Living donor pancreas transplantation in Japan

Takashi Kenmochi, Takehide Asano, Michihiro Maruyama, Kenichi Saigo, Naotake Akutsu, Chikara Iwashita, Kazunori Ohtsuki, Akiko Suzuki, Mariko Miyazaki

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background/purpose Living-donor pancreas transplants (LDPs) were introduced at Chiba-East National Hospital in 2004, and 12 LDPs have been performed at this institution to date. Based on the outcome of these 12 LDPs, the efficacy and safety of LDPs are herein discussed. Methods Twelve diabetic patients underwent LDPs; ten had simultaneous pancreas and kidney transplants from living donors, one had pancreas transplant after a kidney transplant from a living donor, and one had a pancreas transplant alone from a living donor. The donors were parents or brothers and the ABO blood types were incompatible in three LDPs. The procedures for the donor and recipient operations were performed according to the technique established by the University of Minnesota. Bladder drainage was used in 11 recipients and enteric drainage was used in one patient. Tacrolimus, basiliximab, mycophenolate mofetil, and prednisone were used for induction and immunosuppressive treatment. A splenectomy, double-filtered plasmapheresis, and plasma exchange were added in the ABO-incompatible LDPs. Results No complications were observed in the donors during hospitalization. The 1-year survivals of the patients, kidney grafts, and pancreas grafts were 100, 100, and 100%, respectively. The 3-year survivals were 91.7, 90, and 91.7%, respectively. Three patients developed leakage of pancreatic juice and one patient required a surgical procedure. Cytomegalovirus antigenemia was detected in five patients (42%). Conclusions Based on the excellent outcome of the LDPs at this institution, LDPs is therefore expected to become a promising option for the treatment of patients with severe diabetes.

Original languageEnglish
Pages (from-to)101-107
Number of pages7
JournalJournal of Hepato-Biliary-Pancreatic Sciences
Volume17
Issue number2
DOIs
Publication statusPublished - 01-03-2010
Externally publishedYes

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Pancreas Transplantation
Living Donors
Japan
Pancreas
Transplants
Tissue Donors
Kidney
Drainage
Mycophenolic Acid
Pancreatic Juice
Plasma Exchange
Plasmapheresis
Survival
Tacrolimus
Splenectomy
Immunosuppressive Agents
Prednisone
Cytomegalovirus

All Science Journal Classification (ASJC) codes

  • Surgery
  • Hepatology

Cite this

Kenmochi, T., Asano, T., Maruyama, M., Saigo, K., Akutsu, N., Iwashita, C., ... Miyazaki, M. (2010). Living donor pancreas transplantation in Japan. Journal of Hepato-Biliary-Pancreatic Sciences, 17(2), 101-107. https://doi.org/10.1007/s00534-009-0148-9
Kenmochi, Takashi ; Asano, Takehide ; Maruyama, Michihiro ; Saigo, Kenichi ; Akutsu, Naotake ; Iwashita, Chikara ; Ohtsuki, Kazunori ; Suzuki, Akiko ; Miyazaki, Mariko. / Living donor pancreas transplantation in Japan. In: Journal of Hepato-Biliary-Pancreatic Sciences. 2010 ; Vol. 17, No. 2. pp. 101-107.
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abstract = "Background/purpose Living-donor pancreas transplants (LDPs) were introduced at Chiba-East National Hospital in 2004, and 12 LDPs have been performed at this institution to date. Based on the outcome of these 12 LDPs, the efficacy and safety of LDPs are herein discussed. Methods Twelve diabetic patients underwent LDPs; ten had simultaneous pancreas and kidney transplants from living donors, one had pancreas transplant after a kidney transplant from a living donor, and one had a pancreas transplant alone from a living donor. The donors were parents or brothers and the ABO blood types were incompatible in three LDPs. The procedures for the donor and recipient operations were performed according to the technique established by the University of Minnesota. Bladder drainage was used in 11 recipients and enteric drainage was used in one patient. Tacrolimus, basiliximab, mycophenolate mofetil, and prednisone were used for induction and immunosuppressive treatment. A splenectomy, double-filtered plasmapheresis, and plasma exchange were added in the ABO-incompatible LDPs. Results No complications were observed in the donors during hospitalization. The 1-year survivals of the patients, kidney grafts, and pancreas grafts were 100, 100, and 100{\%}, respectively. The 3-year survivals were 91.7, 90, and 91.7{\%}, respectively. Three patients developed leakage of pancreatic juice and one patient required a surgical procedure. Cytomegalovirus antigenemia was detected in five patients (42{\%}). Conclusions Based on the excellent outcome of the LDPs at this institution, LDPs is therefore expected to become a promising option for the treatment of patients with severe diabetes.",
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Kenmochi, T, Asano, T, Maruyama, M, Saigo, K, Akutsu, N, Iwashita, C, Ohtsuki, K, Suzuki, A & Miyazaki, M 2010, 'Living donor pancreas transplantation in Japan', Journal of Hepato-Biliary-Pancreatic Sciences, vol. 17, no. 2, pp. 101-107. https://doi.org/10.1007/s00534-009-0148-9

