Lactate dehydrogenase is a prognostic indicator for prostate cancer patients with bone metastasis

Katsuya Naruse, Yoshiaki Yamada, Shigeyuki Aoki, Tomohiro Taki, Kogenta Nakamura, Motoi Tobiume, Kenji Zennami, Remi Katsuda, Shotoku Sai, Yoshitaka Nishmo, Yasusuke Inoue, Hiroshi Noguchi, Nobuaki Honda

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

We analyzed clinical data to identify prognostic indicators in prostate cancer patients with bone metastasis. The subjects were 60 patients with bone metastasis out of 165 patients diagnosed with prostate cancer at our clinic over 6 years from January 1998 to December 2003. The age at the initial diagnosis was 61 to 91 (mean: 73.7 ± 7.5) years old. The following items were considered to be possible prognostic indicators : T (type) classification, N (node) classification, Gleason score, prostate specific antigen (PSA) value before therapy, disease grade, alkaline phosphatase (ALP), lactate dehydrogenase (LDH), serum calcium (Ca), hemoglobin (Hgb), and platelet count (Pit). The 5-year overall survival rate was 45.7% in the 60 patients. Univariate analysis showed statistically significant differences in N (1), Gleason score 7 + 8/Gleason score 9 +10, and LDH level (p = 0.0053, 0.0261, and 0.0049, respectively). Multivariate Cox proportional hazard analysis of these three items showed a statistically significant difference in LDH level and Gleason score 9 +10 (p = 0.0167 and 0.0371). LDH was suggested to be an excellent prognostic indicator, because of its objectivity and convenience of measurement, in prostate cancer patients with bone metastasis.

Original languageEnglish
Pages (from-to)287-292
Number of pages6
JournalActa Urologica Japonica
Volume53
Issue number5
Publication statusPublished - 05-2007

All Science Journal Classification (ASJC) codes

  • Urology

Fingerprint Dive into the research topics of 'Lactate dehydrogenase is a prognostic indicator for prostate cancer patients with bone metastasis'. Together they form a unique fingerprint.

  • Cite this

    Naruse, K., Yamada, Y., Aoki, S., Taki, T., Nakamura, K., Tobiume, M., Zennami, K., Katsuda, R., Sai, S., Nishmo, Y., Inoue, Y., Noguchi, H., & Honda, N. (2007). Lactate dehydrogenase is a prognostic indicator for prostate cancer patients with bone metastasis. Acta Urologica Japonica, 53(5), 287-292.