Leptin is associated with an increased female colorectal cancer risk

A nested case-control study in Japan

Koji Tamakoshi, Hideaki Toyoshima, Kenji Wakai, Masayo Kojima, Koji Suzuki, Yoshiyuki Watanabe, Norihiko Hayakawa, Hiroshi Yatsuya, Takaaki Kondo, Shinkan Tokudome, Shuji Hashimoto, Sadao Suzuki, Miyuki Kawado, Kotaro Ozasa, Yoshinori Ito, Akiko Tamakoshi

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Objective: To elucidate whether leptin is involved in the etiology of female colorectal cancer. Methods: A case-control study nested in the Japan Collaborative Cohort Study. We compared serum leptin levels in 58 cases of female colorectal cancer with those in 145 controls matched for study area and age. Data were analyzed using a conditional logistic regression model with adjustments for known risk factors for the development of colorectal cancer. Quintile cutoff points were determined on the distribution of leptin levels in cases and controls combined. Results: Serum geometric mean levels of leptin were 6.88 ng/ml in cases and 6.00 ng/ml in controls. The odds ratios of female colorectal cancer risk were 1.40 (95% confidence interval, CI: 0.41-4.78) for the category of the second and third quintiles combined, and 4.84 (CI: 1.29-18.1) for the category of the fourth and fifth quintiles combined relative to the first quintile after adjustment for body mass index (BMI), life-style factors, reproductive factors, and hormonal variables including insulin-like growth factor and its binding protein. Conclusion: Our results suggest that leptin most likely increases the risk of female colorectal cancer substantially independent of BMI.

Original languageEnglish
Pages (from-to)454-461
Number of pages8
JournalOncology
Volume68
Issue number4-6
DOIs
Publication statusPublished - 01-08-2005

Fingerprint

Leptin
Case-Control Studies
Colorectal Neoplasms
Japan
Body Mass Index
Logistic Models
Insulin-Like Growth Factor Binding Proteins
Serum
Life Style
Cohort Studies
Odds Ratio
Confidence Intervals

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Tamakoshi, K., Toyoshima, H., Wakai, K., Kojima, M., Suzuki, K., Watanabe, Y., ... Tamakoshi, A. (2005). Leptin is associated with an increased female colorectal cancer risk: A nested case-control study in Japan. Oncology, 68(4-6), 454-461. https://doi.org/10.1159/000086988
Tamakoshi, Koji ; Toyoshima, Hideaki ; Wakai, Kenji ; Kojima, Masayo ; Suzuki, Koji ; Watanabe, Yoshiyuki ; Hayakawa, Norihiko ; Yatsuya, Hiroshi ; Kondo, Takaaki ; Tokudome, Shinkan ; Hashimoto, Shuji ; Suzuki, Sadao ; Kawado, Miyuki ; Ozasa, Kotaro ; Ito, Yoshinori ; Tamakoshi, Akiko. / Leptin is associated with an increased female colorectal cancer risk : A nested case-control study in Japan. In: Oncology. 2005 ; Vol. 68, No. 4-6. pp. 454-461.
@article{afd5d85dfb1242eaa85f7e0acd1d59be,
title = "Leptin is associated with an increased female colorectal cancer risk: A nested case-control study in Japan",
abstract = "Objective: To elucidate whether leptin is involved in the etiology of female colorectal cancer. Methods: A case-control study nested in the Japan Collaborative Cohort Study. We compared serum leptin levels in 58 cases of female colorectal cancer with those in 145 controls matched for study area and age. Data were analyzed using a conditional logistic regression model with adjustments for known risk factors for the development of colorectal cancer. Quintile cutoff points were determined on the distribution of leptin levels in cases and controls combined. Results: Serum geometric mean levels of leptin were 6.88 ng/ml in cases and 6.00 ng/ml in controls. The odds ratios of female colorectal cancer risk were 1.40 (95{\%} confidence interval, CI: 0.41-4.78) for the category of the second and third quintiles combined, and 4.84 (CI: 1.29-18.1) for the category of the fourth and fifth quintiles combined relative to the first quintile after adjustment for body mass index (BMI), life-style factors, reproductive factors, and hormonal variables including insulin-like growth factor and its binding protein. Conclusion: Our results suggest that leptin most likely increases the risk of female colorectal cancer substantially independent of BMI.",
author = "Koji Tamakoshi and Hideaki Toyoshima and Kenji Wakai and Masayo Kojima and Koji Suzuki and Yoshiyuki Watanabe and Norihiko Hayakawa and Hiroshi Yatsuya and Takaaki Kondo and Shinkan Tokudome and Shuji Hashimoto and Sadao Suzuki and Miyuki Kawado and Kotaro Ozasa and Yoshinori Ito and Akiko Tamakoshi",
year = "2005",
month = "8",
day = "1",
doi = "10.1159/000086988",
language = "English",
volume = "68",
pages = "454--461",
journal = "Oncology",
issn = "0030-2414",
publisher = "S. Karger AG",
number = "4-6",

