TY - JOUR
T1 - Large-scale association analysis in Asians identifies new susceptibility loci for prostate cancer
AU - Wang, Meilin
AU - Takahashi, Atsushi
AU - Liu, Fang
AU - Ye, Dingwei
AU - Ding, Qiang
AU - Qin, Chao
AU - Yin, Changjun
AU - Zhang, Zhengdong
AU - Matsuda, Koichi
AU - Kubo, Michiaki
AU - Na, Rong
AU - Lin, Xiaoling
AU - Jiang, Haowen
AU - Ren, Shancheng
AU - Sun, Jielin
AU - Zheng, S. Lilly
AU - Marchand, Loic Le
AU - Isaacs, William B.
AU - Mo, Zengnan
AU - Haiman, Christopher A.
AU - Sun, Yinghao
AU - Nakagawa, Hidewaki
AU - Xu, Jianfeng
N1 - Funding Information:
This work was in part supported by grants from the Key Project of the National Science Foundation of China to J.X. (81130047), the National Key Basic Research Program Grant 973 of China to J.X. (2012CB518301), intramural grants from Fudan University to J.X., the National Science Foundation of China to F.L. (81202001), the National Science Foundation of China to X.L. (81202269), Shanghai Municipal Commission of Health and Family Planning to H.J. (XBR2013092) and Shanghai Municipal Education Commission to H.J. (14ZZ010). The BioBank Japan and Japanese GWAS were supported by the Ministry of Education, Culture, Sports, Sciences and Technology of the Japanese government. The GWAS in the MEC was supported by grants CA164973 and HG004726 from the National Institutes of Health. This work was also partially supported by the Ellrodt-Schweighauser Family Chair of Cancer Genomic Research of NorthShore University HealthSystem to J.X.
Publisher Copyright:
© 2015 Macmillan Publishers Limited. All rights reserved.
PY - 2015/10/7
Y1 - 2015/10/7
N2 - Genome-wide association studies (GWAS) have identified 1/4100 genetic loci associated with prostate cancer risk. Less than a dozen of these loci were initially identified from GWAS in two Asian populations, likely because of smaller sample sizes of these individual GWAS in Asians. Here, we conduct a large-scale meta-analysis of two GWAS from the Japanese population (1,583 cases and 3,386 controls) and the Chinese population (1,417 cases and 1,008 controls), followed by replication in three independent sample sets. We identify two independent susceptibility loci for prostate cancer at 11p15.4 (rs12791447, P=3.59 × 10-8; PPFIBP2) and 14q23.2 (rs58262369, P=6.05 × 10-10; ESR2). The mRNA levels of PPFIBP2 and ESR2 are differentially expressed in prostate tumours and paired normal tissues. Our study adds two new loci to the limited number of prostate cancer risk-associated variants in Asians and provides important insight into potential biological mechanisms of prostate cancer.
AB - Genome-wide association studies (GWAS) have identified 1/4100 genetic loci associated with prostate cancer risk. Less than a dozen of these loci were initially identified from GWAS in two Asian populations, likely because of smaller sample sizes of these individual GWAS in Asians. Here, we conduct a large-scale meta-analysis of two GWAS from the Japanese population (1,583 cases and 3,386 controls) and the Chinese population (1,417 cases and 1,008 controls), followed by replication in three independent sample sets. We identify two independent susceptibility loci for prostate cancer at 11p15.4 (rs12791447, P=3.59 × 10-8; PPFIBP2) and 14q23.2 (rs58262369, P=6.05 × 10-10; ESR2). The mRNA levels of PPFIBP2 and ESR2 are differentially expressed in prostate tumours and paired normal tissues. Our study adds two new loci to the limited number of prostate cancer risk-associated variants in Asians and provides important insight into potential biological mechanisms of prostate cancer.
UR - http://www.scopus.com/inward/record.url?scp=84943803328&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84943803328&partnerID=8YFLogxK
U2 - 10.1038/ncomms9469
DO - 10.1038/ncomms9469
M3 - Article
C2 - 26443449
AN - SCOPUS:84943803328
VL - 6
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
M1 - 8469
ER -