Localization of Fas antigen mRNA induced in postischemic murine forebrain by in situ hybridization

Tomohiro Matsuyama, Ryuji Hata, Yoshihiro Yamamoto, Masafumi Tagaya, Hiroshi Akita, Hisakazu Uno, Akio Wanaka, Jun ichi Furuyama, Minoru Sugita

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

The expression of mRNA for the Fas antigen, a membrane-associated protein mediating apoptosis, was localized by in situ hybridization histochemistry in murine brains following 30 min of global cerebral ischemia. Six hours following the ischemia, many labeled cells were detected anew throughout the brain. The hybridization was seen in the small neural cells and in the cells along the walls of the ventricles and vessels, and became undetectable 24 h following the ischemia. These results suggest that the Fas antigen is expressed in the neuron, glia and periventricular cells of the post-ischemic brain.

Original languageEnglish
Pages (from-to)166-172
Number of pages7
JournalMolecular Brain Research
Volume34
Issue number1
DOIs
Publication statusPublished - 01-12-1995

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CD95 Antigens
Prosencephalon
In Situ Hybridization
Messenger RNA
Brain
Ischemia
Brain Ischemia
Neuroglia
Cell Wall
Membrane Proteins
Apoptosis
Neurons

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cellular and Molecular Neuroscience

Cite this

Matsuyama, Tomohiro ; Hata, Ryuji ; Yamamoto, Yoshihiro ; Tagaya, Masafumi ; Akita, Hiroshi ; Uno, Hisakazu ; Wanaka, Akio ; Furuyama, Jun ichi ; Sugita, Minoru. / Localization of Fas antigen mRNA induced in postischemic murine forebrain by in situ hybridization. In: Molecular Brain Research. 1995 ; Vol. 34, No. 1. pp. 166-172.
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abstract = "The expression of mRNA for the Fas antigen, a membrane-associated protein mediating apoptosis, was localized by in situ hybridization histochemistry in murine brains following 30 min of global cerebral ischemia. Six hours following the ischemia, many labeled cells were detected anew throughout the brain. The hybridization was seen in the small neural cells and in the cells along the walls of the ventricles and vessels, and became undetectable 24 h following the ischemia. These results suggest that the Fas antigen is expressed in the neuron, glia and periventricular cells of the post-ischemic brain.",
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Matsuyama, T, Hata, R, Yamamoto, Y, Tagaya, M, Akita, H, Uno, H, Wanaka, A, Furuyama, JI & Sugita, M 1995, 'Localization of Fas antigen mRNA induced in postischemic murine forebrain by in situ hybridization', Molecular Brain Research, vol. 34, no. 1, pp. 166-172. https://doi.org/10.1016/0169-328X(95)00162-L

Localization of Fas antigen mRNA induced in postischemic murine forebrain by in situ hybridization. / Matsuyama, Tomohiro; Hata, Ryuji; Yamamoto, Yoshihiro; Tagaya, Masafumi; Akita, Hiroshi; Uno, Hisakazu; Wanaka, Akio; Furuyama, Jun ichi; Sugita, Minoru.

In: Molecular Brain Research, Vol. 34, No. 1, 01.12.1995, p. 166-172.

Research output: Contribution to journalArticle

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AB - The expression of mRNA for the Fas antigen, a membrane-associated protein mediating apoptosis, was localized by in situ hybridization histochemistry in murine brains following 30 min of global cerebral ischemia. Six hours following the ischemia, many labeled cells were detected anew throughout the brain. The hybridization was seen in the small neural cells and in the cells along the walls of the ventricles and vessels, and became undetectable 24 h following the ischemia. These results suggest that the Fas antigen is expressed in the neuron, glia and periventricular cells of the post-ischemic brain.

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