TY - JOUR
T1 - Language-related cerebral oscillatory changes are influenced equally by genetic and environmental factors
AU - Osaka Twin Research Group
AU - Araki, Toshihiko
AU - Hirata, Masayuki
AU - Yanagisawa, Takufumi
AU - Sugata, Hisato
AU - Onishi, Mai
AU - Watanabe, Yoshiyuki
AU - Ogata, Soshiro
AU - Honda, Chika
AU - Hayakawa, Kazuo
AU - Yorifuji, Shiro
AU - Iwatani, Yoshinori
AU - Sakai, Norio
AU - Kamide, Kei
AU - Kihara, Shinji
AU - Makimoto, Kiyoko
AU - Watanabe, Hiroko
AU - Hatazawa, Jun
AU - Takahashi, Masanori
AU - Watanabe, Mikio
AU - Honda, Chika
AU - Tomizawa, Rie
N1 - Funding Information:
We thank the twins for participating in this study. This study was supported by JSPS KAKENHI Grant Number 15K12701 , 26282165 , 15J03698 . Osaka University Center for Twin Research is supported as part of Management Expenses Grant from the Ministry of Education, Science, Sports, and Culture of Japan.
Publisher Copyright:
© 2016 Elsevier Inc.
PY - 2016/11/15
Y1 - 2016/11/15
N2 - Twin studies have suggested that there are genetic influences on inter-individual variation in terms of verbal abilities, and candidate genes have been identified by genome-wide association studies. However, the brain activities under genetic influence during linguistic processing remain unclear. In this study, we investigated neuromagnetic activities during a language task in a group of 28 monozygotic (MZ) and 12 dizygotic (DZ) adult twin pairs. We examined the spatio-temporal distribution of the event-related desynchronizations (ERDs) in the low gamma band (25–50 Hz) using beamformer analyses and time–frequency analyses. Heritability was evaluated by comparing the respective MZ and DZ correlations. The genetic and environmental contributions were then estimated by structural equation modeling (SEM). We found that the peaks of the low gamma ERDs were localized to the left frontal area. The power of low gamma ERDs in this area exhibited higher similarity between MZ twins than that between DZ twins. SEM estimated the genetic contribution as approximately 50%. In addition, these powers were negatively correlated with the behavioral verbal scores. These results improve our understanding of how genetic and environmental factors influence cerebral activities during linguistic processes.
AB - Twin studies have suggested that there are genetic influences on inter-individual variation in terms of verbal abilities, and candidate genes have been identified by genome-wide association studies. However, the brain activities under genetic influence during linguistic processing remain unclear. In this study, we investigated neuromagnetic activities during a language task in a group of 28 monozygotic (MZ) and 12 dizygotic (DZ) adult twin pairs. We examined the spatio-temporal distribution of the event-related desynchronizations (ERDs) in the low gamma band (25–50 Hz) using beamformer analyses and time–frequency analyses. Heritability was evaluated by comparing the respective MZ and DZ correlations. The genetic and environmental contributions were then estimated by structural equation modeling (SEM). We found that the peaks of the low gamma ERDs were localized to the left frontal area. The power of low gamma ERDs in this area exhibited higher similarity between MZ twins than that between DZ twins. SEM estimated the genetic contribution as approximately 50%. In addition, these powers were negatively correlated with the behavioral verbal scores. These results improve our understanding of how genetic and environmental factors influence cerebral activities during linguistic processes.
UR - http://www.scopus.com/inward/record.url?scp=84994056563&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84994056563&partnerID=8YFLogxK
U2 - 10.1016/j.neuroimage.2016.05.066
DO - 10.1016/j.neuroimage.2016.05.066
M3 - Article
C2 - 27241483
AN - SCOPUS:84994056563
VL - 142
SP - 241
EP - 247
JO - NeuroImage
JF - NeuroImage
SN - 1053-8119
ER -