Linkage disequilibrium and association with methamphetamine dependence/psychosis of μ-opioid receptor gene polymorphisms

S. Ide; H. Kobayashi; H. Ujike; N. Ozaki; Y. Sekine; T. Inada; M. Harano; T. Komiyama; M. Yamada; M. Iyo; N. Iwata; K. Tanaka; H. Shen; K. Iwahashi; M. Itokawa; M. Minami; M. Satoh; K. Ikeda; Ide Sora

doi:10.1038/sj.tpj.6500355

Linkage disequilibrium and association with methamphetamine dependence/psychosis of μ-opioid receptor gene polymorphisms

S. Ide, H. Kobayashi, H. Ujike, N. Ozaki, Y. Sekine, T. Inada, M. Harano, T. Komiyama, M. Yamada, M. Iyo, N. Iwata, K. Tanaka, H. Shen, K. Iwahashi, M. Itokawa, M. Minami, M. Satoh, K. Ikeda, Ide Sora

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Abstract

Several studies indicate that the μ-opioid receptor plays a role in addiction not only to opiate drugs but also to alcohol and non-opiate addictive drugs. Our studies aim to reveal the associations between gene polymorphisms and methamphetamine (MAP) dependence/psychosis. We newly identified several polymorphisms and four substantial linkage disequilibrium (LD) blocks in the μ-opioid receptor (OPRM1) gene. We found significant differences in both genotype and allele frequencies of the single-nucleotide polymorphism (SNP) IVS2 + G691C between control (n=232) and MAP-dependent/psychotic patients (n=128). There was also a significant association between IVS2 + G691C and patients with transient psychosis. These results suggest that the OPRM1 gene variations may be a factor in development and prognosis of MAP psychosis.

Original language	English
Pages (from-to)	179-188
Number of pages	10
Journal	Pharmacogenomics Journal
Volume	6
Issue number	3
DOIs	https://doi.org/10.1038/sj.tpj.6500355
Publication status	Published - 05-2006
Externally published	Yes

All Science Journal Classification (ASJC) codes

Molecular Medicine
Genetics
Pharmacology

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Ide, S., Kobayashi, H., Ujike, H., Ozaki, N., Sekine, Y., Inada, T., Harano, M., Komiyama, T., Yamada, M., Iyo, M., Iwata, N., Tanaka, K., Shen, H., Iwahashi, K., Itokawa, M., Minami, M., Satoh, M., Ikeda, K., & Sora, I. (2006). Linkage disequilibrium and association with methamphetamine dependence/psychosis of μ-opioid receptor gene polymorphisms. Pharmacogenomics Journal, 6(3), 179-188. https://doi.org/10.1038/sj.tpj.6500355

@article{ac5d038fecf944a78b3d00f2e637ce4b,

title = "Linkage disequilibrium and association with methamphetamine dependence/psychosis of μ-opioid receptor gene polymorphisms",

abstract = "Several studies indicate that the μ-opioid receptor plays a role in addiction not only to opiate drugs but also to alcohol and non-opiate addictive drugs. Our studies aim to reveal the associations between gene polymorphisms and methamphetamine (MAP) dependence/psychosis. We newly identified several polymorphisms and four substantial linkage disequilibrium (LD) blocks in the μ-opioid receptor (OPRM1) gene. We found significant differences in both genotype and allele frequencies of the single-nucleotide polymorphism (SNP) IVS2 + G691C between control (n=232) and MAP-dependent/psychotic patients (n=128). There was also a significant association between IVS2 + G691C and patients with transient psychosis. These results suggest that the OPRM1 gene variations may be a factor in development and prognosis of MAP psychosis.",

keywords = "Dependence, Human μ-opioid receptor, Methamphetamine, Psychosis, Single-nucleotide polymorphism",

author = "S. Ide and H. Kobayashi and H. Ujike and N. Ozaki and Y. Sekine and T. Inada and M. Harano and T. Komiyama and M. Yamada and M. Iyo and N. Iwata and K. Tanaka and H. Shen and K. Iwahashi and M. Itokawa and M. Minami and M. Satoh and K. Ikeda and Ide Sora",

