Late effects post-allogeneic hematopoietic stem cell transplantation

Shahrukh K. Hashmi, Yoshihiro Inamoto

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Advances in allogeneic hematopoietic cell transplantation (HCT) have increased the curative potential of the procedure and HCT survivors are living longer at a cost of a higher burden of late complications. This chapter discusses the basic concepts of non-relapse late effects, including the role of chronic graft-versus-host disease (cGVHD) in late effects. The late effects of cGVHD occur in a nonsystematic fashion. The exact pathogenesis of the late effects manifested as organ-specific cGVHD are complex. The risks of acute infections are heightened by mucocutaneous damage, which occurs due to skin, oral, and gastrointestinal cGVHD, and due to iatrogenic reasons. The oral mucosal involvement with GVHD frequently leads to extreme xerostomia, often resulting in pain secondary to aphthous-like ulcers. Late liver effects following allogeneic-HCT include cGVHD, viral hepatitis, and drug-induced hepatitis. The HCT survivors and their caregivers are at a significant risk of psychological disorders.

Original languageEnglish
Title of host publicationBlood and Marrow Transplantation Long Term Management
Subtitle of host publicationSurvivorship after Transplant: Second Edition
Publisherwiley
Pages38-46
Number of pages9
ISBN (Electronic)9781119612780
ISBN (Print)9781119612698
DOIs
Publication statusPublished - 01-01-2021
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Medicine

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