Lesion of area postrema attenuated hyperphagic responses to glucoprivation, but not transcriptional activation of the neuropeptide y gene in rats

Yoshiharu Ozawa, Hiroshi Arima, Ryoichi Banno, Yoshihiro Ito, Motomitsu Goto, Yoshiaki Morishita, Yoshihisa Sugimura, Nobuaki Ozaki, Hiroshi Nagasaki, Yutaka Oiso

Research output: Contribution to journalArticle

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Abstract

The area postrema (AP) is a circumventricular organ that lacks a blood-brain barrier. Previous studies have shown that the lesion of AP (APX) attenuated hyperphagic responses to glucoprivation. As the orexigenic neuropeptide Y (NPY) neurons have been implicated in the regulation of food intake, we examined whether the activation of NPY neurons by glucoprivation is mediated through the AP as well. In agreement with previous studies, hyperphagic responses to an injection of 2-deoxy-D-glucose that blocks glucose utilization were significantly attenuated in the APX group compared with the sham-operated (Sham) group. However, the expression levels of NPY heteronuclear RNA, a sensitive indicator for the gene transcription, were significantly increased in the arcuate nucleus by a 2-deoxy-D-glucose injection in both the APX and the Sham groups, and there were no significant differences in the values between groups. These data suggest that the hyperphagic response to glucoprivation, but not the activation of NPY gene transcription in the arcuate nucleus, was mediated through the AP in the hindbrain.

Original languageEnglish
Pages (from-to)673-675
Number of pages3
JournalNeuroReport
Volume23
Issue number11
DOIs
Publication statusPublished - 01-08-2012

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Area Postrema
Neuropeptide Y
Neuropeptides
Transcriptional Activation
Arcuate Nucleus of Hypothalamus
Deoxyglucose
Genes
Appetite Regulation
Neurons
Rhombencephalon
Injections
Blood-Brain Barrier
RNA
Glucose

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Ozawa, Yoshiharu ; Arima, Hiroshi ; Banno, Ryoichi ; Ito, Yoshihiro ; Goto, Motomitsu ; Morishita, Yoshiaki ; Sugimura, Yoshihisa ; Ozaki, Nobuaki ; Nagasaki, Hiroshi ; Oiso, Yutaka. / Lesion of area postrema attenuated hyperphagic responses to glucoprivation, but not transcriptional activation of the neuropeptide y gene in rats. In: NeuroReport. 2012 ; Vol. 23, No. 11. pp. 673-675.
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Lesion of area postrema attenuated hyperphagic responses to glucoprivation, but not transcriptional activation of the neuropeptide y gene in rats. / Ozawa, Yoshiharu; Arima, Hiroshi; Banno, Ryoichi; Ito, Yoshihiro; Goto, Motomitsu; Morishita, Yoshiaki; Sugimura, Yoshihisa; Ozaki, Nobuaki; Nagasaki, Hiroshi; Oiso, Yutaka.

In: NeuroReport, Vol. 23, No. 11, 01.08.2012, p. 673-675.

Research output: Contribution to journalArticle

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AU - Sugimura, Yoshihisa

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AU - Oiso, Yutaka

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