Linkage disequilibrium and association with methamphetamine dependence/psychosis of μ-opioid receptor gene polymorphisms

S. Ide, H. Kobayashi, H. Ujike, N. Ozaki, Y. Sekine, T. Inada, M. Harano, T. Komiyama, M. Yamada, M. Iyo, N. Iwata, K. Tanaka, H. Shen, K. Iwahashi, M. Itokawa, M. Minami, M. Satoh, K. Ikeda, Ide Sora

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Abstract

Several studies indicate that the μ-opioid receptor plays a role in addiction not only to opiate drugs but also to alcohol and non-opiate addictive drugs. Our studies aim to reveal the associations between gene polymorphisms and methamphetamine (MAP) dependence/psychosis. We newly identified several polymorphisms and four substantial linkage disequilibrium (LD) blocks in the μ-opioid receptor (OPRM1) gene. We found significant differences in both genotype and allele frequencies of the single-nucleotide polymorphism (SNP) IVS2 + G691C between control (n=232) and MAP-dependent/psychotic patients (n=128). There was also a significant association between IVS2 + G691C and patients with transient psychosis. These results suggest that the OPRM1 gene variations may be a factor in development and prognosis of MAP psychosis.

Original languageEnglish
Pages (from-to)179-188
Number of pages10
JournalPharmacogenomics Journal
Volume6
Issue number3
DOIs
Publication statusPublished - 01-05-2006

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All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Genetics
  • Pharmacology

Cite this

Ide, S., Kobayashi, H., Ujike, H., Ozaki, N., Sekine, Y., Inada, T., Harano, M., Komiyama, T., Yamada, M., Iyo, M., Iwata, N., Tanaka, K., Shen, H., Iwahashi, K., Itokawa, M., Minami, M., Satoh, M., Ikeda, K., & Sora, I. (2006). Linkage disequilibrium and association with methamphetamine dependence/psychosis of μ-opioid receptor gene polymorphisms. Pharmacogenomics Journal, 6(3), 179-188. https://doi.org/10.1038/sj.tpj.6500355