Left ventricular assist device-associated endocarditis involving multiple clones of Staphylococcus aureus with distinct antimicrobial susceptibility patterns

Sohei Harada; Kotaro Aoki; Koh Okamoto; Osamu Kinoshita; Kan Nawata; Yoshikazu Ishii; Kazuhiro Tateda; Masakazu Sasaki; Tomoo Saga; Yohei Doi; Hiroshi Yotsuyanagi; Kyoji Moriya; Minoru Ono

doi:10.1016/j.ijid.2019.05.001

Left ventricular assist device-associated endocarditis involving multiple clones of Staphylococcus aureus with distinct antimicrobial susceptibility patterns

Sohei Harada
, Kotaro Aoki
, Koh Okamoto
, Osamu Kinoshita
, Kan Nawata
, Yoshikazu Ishii
, Kazuhiro Tateda
, Masakazu Sasaki
, Tomoo Saga
, Yohei Doi
, Hiroshi Yotsuyanagi
, Kyoji Moriya
, Minoru Ono

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

The case of a patient with left ventricular assist device (LVAD)-associated endocarditis involving multiple clones of Staphylococcus aureus is presented. Different clones with distinct colony morphology were identified from blood cultures collected on the same day and showed diverse antimicrobial resistance patterns. In addition, a difference in antimicrobial susceptibility was observed even within an identical clone recovered 400 days apart due to the loss of SCCmec for methicillin and modification of the 23S rRNA target site for linezolid during a long-term treatment course.

Original language	English
Pages (from-to)	44-47
Number of pages	4
Journal	International Journal of Infectious Diseases
Volume	84
DOIs	https://doi.org/10.1016/j.ijid.2019.05.001
Publication status	Published - 07-2019
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Microbiology (medical)
Infectious Diseases

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10.1016/j.ijid.2019.05.001

Cite this

Harada, S., Aoki, K., Okamoto, K., Kinoshita, O., Nawata, K., Ishii, Y., Tateda, K., Sasaki, M., Saga, T., Doi, Y., Yotsuyanagi, H., Moriya, K., & Ono, M. (2019). Left ventricular assist device-associated endocarditis involving multiple clones of Staphylococcus aureus with distinct antimicrobial susceptibility patterns. International Journal of Infectious Diseases, 84, 44-47. https://doi.org/10.1016/j.ijid.2019.05.001

@article{eb1d241812cb4fbe90acfbde216190e6,

title = "Left ventricular assist device-associated endocarditis involving multiple clones of Staphylococcus aureus with distinct antimicrobial susceptibility patterns",

abstract = "The case of a patient with left ventricular assist device (LVAD)-associated endocarditis involving multiple clones of Staphylococcus aureus is presented. Different clones with distinct colony morphology were identified from blood cultures collected on the same day and showed diverse antimicrobial resistance patterns. In addition, a difference in antimicrobial susceptibility was observed even within an identical clone recovered 400 days apart due to the loss of SCCmec for methicillin and modification of the 23S rRNA target site for linezolid during a long-term treatment course.",

keywords = "Endocarditis, Left ventricular assist device, Linezolid resistance, Staphylococcus aureus, Whole-genome sequencing",

author = "Sohei Harada and Kotaro Aoki and Koh Okamoto and Osamu Kinoshita and Kan Nawata and Yoshikazu Ishii and Kazuhiro Tateda and Masakazu Sasaki and Tomoo Saga and Yohei Doi and Hiroshi Yotsuyanagi and Kyoji Moriya and Minoru Ono",

note = "Publisher Copyright: {\textcopyright} 2019 The Author(s)",

year = "2019",

month = jul,

doi = "10.1016/j.ijid.2019.05.001",

language = "English",

volume = "84",

pages = "44--47",

journal = "International Journal of Infectious Diseases",

issn = "1201-9712",

publisher = "Elsevier B.V.",

}

Harada, S, Aoki, K, Okamoto, K, Kinoshita, O, Nawata, K, Ishii, Y, Tateda, K, Sasaki, M, Saga, T, Doi, Y, Yotsuyanagi, H, Moriya, K & Ono, M 2019, 'Left ventricular assist device-associated endocarditis involving multiple clones of Staphylococcus aureus with distinct antimicrobial susceptibility patterns', International Journal of Infectious Diseases, vol. 84, pp. 44-47. https://doi.org/10.1016/j.ijid.2019.05.001

TY - JOUR

T1 - Left ventricular assist device-associated endocarditis involving multiple clones of Staphylococcus aureus with distinct antimicrobial susceptibility patterns

AU - Harada, Sohei

AU - Aoki, Kotaro

AU - Okamoto, Koh

AU - Kinoshita, Osamu

AU - Nawata, Kan

AU - Ishii, Yoshikazu

AU - Tateda, Kazuhiro

AU - Sasaki, Masakazu

AU - Saga, Tomoo

AU - Doi, Yohei

AU - Yotsuyanagi, Hiroshi

AU - Moriya, Kyoji

AU - Ono, Minoru

PY - 2019/7

Y1 - 2019/7

N2 - The case of a patient with left ventricular assist device (LVAD)-associated endocarditis involving multiple clones of Staphylococcus aureus is presented. Different clones with distinct colony morphology were identified from blood cultures collected on the same day and showed diverse antimicrobial resistance patterns. In addition, a difference in antimicrobial susceptibility was observed even within an identical clone recovered 400 days apart due to the loss of SCCmec for methicillin and modification of the 23S rRNA target site for linezolid during a long-term treatment course.

AB - The case of a patient with left ventricular assist device (LVAD)-associated endocarditis involving multiple clones of Staphylococcus aureus is presented. Different clones with distinct colony morphology were identified from blood cultures collected on the same day and showed diverse antimicrobial resistance patterns. In addition, a difference in antimicrobial susceptibility was observed even within an identical clone recovered 400 days apart due to the loss of SCCmec for methicillin and modification of the 23S rRNA target site for linezolid during a long-term treatment course.

KW - Endocarditis

KW - Left ventricular assist device

KW - Linezolid resistance

KW - Staphylococcus aureus

KW - Whole-genome sequencing

UR - https://www.scopus.com/pages/publications/85065861307

UR - https://www.scopus.com/pages/publications/85065861307#tab=citedBy

U2 - 10.1016/j.ijid.2019.05.001

DO - 10.1016/j.ijid.2019.05.001

M3 - Article

C2 - 31075509

AN - SCOPUS:85065861307

SN - 1201-9712

VL - 84

SP - 44

EP - 47

JO - International Journal of Infectious Diseases

JF - International Journal of Infectious Diseases

ER -

Left ventricular assist device-associated endocarditis involving multiple clones of Staphylococcus aureus with distinct antimicrobial susceptibility patterns

Abstract

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All Science Journal Classification (ASJC) codes

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