected with the lower doses (0.001, 0.01, and 0.1 ppm). This finding of a no-observed effect level supports our hypothesis that a threshold, at least in practical terms, exists in carcinogenesis proposed on the basis of extensive wide range dose-dependence studies of other genotoxic carcinogens.",

author = "Shoji Fukushima and Hideki Wanibuchi and Keiichirou Morimura and Dai Nakae and Hiroyuki Tsuda and Katsumi Imaida and Tomoyuki Shirai and Masae Tatematsu and Tetsuya Tsukamoto and Masao Hirose and Fumio Furukawa",

note = "Funding Information: This research was supported by a grant from the Japan Science and Technology Corporation, included in the Project of Core Research for Evolutional Science and Technology (CREST), and a Grant-in-Aid for Specially Promoted Research from the Ministry of Education, Science, Sports, Culture and Technology of Japan. The authors would also like to acknowledge the encouragement of Dr N. Ito (Emeritus Prof., Nagoya City University Medical School, Nagoya, Japan) and Dr T. Kitagawa (Director, Cancer Institute, Tokyo, Japan).",

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doi = "10.1016/j.canlet.2004.08.035",

language = "English",

volume = "222",

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Fukushima, S, Wanibuchi, H, Morimura, K, Nakae, D, Tsuda, H, Imaida, K, Shirai, T, Tatematsu, M, Tsukamoto, T, Hirose, M & Furukawa, F 2005, 'Lack of potential of low dose N-nitrosodimethylamine to induce preneoplastic lesions, glutathione S-transferase placental form-positive foci, in rat liver', Cancer Letters, vol. 222, no. 1, pp. 11-15. https://doi.org/10.1016/j.canlet.2004.08.035

TY - JOUR

T1 - Lack of potential of low dose N-nitrosodimethylamine to induce preneoplastic lesions, glutathione S-transferase placental form-positive foci, in rat liver

AU - Fukushima, Shoji

AU - Wanibuchi, Hideki

AU - Morimura, Keiichirou

AU - Nakae, Dai

AU - Tsuda, Hiroyuki

AU - Imaida, Katsumi

AU - Shirai, Tomoyuki

AU - Tatematsu, Masae

AU - Tsukamoto, Tetsuya

AU - Hirose, Masao

AU - Furukawa, Fumio

N1 - Funding Information: This research was supported by a grant from the Japan Science and Technology Corporation, included in the Project of Core Research for Evolutional Science and Technology (CREST), and a Grant-in-Aid for Specially Promoted Research from the Ministry of Education, Science, Sports, Culture and Technology of Japan. The authors would also like to acknowledge the encouragement of Dr N. Ito (Emeritus Prof., Nagoya City University Medical School, Nagoya, Japan) and Dr T. Kitagawa (Director, Cancer Institute, Tokyo, Japan).

PY - 2005/5/10

Y1 - 2005/5/10

N2 - Induction of liver lesions in male F344 rats by the genotoxic and carcinogenic N-nitrosodimethylamine (NDMA) was studied at a wide range of dose levels, i.e. from 0.001 to 10 ppm, in drinking water for 16 weeks. Dose related and statistically significant increase of glutathione S-transferase placental form-positive foci, endpoint markers for hepatocarcinogenesis in rats, at 1 and 10 ppm dose groups was obtained, but no increment in foci could be detected with the lower doses (0.001, 0.01, and 0.1 ppm). This finding of a no-observed effect level supports our hypothesis that a threshold, at least in practical terms, exists in carcinogenesis proposed on the basis of extensive wide range dose-dependence studies of other genotoxic carcinogens.

AB - Induction of liver lesions in male F344 rats by the genotoxic and carcinogenic N-nitrosodimethylamine (NDMA) was studied at a wide range of dose levels, i.e. from 0.001 to 10 ppm, in drinking water for 16 weeks. Dose related and statistically significant increase of glutathione S-transferase placental form-positive foci, endpoint markers for hepatocarcinogenesis in rats, at 1 and 10 ppm dose groups was obtained, but no increment in foci could be detected with the lower doses (0.001, 0.01, and 0.1 ppm). This finding of a no-observed effect level supports our hypothesis that a threshold, at least in practical terms, exists in carcinogenesis proposed on the basis of extensive wide range dose-dependence studies of other genotoxic carcinogens.

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DO - 10.1016/j.canlet.2004.08.035

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AN - SCOPUS:20244387173

SN - 0304-3835

VL - 222

SP - 11

EP - 15

JO - Cancer Letters

JF - Cancer Letters

IS - 1

ER -

Lack of potential of low dose N-nitrosodimethylamine to induce preneoplastic lesions, glutathione S-transferase placental form-positive foci, in rat liver

Abstract

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