Large-scale association analysis in Asians identifies new susceptibility loci for prostate cancer

Meilin Wang, Atsushi Takahashi, Fang Liu, Dingwei Ye, Qiang Ding, Chao Qin, Changjun Yin, Zhengdong Zhang, Koichi Matsuda, Michiaki Kubo, Rong Na, Xiaoling Lin, Haowen Jiang, Shancheng Ren, Jielin Sun, S. Lilly Zheng, Loic Le Marchand, William B. Isaacs, Zengnan Mo, Christopher A. Haiman & 3 others Yinghao Sun, Hidewaki Nakagawa, Jianfeng Xu

Research output: Contribution to journalArticle

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Abstract

Genome-wide association studies (GWAS) have identified 1/4100 genetic loci associated with prostate cancer risk. Less than a dozen of these loci were initially identified from GWAS in two Asian populations, likely because of smaller sample sizes of these individual GWAS in Asians. Here, we conduct a large-scale meta-analysis of two GWAS from the Japanese population (1,583 cases and 3,386 controls) and the Chinese population (1,417 cases and 1,008 controls), followed by replication in three independent sample sets. We identify two independent susceptibility loci for prostate cancer at 11p15.4 (rs12791447, P=3.59 × 10-8; PPFIBP2) and 14q23.2 (rs58262369, P=6.05 × 10-10; ESR2). The mRNA levels of PPFIBP2 and ESR2 are differentially expressed in prostate tumours and paired normal tissues. Our study adds two new loci to the limited number of prostate cancer risk-associated variants in Asians and provides important insight into potential biological mechanisms of prostate cancer.

Original languageEnglish
Article number8469
JournalNature Communications
Volume6
DOIs
Publication statusPublished - 07-10-2015

Fingerprint

genome
Genome-Wide Association Study
loci
Prostatic Neoplasms
Genes
cancer
magnetic permeability
Population
Genetic Loci
Sample Size
Meta-Analysis
Tumors
Prostate
tumors
Tissue
Messenger RNA
Neoplasms

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Wang, Meilin ; Takahashi, Atsushi ; Liu, Fang ; Ye, Dingwei ; Ding, Qiang ; Qin, Chao ; Yin, Changjun ; Zhang, Zhengdong ; Matsuda, Koichi ; Kubo, Michiaki ; Na, Rong ; Lin, Xiaoling ; Jiang, Haowen ; Ren, Shancheng ; Sun, Jielin ; Zheng, S. Lilly ; Marchand, Loic Le ; Isaacs, William B. ; Mo, Zengnan ; Haiman, Christopher A. ; Sun, Yinghao ; Nakagawa, Hidewaki ; Xu, Jianfeng. / Large-scale association analysis in Asians identifies new susceptibility loci for prostate cancer. In: Nature Communications. 2015 ; Vol. 6.
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title = "Large-scale association analysis in Asians identifies new susceptibility loci for prostate cancer",
abstract = "Genome-wide association studies (GWAS) have identified 1/4100 genetic loci associated with prostate cancer risk. Less than a dozen of these loci were initially identified from GWAS in two Asian populations, likely because of smaller sample sizes of these individual GWAS in Asians. Here, we conduct a large-scale meta-analysis of two GWAS from the Japanese population (1,583 cases and 3,386 controls) and the Chinese population (1,417 cases and 1,008 controls), followed by replication in three independent sample sets. We identify two independent susceptibility loci for prostate cancer at 11p15.4 (rs12791447, P=3.59 × 10-8; PPFIBP2) and 14q23.2 (rs58262369, P=6.05 × 10-10; ESR2). The mRNA levels of PPFIBP2 and ESR2 are differentially expressed in prostate tumours and paired normal tissues. Our study adds two new loci to the limited number of prostate cancer risk-associated variants in Asians and provides important insight into potential biological mechanisms of prostate cancer.",
author = "Meilin Wang and Atsushi Takahashi and Fang Liu and Dingwei Ye and Qiang Ding and Chao Qin and Changjun Yin and Zhengdong Zhang and Koichi Matsuda and Michiaki Kubo and Rong Na and Xiaoling Lin and Haowen Jiang and Shancheng Ren and Jielin Sun and Zheng, {S. Lilly} and Marchand, {Loic Le} and Isaacs, {William B.} and Zengnan Mo and Haiman, {Christopher A.} and Yinghao Sun and Hidewaki Nakagawa and Jianfeng Xu",
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Wang, M, Takahashi, A, Liu, F, Ye, D, Ding, Q, Qin, C, Yin, C, Zhang, Z, Matsuda, K, Kubo, M, Na, R, Lin, X, Jiang, H, Ren, S, Sun, J, Zheng, SL, Marchand, LL, Isaacs, WB, Mo, Z, Haiman, CA, Sun, Y, Nakagawa, H & Xu, J 2015, 'Large-scale association analysis in Asians identifies new susceptibility loci for prostate cancer', Nature Communications, vol. 6, 8469. https://doi.org/10.1038/ncomms9469

