Lithium response and Val66Met polymorphism of the brain-derived neurotrophic factor gene in Japanese patients with bipolar disorder

Takuya Masui; Ryota Hashimoto; Ichiro Kusumi; Katsuji Suzuki; Teruaki Tanaka; Shin Nakagawa; Tatsuyo Suzuki; Nakao Iwata; Norio Ozaki; Tadafumi Kato; Hiroshi Kunugi; Tsukasa Koyama

doi:10.1097/01.ypg.0000180680.72922.57

Lithium response and Val66Met polymorphism of the brain-derived neurotrophic factor gene in Japanese patients with bipolar disorder

Takuya Masui, Ryota Hashimoto, Ichiro Kusumi, Katsuji Suzuki, Teruaki Tanaka, Shin Nakagawa, Tatsuyo Suzuki, Nakao Iwata, Norio Ozaki, Tadafumi Kato, Hiroshi Kunugi, Tsukasa Koyama

Psychiatry

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Abstract

Lithium is a first-line agent for the treatment of bipolar disorder. A significant association between the Val66Met polymorphism of the brain-derived neurotrophic factor gene and bipolar disorder has been reported. We investigated whether this polymorphism is associated with the response to lithium treatment in Japanese patients with bipolar disorder. Patients had been treated with lithium carbonate for more than 1 year, and the response was retrospectively evaluated. No significant differences were found in the genotype distribution or allele frequency between responders and non-responders. Our results suggested that the brain-derived neurotrophic factor Val66Met polymorphism might not greatly contribute to the efficacy of lithium in bipolar disorder.

Original language	English
Pages (from-to)	49-50
Number of pages	2
Journal	Psychiatric Genetics
Volume	16
Issue number	2
DOIs	https://doi.org/10.1097/01.ypg.0000180680.72922.57
Publication status	Published - 04-2006

All Science Journal Classification (ASJC) codes

Genetics
Genetics(clinical)
Psychiatry and Mental health
Biological Psychiatry

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10.1097/01.ypg.0000180680.72922.57

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Masui, T., Hashimoto, R., Kusumi, I., Suzuki, K., Tanaka, T., Nakagawa, S., Suzuki, T., Iwata, N., Ozaki, N., Kato, T., Kunugi, H., & Koyama, T. (2006). Lithium response and Val66Met polymorphism of the brain-derived neurotrophic factor gene in Japanese patients with bipolar disorder. Psychiatric Genetics, 16(2), 49-50. https://doi.org/10.1097/01.ypg.0000180680.72922.57

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title = "Lithium response and Val66Met polymorphism of the brain-derived neurotrophic factor gene in Japanese patients with bipolar disorder",

abstract = "Lithium is a first-line agent for the treatment of bipolar disorder. A significant association between the Val66Met polymorphism of the brain-derived neurotrophic factor gene and bipolar disorder has been reported. We investigated whether this polymorphism is associated with the response to lithium treatment in Japanese patients with bipolar disorder. Patients had been treated with lithium carbonate for more than 1 year, and the response was retrospectively evaluated. No significant differences were found in the genotype distribution or allele frequency between responders and non-responders. Our results suggested that the brain-derived neurotrophic factor Val66Met polymorphism might not greatly contribute to the efficacy of lithium in bipolar disorder.",

author = "Takuya Masui and Ryota Hashimoto and Ichiro Kusumi and Katsuji Suzuki and Teruaki Tanaka and Shin Nakagawa and Tatsuyo Suzuki and Nakao Iwata and Norio Ozaki and Tadafumi Kato and Hiroshi Kunugi and Tsukasa Koyama",

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Masui, T, Hashimoto, R, Kusumi, I, Suzuki, K, Tanaka, T, Nakagawa, S, Suzuki, T, Iwata, N, Ozaki, N, Kato, T, Kunugi, H & Koyama, T 2006, 'Lithium response and Val66Met polymorphism of the brain-derived neurotrophic factor gene in Japanese patients with bipolar disorder', Psychiatric Genetics, vol. 16, no. 2, pp. 49-50. https://doi.org/10.1097/01.ypg.0000180680.72922.57

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T1 - Lithium response and Val66Met polymorphism of the brain-derived neurotrophic factor gene in Japanese patients with bipolar disorder

AU - Masui, Takuya

AU - Hashimoto, Ryota

AU - Kusumi, Ichiro

AU - Suzuki, Katsuji

AU - Tanaka, Teruaki

AU - Nakagawa, Shin

AU - Suzuki, Tatsuyo

AU - Iwata, Nakao

AU - Ozaki, Norio

AU - Kato, Tadafumi

AU - Kunugi, Hiroshi

AU - Koyama, Tsukasa

PY - 2006/4

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N2 - Lithium is a first-line agent for the treatment of bipolar disorder. A significant association between the Val66Met polymorphism of the brain-derived neurotrophic factor gene and bipolar disorder has been reported. We investigated whether this polymorphism is associated with the response to lithium treatment in Japanese patients with bipolar disorder. Patients had been treated with lithium carbonate for more than 1 year, and the response was retrospectively evaluated. No significant differences were found in the genotype distribution or allele frequency between responders and non-responders. Our results suggested that the brain-derived neurotrophic factor Val66Met polymorphism might not greatly contribute to the efficacy of lithium in bipolar disorder.

AB - Lithium is a first-line agent for the treatment of bipolar disorder. A significant association between the Val66Met polymorphism of the brain-derived neurotrophic factor gene and bipolar disorder has been reported. We investigated whether this polymorphism is associated with the response to lithium treatment in Japanese patients with bipolar disorder. Patients had been treated with lithium carbonate for more than 1 year, and the response was retrospectively evaluated. No significant differences were found in the genotype distribution or allele frequency between responders and non-responders. Our results suggested that the brain-derived neurotrophic factor Val66Met polymorphism might not greatly contribute to the efficacy of lithium in bipolar disorder.

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Lithium response and Val66Met polymorphism of the brain-derived neurotrophic factor gene in Japanese patients with bipolar disorder

Abstract

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