TY - JOUR
T1 - Lipid rafts and their possible involvements in neuroimmunological disorders
T2 - New research arena
AU - Asakura, Kunihiko
AU - Ueda, Akihiro
AU - Mutoh, Tatsuro
N1 - Publisher Copyright:
© 2015, Frontiers in Bioscience. All rights reserved.
PY - 2015/1/15
Y1 - 2015/1/15
N2 - Multiple sclerosis (MS) and neuromyelitis optica (NMO) are presumed to be an autoimmune disease in the central nervous system (CNS). Although lipids are most abundant components in the nervous system, it has been believed that cellular and/or humoral immunity to various myelin proteins causes these neuroinflammatory diseases. Recent research advances enable us to study lipids in the membranes and some key molecules involved in various neurological disorders including Guillain-Barré syndrome, Alzheimer's disease, Parkinson's disease, and prion disease, are localized in lipid rafts. In MS and NMO, the key molecules for the pathogenesis or the target molecules for the treatments of MS and NMO are also localized in lipid rafts. Here in this article, we highlight on the possible involvement of lipid rafts in the pathogenesis and treatment of MS and NMO and introduce our recent observation of aquaporin 4 regarding NMO.
AB - Multiple sclerosis (MS) and neuromyelitis optica (NMO) are presumed to be an autoimmune disease in the central nervous system (CNS). Although lipids are most abundant components in the nervous system, it has been believed that cellular and/or humoral immunity to various myelin proteins causes these neuroinflammatory diseases. Recent research advances enable us to study lipids in the membranes and some key molecules involved in various neurological disorders including Guillain-Barré syndrome, Alzheimer's disease, Parkinson's disease, and prion disease, are localized in lipid rafts. In MS and NMO, the key molecules for the pathogenesis or the target molecules for the treatments of MS and NMO are also localized in lipid rafts. Here in this article, we highlight on the possible involvement of lipid rafts in the pathogenesis and treatment of MS and NMO and introduce our recent observation of aquaporin 4 regarding NMO.
UR - http://www.scopus.com/inward/record.url?scp=84919779759&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84919779759&partnerID=8YFLogxK
U2 - 10.2741/4310
DO - 10.2741/4310
M3 - Article
C2 - 25553452
AN - SCOPUS:84919779759
VL - 20
SP - 303
EP - 313
JO - Frontiers in Bioscience - Landmark
JF - Frontiers in Bioscience - Landmark
SN - 1093-9946
IS - 2
ER -