Local leukocyte proliferation as a target for cyclophosphamide in the treatment of Henoch-Schönlein purpura nephritis grade VI

Masahiro Kaneko, Yohei Ikezumi, Takeshi Yamada, Hiroya Hasegawa, Utako Kaneko, Akihiko Saitoh

Research output: Contribution to journalArticle

Abstract

Henoch-Schönlein purpura nephritis (HSPN) is one of the most common types of chronic glomerulonephritis in children; however, there have been few reports on the pathogenesis and management of grade VI HSPN. We present the case of a 6-year-old boy with grade VI HSPN accompanied by severe nephrotic syndrome and hypocomplementaemia. Immunohistological studies revealed profound glomerular accumulation of CD45- and CD68-positive inflammatory cells. Moreover, some cells expressed the proliferating marker proliferating cell nuclear antigen. His proteinuria and general oedema persisted despite repeated high-dose steroid therapy; however, these clinical symptoms immediately improved after beginning treatment with cyclophosphamide (CYP). Grade VI HSPN was successfully treated with steroids and immunosuppressants. Among immunosuppressive drugs, CYP was considered the most effective.

Original languageEnglish
Pages (from-to)68-71
Number of pages4
JournalNephrology
Volume21
Issue number1
DOIs
Publication statusPublished - 01-01-2016

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Schoenlein-Henoch Purpura
Nephritis
Cyclophosphamide
Leukocytes
Immunosuppressive Agents
Steroids
Proliferating Cell Nuclear Antigen
Nephrotic Syndrome
Therapeutics
Glomerulonephritis
Proteinuria
Edema
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Nephrology

Cite this

Kaneko, Masahiro ; Ikezumi, Yohei ; Yamada, Takeshi ; Hasegawa, Hiroya ; Kaneko, Utako ; Saitoh, Akihiko. / Local leukocyte proliferation as a target for cyclophosphamide in the treatment of Henoch-Schönlein purpura nephritis grade VI. In: Nephrology. 2016 ; Vol. 21, No. 1. pp. 68-71.
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Local leukocyte proliferation as a target for cyclophosphamide in the treatment of Henoch-Schönlein purpura nephritis grade VI. / Kaneko, Masahiro; Ikezumi, Yohei; Yamada, Takeshi; Hasegawa, Hiroya; Kaneko, Utako; Saitoh, Akihiko.

In: Nephrology, Vol. 21, No. 1, 01.01.2016, p. 68-71.

Research output: Contribution to journalArticle

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T1 - Local leukocyte proliferation as a target for cyclophosphamide in the treatment of Henoch-Schönlein purpura nephritis grade VI

AU - Kaneko, Masahiro

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AU - Kaneko, Utako

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AB - Henoch-Schönlein purpura nephritis (HSPN) is one of the most common types of chronic glomerulonephritis in children; however, there have been few reports on the pathogenesis and management of grade VI HSPN. We present the case of a 6-year-old boy with grade VI HSPN accompanied by severe nephrotic syndrome and hypocomplementaemia. Immunohistological studies revealed profound glomerular accumulation of CD45- and CD68-positive inflammatory cells. Moreover, some cells expressed the proliferating marker proliferating cell nuclear antigen. His proteinuria and general oedema persisted despite repeated high-dose steroid therapy; however, these clinical symptoms immediately improved after beginning treatment with cyclophosphamide (CYP). Grade VI HSPN was successfully treated with steroids and immunosuppressants. Among immunosuppressive drugs, CYP was considered the most effective.

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