TY - JOUR
T1 - Lactate dehydrogenase is a prognostic indicator for prostate cancer patients with bone metastasis
AU - Naruse, Katsuya
AU - Yamada, Yoshiaki
AU - Aoki, Shigeyuki
AU - Taki, Tomohiro
AU - Nakamura, Kogenta
AU - Tobiume, Motoi
AU - Zennami, Kenji
AU - Katsuda, Remi
AU - Sai, Shotoku
AU - Nishmo, Yoshitaka
AU - Inoue, Yasusuke
AU - Noguchi, Hiroshi
AU - Honda, Nobuaki
PY - 2007/5
Y1 - 2007/5
N2 - We analyzed clinical data to identify prognostic indicators in prostate cancer patients with bone metastasis. The subjects were 60 patients with bone metastasis out of 165 patients diagnosed with prostate cancer at our clinic over 6 years from January 1998 to December 2003. The age at the initial diagnosis was 61 to 91 (mean: 73.7 ± 7.5) years old. The following items were considered to be possible prognostic indicators : T (type) classification, N (node) classification, Gleason score, prostate specific antigen (PSA) value before therapy, disease grade, alkaline phosphatase (ALP), lactate dehydrogenase (LDH), serum calcium (Ca), hemoglobin (Hgb), and platelet count (Pit). The 5-year overall survival rate was 45.7% in the 60 patients. Univariate analysis showed statistically significant differences in N (1), Gleason score 7 + 8/Gleason score 9 +10, and LDH level (p = 0.0053, 0.0261, and 0.0049, respectively). Multivariate Cox proportional hazard analysis of these three items showed a statistically significant difference in LDH level and Gleason score 9 +10 (p = 0.0167 and 0.0371). LDH was suggested to be an excellent prognostic indicator, because of its objectivity and convenience of measurement, in prostate cancer patients with bone metastasis.
AB - We analyzed clinical data to identify prognostic indicators in prostate cancer patients with bone metastasis. The subjects were 60 patients with bone metastasis out of 165 patients diagnosed with prostate cancer at our clinic over 6 years from January 1998 to December 2003. The age at the initial diagnosis was 61 to 91 (mean: 73.7 ± 7.5) years old. The following items were considered to be possible prognostic indicators : T (type) classification, N (node) classification, Gleason score, prostate specific antigen (PSA) value before therapy, disease grade, alkaline phosphatase (ALP), lactate dehydrogenase (LDH), serum calcium (Ca), hemoglobin (Hgb), and platelet count (Pit). The 5-year overall survival rate was 45.7% in the 60 patients. Univariate analysis showed statistically significant differences in N (1), Gleason score 7 + 8/Gleason score 9 +10, and LDH level (p = 0.0053, 0.0261, and 0.0049, respectively). Multivariate Cox proportional hazard analysis of these three items showed a statistically significant difference in LDH level and Gleason score 9 +10 (p = 0.0167 and 0.0371). LDH was suggested to be an excellent prognostic indicator, because of its objectivity and convenience of measurement, in prostate cancer patients with bone metastasis.
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M3 - Article
C2 - 17561711
AN - SCOPUS:34250891436
SN - 0018-1994
VL - 53
SP - 287
EP - 292
JO - Acta Urologica Japonica
JF - Acta Urologica Japonica
IS - 5
ER -
