TY - JOUR
T1 - Leukemia inhibitory factor stimulates vasopressin release in rats
AU - Ishizaki, Seiji
AU - Murase, Takashi
AU - Sugimura, Yoshihisa
AU - Banno, Ryoichi
AU - Arima, Hiroshi
AU - Miura, Yoshitaka
AU - Oiso, Yutaka
PY - 2004/4/8
Y1 - 2004/4/8
N2 - Leukemia inhibitory factor (LIF) is a cytokine of the interleukin-6 family exhibiting diverse physiological functions during inflammatory stress. It is well known that syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is often associated with inflammatory disease, and cytokines produced at inflammatory foci are thought to stimulate arginine vasopressin (AVP) release. In the present study, we investigated the effects of centrally administered LIF on AVP release in conscious rats. Intracerebroventricular administration of LIF (0.01-1.0 μg/rat) significantly increased the plasma AVP concentration, and its effect was observed from 5 to 60 min after the injection. LIF did not cause significant changes in plasma Na+, total protein and blood pressure. There were no significant changes in the plasma AVP concentration after intravenous injection of LIF (1.0, 3.0 μg/rat). These results indicate that LIF plays a stimulatory role in the regulation of AVP release, and suggest the possibility that LIF may be involved in the pathogenesis of SIADH.
AB - Leukemia inhibitory factor (LIF) is a cytokine of the interleukin-6 family exhibiting diverse physiological functions during inflammatory stress. It is well known that syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is often associated with inflammatory disease, and cytokines produced at inflammatory foci are thought to stimulate arginine vasopressin (AVP) release. In the present study, we investigated the effects of centrally administered LIF on AVP release in conscious rats. Intracerebroventricular administration of LIF (0.01-1.0 μg/rat) significantly increased the plasma AVP concentration, and its effect was observed from 5 to 60 min after the injection. LIF did not cause significant changes in plasma Na+, total protein and blood pressure. There were no significant changes in the plasma AVP concentration after intravenous injection of LIF (1.0, 3.0 μg/rat). These results indicate that LIF plays a stimulatory role in the regulation of AVP release, and suggest the possibility that LIF may be involved in the pathogenesis of SIADH.
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U2 - 10.1016/j.neulet.2004.02.019
DO - 10.1016/j.neulet.2004.02.019
M3 - Article
C2 - 15050716
AN - SCOPUS:1842452029
SN - 0304-3940
VL - 359
SP - 77
EP - 80
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 1-2
ER -