Lipid and lipoprotein components play important roles the egress and infectivity of hepatitis C virions

Takayuki Hishiki; Yuko Shimizu; Saneyuki Ujino; Hironori Nishitsuji; Kunitada Shimotohno

doi:10.1007/978-4-431-56098-2_11

Lipid and lipoprotein components play important roles the egress and infectivity of hepatitis C virions

Takayuki Hishiki, Yuko Shimizu, Saneyuki Ujino, Hironori Nishitsuji, Kunitada Shimotohno

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Persistent hepatitis C virus (HCV) infection is a leading cause of liver diseases, including chronic hepatitis C, progressive liver fibrosis, cirrhosis, and hepatocellular carcinoma. Chronic hepatitis C is strongly associated with lipid accumulation in the hepatocytes. A significant percentage of chronic HCV patients suffer from diabetes and steatosis. Accumulating evidence indicates a strong relationship between lipid metabolism and HCV proliferation. HCV contains lipoprotein components in its envelope, a unique characteristic that results in the lower buoyant density of HCV virions than those of other enveloped viruses. The incorporation of lipoprotein components is required for viral infection. During the egress of HCV, host factors, such as microsomal triglyceride transfer protein, play some role in the association between lipoprotein and a precursor form of HCV. In this chapter, we summarize how HCV uses the processes of lipid metabolism and discuss the importance of lipoprotein components in the viral lifecycle.

Original language	English
Title of host publication	Hepatitis C Virus I
Subtitle of host publication	Cellular and Molecular Virology
Publisher	Springer Japan
Pages	255-272
Number of pages	18
ISBN (Electronic)	9784431560982
ISBN (Print)	9784431560968
DOIs	https://doi.org/10.1007/978-4-431-56098-2_11
Publication status	Published - 01-01-2016
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Medicine
General Immunology and Microbiology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-4-431-56098-2_11

Cite this

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abstract = "Persistent hepatitis C virus (HCV) infection is a leading cause of liver diseases, including chronic hepatitis C, progressive liver fibrosis, cirrhosis, and hepatocellular carcinoma. Chronic hepatitis C is strongly associated with lipid accumulation in the hepatocytes. A significant percentage of chronic HCV patients suffer from diabetes and steatosis. Accumulating evidence indicates a strong relationship between lipid metabolism and HCV proliferation. HCV contains lipoprotein components in its envelope, a unique characteristic that results in the lower buoyant density of HCV virions than those of other enveloped viruses. The incorporation of lipoprotein components is required for viral infection. During the egress of HCV, host factors, such as microsomal triglyceride transfer protein, play some role in the association between lipoprotein and a precursor form of HCV. In this chapter, we summarize how HCV uses the processes of lipid metabolism and discuss the importance of lipoprotein components in the viral lifecycle.",

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AU - Hishiki, Takayuki

AU - Shimizu, Yuko

AU - Ujino, Saneyuki

AU - Nishitsuji, Hironori

AU - Shimotohno, Kunitada

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Persistent hepatitis C virus (HCV) infection is a leading cause of liver diseases, including chronic hepatitis C, progressive liver fibrosis, cirrhosis, and hepatocellular carcinoma. Chronic hepatitis C is strongly associated with lipid accumulation in the hepatocytes. A significant percentage of chronic HCV patients suffer from diabetes and steatosis. Accumulating evidence indicates a strong relationship between lipid metabolism and HCV proliferation. HCV contains lipoprotein components in its envelope, a unique characteristic that results in the lower buoyant density of HCV virions than those of other enveloped viruses. The incorporation of lipoprotein components is required for viral infection. During the egress of HCV, host factors, such as microsomal triglyceride transfer protein, play some role in the association between lipoprotein and a precursor form of HCV. In this chapter, we summarize how HCV uses the processes of lipid metabolism and discuss the importance of lipoprotein components in the viral lifecycle.

AB - Persistent hepatitis C virus (HCV) infection is a leading cause of liver diseases, including chronic hepatitis C, progressive liver fibrosis, cirrhosis, and hepatocellular carcinoma. Chronic hepatitis C is strongly associated with lipid accumulation in the hepatocytes. A significant percentage of chronic HCV patients suffer from diabetes and steatosis. Accumulating evidence indicates a strong relationship between lipid metabolism and HCV proliferation. HCV contains lipoprotein components in its envelope, a unique characteristic that results in the lower buoyant density of HCV virions than those of other enveloped viruses. The incorporation of lipoprotein components is required for viral infection. During the egress of HCV, host factors, such as microsomal triglyceride transfer protein, play some role in the association between lipoprotein and a precursor form of HCV. In this chapter, we summarize how HCV uses the processes of lipid metabolism and discuss the importance of lipoprotein components in the viral lifecycle.

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Lipid and lipoprotein components play important roles the egress and infectivity of hepatitis C virions

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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