Localization of Fas antigen mRNA induced in postischemic murine forebrain by in situ hybridization

Tomohiro Matsuyama; Ryuji Hata; Yoshihiro Yamamoto; Masafumi Tagaya; Hiroshi Akita; Hisakazu Uno; Akio Wanaka; Jun ichi Furuyama; Minoru Sugita

doi:10.1016/0169-328X(95)00162-L

Localization of Fas antigen mRNA induced in postischemic murine forebrain by in situ hybridization

Tomohiro Matsuyama, Ryuji Hata, Yoshihiro Yamamoto, Masafumi Tagaya, Hiroshi Akita, Hisakazu Uno, Akio Wanaka, Jun ichi Furuyama, Minoru Sugita

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Abstract

The expression of mRNA for the Fas antigen, a membrane-associated protein mediating apoptosis, was localized by in situ hybridization histochemistry in murine brains following 30 min of global cerebral ischemia. Six hours following the ischemia, many labeled cells were detected anew throughout the brain. The hybridization was seen in the small neural cells and in the cells along the walls of the ventricles and vessels, and became undetectable 24 h following the ischemia. These results suggest that the Fas antigen is expressed in the neuron, glia and periventricular cells of the post-ischemic brain.

Original language	English
Pages (from-to)	166-172
Number of pages	7
Journal	Molecular Brain Research
Volume	34
Issue number	1
DOIs	https://doi.org/10.1016/0169-328X(95)00162-L
Publication status	Published - 01-12-1995
Externally published	Yes

All Science Journal Classification (ASJC) codes

Molecular Biology
Cellular and Molecular Neuroscience

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10.1016/0169-328X(95)00162-L

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title = "Localization of Fas antigen mRNA induced in postischemic murine forebrain by in situ hybridization",

abstract = "The expression of mRNA for the Fas antigen, a membrane-associated protein mediating apoptosis, was localized by in situ hybridization histochemistry in murine brains following 30 min of global cerebral ischemia. Six hours following the ischemia, many labeled cells were detected anew throughout the brain. The hybridization was seen in the small neural cells and in the cells along the walls of the ventricles and vessels, and became undetectable 24 h following the ischemia. These results suggest that the Fas antigen is expressed in the neuron, glia and periventricular cells of the post-ischemic brain.",

author = "Tomohiro Matsuyama and Ryuji Hata and Yoshihiro Yamamoto and Masafumi Tagaya and Hiroshi Akita and Hisakazu Uno and Akio Wanaka and Furuyama, {Jun ichi} and Minoru Sugita",

note = "Funding Information: This work was supported in part by Grants-in-Aid for Scientific Research by the Ministry of Education, Science and Culture, Japan.",

year = "1995",

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doi = "10.1016/0169-328X(95)00162-L",

language = "English",

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TY - JOUR

T1 - Localization of Fas antigen mRNA induced in postischemic murine forebrain by in situ hybridization

AU - Matsuyama, Tomohiro

AU - Hata, Ryuji

AU - Yamamoto, Yoshihiro

AU - Tagaya, Masafumi

AU - Akita, Hiroshi

AU - Uno, Hisakazu

AU - Wanaka, Akio

AU - Furuyama, Jun ichi

AU - Sugita, Minoru

N1 - Funding Information: This work was supported in part by Grants-in-Aid for Scientific Research by the Ministry of Education, Science and Culture, Japan.

PY - 1995/12/1

Y1 - 1995/12/1

N2 - The expression of mRNA for the Fas antigen, a membrane-associated protein mediating apoptosis, was localized by in situ hybridization histochemistry in murine brains following 30 min of global cerebral ischemia. Six hours following the ischemia, many labeled cells were detected anew throughout the brain. The hybridization was seen in the small neural cells and in the cells along the walls of the ventricles and vessels, and became undetectable 24 h following the ischemia. These results suggest that the Fas antigen is expressed in the neuron, glia and periventricular cells of the post-ischemic brain.

AB - The expression of mRNA for the Fas antigen, a membrane-associated protein mediating apoptosis, was localized by in situ hybridization histochemistry in murine brains following 30 min of global cerebral ischemia. Six hours following the ischemia, many labeled cells were detected anew throughout the brain. The hybridization was seen in the small neural cells and in the cells along the walls of the ventricles and vessels, and became undetectable 24 h following the ischemia. These results suggest that the Fas antigen is expressed in the neuron, glia and periventricular cells of the post-ischemic brain.

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DO - 10.1016/0169-328X(95)00162-L

M3 - Article

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AN - SCOPUS:0028820861

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EP - 172

JO - Molecular Brain Research

JF - Molecular Brain Research

IS - 1

ER -

Localization of Fas antigen mRNA induced in postischemic murine forebrain by in situ hybridization

Abstract

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