Leptin is associated with an increased female colorectal cancer risk: A nested case-control study in Japan

Koji Tamakoshi, Hideaki Toyoshima, Kenji Wakai, Masayo Kojima, Koji Suzuki, Yoshiyuki Watanabe, Norihiko Hayakawa, Hiroshi Yatsuya, Takaaki Kondo, Shinkan Tokudome, Shuji Hashimoto, Sadao Suzuki, Miyuki Kawado, Kotaro Ozasa, Yoshinori Ito, Akiko Tamakoshi

Research output: Contribution to journalArticlepeer-review

86 Citations (Scopus)


Objective: To elucidate whether leptin is involved in the etiology of female colorectal cancer. Methods: A case-control study nested in the Japan Collaborative Cohort Study. We compared serum leptin levels in 58 cases of female colorectal cancer with those in 145 controls matched for study area and age. Data were analyzed using a conditional logistic regression model with adjustments for known risk factors for the development of colorectal cancer. Quintile cutoff points were determined on the distribution of leptin levels in cases and controls combined. Results: Serum geometric mean levels of leptin were 6.88 ng/ml in cases and 6.00 ng/ml in controls. The odds ratios of female colorectal cancer risk were 1.40 (95% confidence interval, CI: 0.41-4.78) for the category of the second and third quintiles combined, and 4.84 (CI: 1.29-18.1) for the category of the fourth and fifth quintiles combined relative to the first quintile after adjustment for body mass index (BMI), life-style factors, reproductive factors, and hormonal variables including insulin-like growth factor and its binding protein. Conclusion: Our results suggest that leptin most likely increases the risk of female colorectal cancer substantially independent of BMI.

Original languageEnglish
Pages (from-to)454-461
Number of pages8
Issue number4-6
Publication statusPublished - 08-2005

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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