TY - JOUR
T1 - Langerhans cells in the lymph node
T2 - mirror section and immunoelectron microscopic studies
AU - Shamoto, Mikihiro
AU - Shinzato, Masanori
AU - Hosokawa, Satoru
AU - Kaneko, Chiyuki
AU - Hakuno, Takashi
AU - Nomoto, Kazutaka
PY - 1992/12
Y1 - 1992/12
N2 - Cells immunostained with antibodies against both OKT-6 and S-100 protein were observed only in superficial and hilar lymph nodes draining tissues with predominantly squamous epithelia. In contrast, in mesenteric lymph nodes and the spleen, only S-100 protein-positive, but OKT-6-negative cells were found. We suspect that the S-100 and OKT-6-positive cells might be Langerhans cells (LC) and the S-100-positive, OKT-6-negative cells, interdigitating reticulum cells (IDC). We further postulate that the LC in superficial and hilar lymph nodes might migrate from squamous epithelia, with which contact is required for the formation of Birbeck granules.
AB - Cells immunostained with antibodies against both OKT-6 and S-100 protein were observed only in superficial and hilar lymph nodes draining tissues with predominantly squamous epithelia. In contrast, in mesenteric lymph nodes and the spleen, only S-100 protein-positive, but OKT-6-negative cells were found. We suspect that the S-100 and OKT-6-positive cells might be Langerhans cells (LC) and the S-100-positive, OKT-6-negative cells, interdigitating reticulum cells (IDC). We further postulate that the LC in superficial and hilar lymph nodes might migrate from squamous epithelia, with which contact is required for the formation of Birbeck granules.
UR - http://www.scopus.com/inward/record.url?scp=0026569867&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026569867&partnerID=8YFLogxK
U2 - 10.1007/BF02890436
DO - 10.1007/BF02890436
M3 - Article
C2 - 1373548
AN - SCOPUS:0026569867
SN - 0042-6431
VL - 61
SP - 337
EP - 341
JO - Virchows Archiv B Cell Pathology Including Molecular Pathology
JF - Virchows Archiv B Cell Pathology Including Molecular Pathology
IS - 1
ER -