}

Tamakoshi, K, Toyoshima, H, Wakai, K, Kojima, M, Suzuki, K, Watanabe, Y, Hayakawa, N, Yatsuya, H, Kondo, T, Tokudome, S, Hashimoto, S, Suzuki, S, Kawado, M, Ozasa, K, Ito, Y & Tamakoshi, A 2005, 'Leptin is associated with an increased female colorectal cancer risk: A nested case-control study in Japan', Oncology, vol. 68, no. 4-6, pp. 454-461. https://doi.org/10.1159/000086988

Leptin is associated with an increased female colorectal cancer risk : A nested case-control study in Japan. / Tamakoshi, Koji; Toyoshima, Hideaki; Wakai, Kenji; Kojima, Masayo; Suzuki, Koji; Watanabe, Yoshiyuki; Hayakawa, Norihiko; Yatsuya, Hiroshi; Kondo, Takaaki; Tokudome, Shinkan; Hashimoto, Shuji; Suzuki, Sadao; Kawado, Miyuki; Ozasa, Kotaro; Ito, Yoshinori; Tamakoshi, Akiko.

In: Oncology, Vol. 68, No. 4-6, 01.08.2005, p. 454-461.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Leptin is associated with an increased female colorectal cancer risk

T2 - A nested case-control study in Japan

AU - Tamakoshi, Koji

AU - Toyoshima, Hideaki

AU - Wakai, Kenji

AU - Kojima, Masayo

AU - Suzuki, Koji

AU - Watanabe, Yoshiyuki

AU - Hayakawa, Norihiko

AU - Yatsuya, Hiroshi

AU - Kondo, Takaaki

AU - Tokudome, Shinkan

AU - Hashimoto, Shuji

AU - Suzuki, Sadao

AU - Kawado, Miyuki

AU - Ozasa, Kotaro

AU - Ito, Yoshinori

AU - Tamakoshi, Akiko

PY - 2005/8/1

Y1 - 2005/8/1

N2 - Objective: To elucidate whether leptin is involved in the etiology of female colorectal cancer. Methods: A case-control study nested in the Japan Collaborative Cohort Study. We compared serum leptin levels in 58 cases of female colorectal cancer with those in 145 controls matched for study area and age. Data were analyzed using a conditional logistic regression model with adjustments for known risk factors for the development of colorectal cancer. Quintile cutoff points were determined on the distribution of leptin levels in cases and controls combined. Results: Serum geometric mean levels of leptin were 6.88 ng/ml in cases and 6.00 ng/ml in controls. The odds ratios of female colorectal cancer risk were 1.40 (95% confidence interval, CI: 0.41-4.78) for the category of the second and third quintiles combined, and 4.84 (CI: 1.29-18.1) for the category of the fourth and fifth quintiles combined relative to the first quintile after adjustment for body mass index (BMI), life-style factors, reproductive factors, and hormonal variables including insulin-like growth factor and its binding protein. Conclusion: Our results suggest that leptin most likely increases the risk of female colorectal cancer substantially independent of BMI.

AB - Objective: To elucidate whether leptin is involved in the etiology of female colorectal cancer. Methods: A case-control study nested in the Japan Collaborative Cohort Study. We compared serum leptin levels in 58 cases of female colorectal cancer with those in 145 controls matched for study area and age. Data were analyzed using a conditional logistic regression model with adjustments for known risk factors for the development of colorectal cancer. Quintile cutoff points were determined on the distribution of leptin levels in cases and controls combined. Results: Serum geometric mean levels of leptin were 6.88 ng/ml in cases and 6.00 ng/ml in controls. The odds ratios of female colorectal cancer risk were 1.40 (95% confidence interval, CI: 0.41-4.78) for the category of the second and third quintiles combined, and 4.84 (CI: 1.29-18.1) for the category of the fourth and fifth quintiles combined relative to the first quintile after adjustment for body mass index (BMI), life-style factors, reproductive factors, and hormonal variables including insulin-like growth factor and its binding protein. Conclusion: Our results suggest that leptin most likely increases the risk of female colorectal cancer substantially independent of BMI.

UR - http://www.scopus.com/inward/record.url?scp=23844505956&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=23844505956&partnerID=8YFLogxK

U2 - 10.1159/000086988

DO - 10.1159/000086988

M3 - Article

VL - 68

SP - 454

EP - 461

JO - Oncology

JF - Oncology

SN - 0030-2414

IS - 4-6

ER -