note = "Funding Information: We are grateful to the Japanese Ministry of Health, Labour and Welfare (MHLW) as well as to the Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT) for support in part by Grants MHLW13-040, MHLW15-7, MHLW17-pharmaco-001, MEXT15025206 and MEXT15029204.",

year = "2006",

month = may,

doi = "10.1038/sj.tpj.6500355",

language = "English",

volume = "6",

pages = "179--188",

journal = "Pharmacogenomics Journal",

issn = "1470-269X",

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Ide, S, Kobayashi, H, Ujike, H, Ozaki, N, Sekine, Y, Inada, T, Harano, M, Komiyama, T, Yamada, M, Iyo, M, Iwata, N, Tanaka, K, Shen, H, Iwahashi, K, Itokawa, M, Minami, M, Satoh, M, Ikeda, K & Sora, I 2006, 'Linkage disequilibrium and association with methamphetamine dependence/psychosis of μ-opioid receptor gene polymorphisms', Pharmacogenomics Journal, vol. 6, no. 3, pp. 179-188. https://doi.org/10.1038/sj.tpj.6500355

TY - JOUR

T1 - Linkage disequilibrium and association with methamphetamine dependence/psychosis of μ-opioid receptor gene polymorphisms

AU - Ide, S.

AU - Kobayashi, H.

AU - Ujike, H.

AU - Ozaki, N.

AU - Sekine, Y.

AU - Inada, T.

AU - Harano, M.

AU - Komiyama, T.

AU - Yamada, M.

AU - Iyo, M.

AU - Iwata, N.

AU - Tanaka, K.

AU - Shen, H.

AU - Iwahashi, K.

AU - Itokawa, M.

AU - Minami, M.

AU - Satoh, M.

AU - Ikeda, K.

AU - Sora, Ide

N1 - Funding Information: We are grateful to the Japanese Ministry of Health, Labour and Welfare (MHLW) as well as to the Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT) for support in part by Grants MHLW13-040, MHLW15-7, MHLW17-pharmaco-001, MEXT15025206 and MEXT15029204.

PY - 2006/5

Y1 - 2006/5

N2 - Several studies indicate that the μ-opioid receptor plays a role in addiction not only to opiate drugs but also to alcohol and non-opiate addictive drugs. Our studies aim to reveal the associations between gene polymorphisms and methamphetamine (MAP) dependence/psychosis. We newly identified several polymorphisms and four substantial linkage disequilibrium (LD) blocks in the μ-opioid receptor (OPRM1) gene. We found significant differences in both genotype and allele frequencies of the single-nucleotide polymorphism (SNP) IVS2 + G691C between control (n=232) and MAP-dependent/psychotic patients (n=128). There was also a significant association between IVS2 + G691C and patients with transient psychosis. These results suggest that the OPRM1 gene variations may be a factor in development and prognosis of MAP psychosis.

AB - Several studies indicate that the μ-opioid receptor plays a role in addiction not only to opiate drugs but also to alcohol and non-opiate addictive drugs. Our studies aim to reveal the associations between gene polymorphisms and methamphetamine (MAP) dependence/psychosis. We newly identified several polymorphisms and four substantial linkage disequilibrium (LD) blocks in the μ-opioid receptor (OPRM1) gene. We found significant differences in both genotype and allele frequencies of the single-nucleotide polymorphism (SNP) IVS2 + G691C between control (n=232) and MAP-dependent/psychotic patients (n=128). There was also a significant association between IVS2 + G691C and patients with transient psychosis. These results suggest that the OPRM1 gene variations may be a factor in development and prognosis of MAP psychosis.

KW - Dependence

KW - Human μ-opioid receptor

KW - Methamphetamine

KW - Psychosis

KW - Single-nucleotide polymorphism

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U2 - 10.1038/sj.tpj.6500355

DO - 10.1038/sj.tpj.6500355

M3 - Article

C2 - 16402083

AN - SCOPUS:33744511634

SN - 1470-269X

VL - 6

SP - 179

EP - 188

JO - Pharmacogenomics Journal

JF - Pharmacogenomics Journal

IS - 3

ER -

Linkage disequilibrium and association with methamphetamine dependence/psychosis of μ-opioid receptor gene polymorphisms

Abstract

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