Living donor pancreas transplantation in Japan. / Kenmochi, Takashi; Asano, Takehide; Maruyama, Michihiro; Saigo, Kenichi; Akutsu, Naotake; Iwashita, Chikara; Ohtsuki, Kazunori; Suzuki, Akiko; Miyazaki, Mariko.

In: Journal of Hepato-Biliary-Pancreatic Sciences, Vol. 17, No. 2, 01.03.2010, p. 101-107.

Research output: Contribution to journalArticle

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T1 - Living donor pancreas transplantation in Japan

AU - Kenmochi, Takashi

AU - Asano, Takehide

AU - Maruyama, Michihiro

AU - Saigo, Kenichi

AU - Akutsu, Naotake

AU - Iwashita, Chikara

AU - Ohtsuki, Kazunori

AU - Suzuki, Akiko

AU - Miyazaki, Mariko

PY - 2010/3/1

Y1 - 2010/3/1

N2 - Background/purpose Living-donor pancreas transplants (LDPs) were introduced at Chiba-East National Hospital in 2004, and 12 LDPs have been performed at this institution to date. Based on the outcome of these 12 LDPs, the efficacy and safety of LDPs are herein discussed. Methods Twelve diabetic patients underwent LDPs; ten had simultaneous pancreas and kidney transplants from living donors, one had pancreas transplant after a kidney transplant from a living donor, and one had a pancreas transplant alone from a living donor. The donors were parents or brothers and the ABO blood types were incompatible in three LDPs. The procedures for the donor and recipient operations were performed according to the technique established by the University of Minnesota. Bladder drainage was used in 11 recipients and enteric drainage was used in one patient. Tacrolimus, basiliximab, mycophenolate mofetil, and prednisone were used for induction and immunosuppressive treatment. A splenectomy, double-filtered plasmapheresis, and plasma exchange were added in the ABO-incompatible LDPs. Results No complications were observed in the donors during hospitalization. The 1-year survivals of the patients, kidney grafts, and pancreas grafts were 100, 100, and 100%, respectively. The 3-year survivals were 91.7, 90, and 91.7%, respectively. Three patients developed leakage of pancreatic juice and one patient required a surgical procedure. Cytomegalovirus antigenemia was detected in five patients (42%). Conclusions Based on the excellent outcome of the LDPs at this institution, LDPs is therefore expected to become a promising option for the treatment of patients with severe diabetes.

AB - Background/purpose Living-donor pancreas transplants (LDPs) were introduced at Chiba-East National Hospital in 2004, and 12 LDPs have been performed at this institution to date. Based on the outcome of these 12 LDPs, the efficacy and safety of LDPs are herein discussed. Methods Twelve diabetic patients underwent LDPs; ten had simultaneous pancreas and kidney transplants from living donors, one had pancreas transplant after a kidney transplant from a living donor, and one had a pancreas transplant alone from a living donor. The donors were parents or brothers and the ABO blood types were incompatible in three LDPs. The procedures for the donor and recipient operations were performed according to the technique established by the University of Minnesota. Bladder drainage was used in 11 recipients and enteric drainage was used in one patient. Tacrolimus, basiliximab, mycophenolate mofetil, and prednisone were used for induction and immunosuppressive treatment. A splenectomy, double-filtered plasmapheresis, and plasma exchange were added in the ABO-incompatible LDPs. Results No complications were observed in the donors during hospitalization. The 1-year survivals of the patients, kidney grafts, and pancreas grafts were 100, 100, and 100%, respectively. The 3-year survivals were 91.7, 90, and 91.7%, respectively. Three patients developed leakage of pancreatic juice and one patient required a surgical procedure. Cytomegalovirus antigenemia was detected in five patients (42%). Conclusions Based on the excellent outcome of the LDPs at this institution, LDPs is therefore expected to become a promising option for the treatment of patients with severe diabetes.

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