Langerhans cells in the lymph node: mirror section and immunoelectron microscopic studies

Mikihiro Shamoto, Masanori Shinzato, Satoru Hosokawa, Chiyuki Kaneko, Takashi Hakuno, Kazutaka Nomoto

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Cells immunostained with antibodies against both OKT-6 and S-100 protein were observed only in superficial and hilar lymph nodes draining tissues with predominantly squamous epithelia. In contrast, in mesenteric lymph nodes and the spleen, only S-100 protein-positive, but OKT-6-negative cells were found. We suspect that the S-100 and OKT-6-positive cells might be Langerhans cells (LC) and the S-100-positive, OKT-6-negative cells, interdigitating reticulum cells (IDC). We further postulate that the LC in superficial and hilar lymph nodes might migrate from squamous epithelia, with which contact is required for the formation of Birbeck granules.

Original languageEnglish
Pages (from-to)337-341
Number of pages5
JournalVirchows Archiv B Cell Pathology Including Molecular Pathology
Volume61
Issue number1
DOIs
Publication statusPublished - 01-12-1992

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

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