Lipid rafts and their possible involvements in neuroimmunological disorders: New research arena

Kunihiko Asakura, Akihiro Ueda, Tatsuro Mutoh

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Multiple sclerosis (MS) and neuromyelitis optica (NMO) are presumed to be an autoimmune disease in the central nervous system (CNS). Although lipids are most abundant components in the nervous system, it has been believed that cellular and/or humoral immunity to various myelin proteins causes these neuroinflammatory diseases. Recent research advances enable us to study lipids in the membranes and some key molecules involved in various neurological disorders including Guillain-Barré syndrome, Alzheimer's disease, Parkinson's disease, and prion disease, are localized in lipid rafts. In MS and NMO, the key molecules for the pathogenesis or the target molecules for the treatments of MS and NMO are also localized in lipid rafts. Here in this article, we highlight on the possible involvement of lipid rafts in the pathogenesis and treatment of MS and NMO and introduce our recent observation of aquaporin 4 regarding NMO.

Original languageEnglish
Pages (from-to)303-313
Number of pages11
JournalFrontiers in Bioscience - Landmark
Volume20
Issue number2
DOIs
Publication statusPublished - 15-01-2015

Fingerprint

Neuromyelitis Optica
Multiple Sclerosis
Lipids
Research
Neurology
Molecules
Aquaporin 4
Myelin Proteins
Prion Diseases
Prions
Membrane Lipids
Humoral Immunity
Nervous System Diseases
Cellular Immunity
Nervous System
Autoimmune Diseases
Parkinson Disease
Alzheimer Disease
Central Nervous System
Observation

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

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Lipid rafts and their possible involvements in neuroimmunological disorders : New research arena. / Asakura, Kunihiko; Ueda, Akihiro; Mutoh, Tatsuro.

In: Frontiers in Bioscience - Landmark, Vol. 20, No. 2, 15.01.2015, p. 303-313.

Research output: Contribution to journalArticle

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