TY - JOUR
T1 - Lifecycles of EBV and cancer
AU - Murata, Takayuki
N1 - Copyright:
This record is sourced from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
PY - 2014
Y1 - 2014
N2 - Epstein-Barr virus (EBV) is a member of gamma-herpesvirus, which can cause various types of tumor. Coexisting with the host for a long period of time, it has evolved unique and sophisticated strategy for survival by taking complicated, tactical modes of infection. Such modes include latent and lytic infections, and latent state is further categorized into four types. Differences and transitions in such lifestyles are significantly associated not only with virus amplification, but also with pathology and advancement of the disorders. I here review oncogenesis and pathogenesis of EBV-related disorders, especially focusing on our recent results on the modes of EBV infection.
AB - Epstein-Barr virus (EBV) is a member of gamma-herpesvirus, which can cause various types of tumor. Coexisting with the host for a long period of time, it has evolved unique and sophisticated strategy for survival by taking complicated, tactical modes of infection. Such modes include latent and lytic infections, and latent state is further categorized into four types. Differences and transitions in such lifestyles are significantly associated not only with virus amplification, but also with pathology and advancement of the disorders. I here review oncogenesis and pathogenesis of EBV-related disorders, especially focusing on our recent results on the modes of EBV infection.
UR - http://www.scopus.com/inward/record.url?scp=84946215832&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84946215832&partnerID=8YFLogxK
U2 - 10.2222/jsv.64.95
DO - 10.2222/jsv.64.95
M3 - Review article
C2 - 25765985
AN - SCOPUS:84946215832
VL - 64
SP - 95
EP - 104
JO - Uirusu. Journal of virology
JF - Uirusu. Journal of virology
SN - 0042-6857
IS - 1
ER -