Lithium response and Val66Met polymorphism of the brain-derived neurotrophic factor gene in Japanese patients with bipolar disorder

Takuya Masui, Ryota Hashimoto, Ichiro Kusumi, Katsuji Suzuki, Teruaki Tanaka, Shin Nakagawa, Tatsuyo Suzuki, Nakao Iwata, Norio Ozaki, Tadafumi Kato, Hiroshi Kunugi, Tsukasa Koyama

Research output: Contribution to journalArticle

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Abstract

Lithium is a first-line agent for the treatment of bipolar disorder. A significant association between the Val66Met polymorphism of the brain-derived neurotrophic factor gene and bipolar disorder has been reported. We investigated whether this polymorphism is associated with the response to lithium treatment in Japanese patients with bipolar disorder. Patients had been treated with lithium carbonate for more than 1 year, and the response was retrospectively evaluated. No significant differences were found in the genotype distribution or allele frequency between responders and non-responders. Our results suggested that the brain-derived neurotrophic factor Val66Met polymorphism might not greatly contribute to the efficacy of lithium in bipolar disorder.

Original languageEnglish
Pages (from-to)49-50
Number of pages2
JournalPsychiatric Genetics
Volume16
Issue number2
DOIs
Publication statusPublished - 01-04-2006

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Brain-Derived Neurotrophic Factor
Bipolar Disorder
Lithium
Genes
Lithium Carbonate
Gene Frequency
Genotype
Therapeutics

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)
  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Masui, Takuya ; Hashimoto, Ryota ; Kusumi, Ichiro ; Suzuki, Katsuji ; Tanaka, Teruaki ; Nakagawa, Shin ; Suzuki, Tatsuyo ; Iwata, Nakao ; Ozaki, Norio ; Kato, Tadafumi ; Kunugi, Hiroshi ; Koyama, Tsukasa. / Lithium response and Val66Met polymorphism of the brain-derived neurotrophic factor gene in Japanese patients with bipolar disorder. In: Psychiatric Genetics. 2006 ; Vol. 16, No. 2. pp. 49-50.
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Masui, T, Hashimoto, R, Kusumi, I, Suzuki, K, Tanaka, T, Nakagawa, S, Suzuki, T, Iwata, N, Ozaki, N, Kato, T, Kunugi, H & Koyama, T 2006, 'Lithium response and Val66Met polymorphism of the brain-derived neurotrophic factor gene in Japanese patients with bipolar disorder', Psychiatric Genetics, vol. 16, no. 2, pp. 49-50. https://doi.org/10.1097/01.ypg.0000180680.72922.57

Lithium response and Val66Met polymorphism of the brain-derived neurotrophic factor gene in Japanese patients with bipolar disorder. / Masui, Takuya; Hashimoto, Ryota; Kusumi, Ichiro; Suzuki, Katsuji; Tanaka, Teruaki; Nakagawa, Shin; Suzuki, Tatsuyo; Iwata, Nakao; Ozaki, Norio; Kato, Tadafumi; Kunugi, Hiroshi; Koyama, Tsukasa.

In: Psychiatric Genetics, Vol. 16, No. 2, 01.04.2006, p. 49-50.

Research output: Contribution to journalArticle

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AU - Masui, Takuya

AU - Hashimoto, Ryota

AU - Kusumi, Ichiro

AU - Suzuki, Katsuji

AU - Tanaka, Teruaki

AU - Nakagawa, Shin

AU - Suzuki, Tatsuyo

AU - Iwata, Nakao

AU - Ozaki, Norio

AU - Kato, Tadafumi

AU - Kunugi, Hiroshi

AU - Koyama, Tsukasa

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