Large-scale association analysis in Asians identifies new susceptibility loci for prostate cancer. / Wang, Meilin; Takahashi, Atsushi; Liu, Fang; Ye, Dingwei; Ding, Qiang; Qin, Chao; Yin, Changjun; Zhang, Zhengdong; Matsuda, Koichi; Kubo, Michiaki; Na, Rong; Lin, Xiaoling; Jiang, Haowen; Ren, Shancheng; Sun, Jielin; Zheng, S. Lilly; Marchand, Loic Le; Isaacs, William B.; Mo, Zengnan; Haiman, Christopher A.; Sun, Yinghao; Nakagawa, Hidewaki; Xu, Jianfeng.

In: Nature Communications, Vol. 6, 8469, 07.10.2015.

Research output: Contribution to journalArticle

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T1 - Large-scale association analysis in Asians identifies new susceptibility loci for prostate cancer

AU - Wang, Meilin

AU - Takahashi, Atsushi

AU - Liu, Fang

AU - Ye, Dingwei

AU - Ding, Qiang

AU - Qin, Chao

AU - Yin, Changjun

AU - Zhang, Zhengdong

AU - Matsuda, Koichi

AU - Kubo, Michiaki

AU - Na, Rong

AU - Lin, Xiaoling

AU - Jiang, Haowen

AU - Ren, Shancheng

AU - Sun, Jielin

AU - Zheng, S. Lilly

AU - Marchand, Loic Le

AU - Isaacs, William B.

AU - Mo, Zengnan

AU - Haiman, Christopher A.

AU - Sun, Yinghao

AU - Nakagawa, Hidewaki

AU - Xu, Jianfeng

PY - 2015/10/7

Y1 - 2015/10/7

N2 - Genome-wide association studies (GWAS) have identified 1/4100 genetic loci associated with prostate cancer risk. Less than a dozen of these loci were initially identified from GWAS in two Asian populations, likely because of smaller sample sizes of these individual GWAS in Asians. Here, we conduct a large-scale meta-analysis of two GWAS from the Japanese population (1,583 cases and 3,386 controls) and the Chinese population (1,417 cases and 1,008 controls), followed by replication in three independent sample sets. We identify two independent susceptibility loci for prostate cancer at 11p15.4 (rs12791447, P=3.59 × 10-8; PPFIBP2) and 14q23.2 (rs58262369, P=6.05 × 10-10; ESR2). The mRNA levels of PPFIBP2 and ESR2 are differentially expressed in prostate tumours and paired normal tissues. Our study adds two new loci to the limited number of prostate cancer risk-associated variants in Asians and provides important insight into potential biological mechanisms of prostate cancer.

AB - Genome-wide association studies (GWAS) have identified 1/4100 genetic loci associated with prostate cancer risk. Less than a dozen of these loci were initially identified from GWAS in two Asian populations, likely because of smaller sample sizes of these individual GWAS in Asians. Here, we conduct a large-scale meta-analysis of two GWAS from the Japanese population (1,583 cases and 3,386 controls) and the Chinese population (1,417 cases and 1,008 controls), followed by replication in three independent sample sets. We identify two independent susceptibility loci for prostate cancer at 11p15.4 (rs12791447, P=3.59 × 10-8; PPFIBP2) and 14q23.2 (rs58262369, P=6.05 × 10-10; ESR2). The mRNA levels of PPFIBP2 and ESR2 are differentially expressed in prostate tumours and paired normal tissues. Our study adds two new loci to the limited number of prostate cancer risk-associated variants in Asians and provides important insight into potential biological mechanisms of prostate cancer.

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