TY - JOUR
T1 - Leukocytosis and thrombocytosis as prognostic factors for women with uterine cervical cancer
AU - Murata, Y.
AU - Miyahara, Y.
AU - Suzuki, K.
AU - Wakahashi, S.
AU - Sudo, T.
AU - Nagao, S.
AU - Yamaguchi, S.
AU - Ebina, Y.
AU - Yamada, H.
N1 - Publisher Copyright:
© 2020 Murata et al. Published by IMR Press
PY - 2020/2/15
Y1 - 2020/2/15
N2 - Purpose of Investigation: The aim of this study was to evaluate whether leukocytosis and thrombocytosis prior to treatment was associated with the prognosis of women with uterine cervical cancer. Materials and Methods: The authors assessed 2,267 women who were diagnosed as having FIGO Stages I-IV uterine cervical cancer and were followed up for at least five years. The age, clinical stage, histology, leukocytosis, and thrombocytosis at the initial diagnosis were evaluated for overall survival (OS). Results: Leukocytosis and thrombocytosis were identified in 315 and in 134 women, respectively. Fifty-eight had both conditions. Multivariable analysis revealed that age [hazard ratio (HR) 1.7, p < 0.001], advanced FIGO Stage (4.8, p < 0.001), histology (2.0, p < 0.001), leukocytosis (1.5, p < 0.01), and thrombocytosis (2.0, p < 0.01) were independent factors for decreased OS. OS of women with both thrombocytosis and leukocy-tosis was the worst (p < 0.01). Conclusion: Leukocytosis and thrombocytosis were independently associated with decreased OS in women with uterine cervical cancer.
AB - Purpose of Investigation: The aim of this study was to evaluate whether leukocytosis and thrombocytosis prior to treatment was associated with the prognosis of women with uterine cervical cancer. Materials and Methods: The authors assessed 2,267 women who were diagnosed as having FIGO Stages I-IV uterine cervical cancer and were followed up for at least five years. The age, clinical stage, histology, leukocytosis, and thrombocytosis at the initial diagnosis were evaluated for overall survival (OS). Results: Leukocytosis and thrombocytosis were identified in 315 and in 134 women, respectively. Fifty-eight had both conditions. Multivariable analysis revealed that age [hazard ratio (HR) 1.7, p < 0.001], advanced FIGO Stage (4.8, p < 0.001), histology (2.0, p < 0.001), leukocytosis (1.5, p < 0.01), and thrombocytosis (2.0, p < 0.01) were independent factors for decreased OS. OS of women with both thrombocytosis and leukocy-tosis was the worst (p < 0.01). Conclusion: Leukocytosis and thrombocytosis were independently associated with decreased OS in women with uterine cervical cancer.
KW - Cervical cancer
KW - Leukocytosis
KW - Prognosis
KW - Thrombocytosis
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U2 - 10.31083/j.ejgo.2020.01.4886
DO - 10.31083/j.ejgo.2020.01.4886
M3 - Article
AN - SCOPUS:85085610666
SN - 0392-2936
VL - 41
SP - 93
EP - 97
JO - European Journal of Gynaecological Oncology
JF - European Journal of Gynaecological Oncology
IS - 1
ER -
