Localization of the 31-amino-acid endothelin-1 in hamster tissue

Sae Kakui, Kazuaki Mawatari, Takamasa Ohnishi, Yasuharu Niwa, Naomi Tanoue, Nagakatsu Harada, Akira Takahashi, Keisuke Izume, Yutaka Nakaya

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Endothelin (ET)-1(1-31) is a novel vasoconstrictor peptide produced by human mast cell chymase, which selectively cleaves big ET-1 at the Try 31-Gly32 bond. We investigated the localization of ET-1(1-31) in various hamster tissues by immunohistochemistry and compared it to the distribution of ET-1(1-21). We found that the localization and amount of ET-1(1-31) were different from those of ET-1(1-21) in each tissue. ET-1(1-31)-like immunoreactivities (IR) in the heart, lung, and adrenal gland were observed in the same areas as ET-1(1-21) but were significantly weaker, suggesting that ET-1(1-31) might play a role only in mast cell/chymase-related pathological conditions in these tissues. In the liver, ET-1(1-31)-like IR was strongly detected in Kupffer cells where ET-1(1-21)-like IR was seen more weakly. In the kidney, ET-1(1-31)-like IR was slightly higher than ET-1(1-21). These results suggest that ET-1(1-31) might have physiological roles distinct from those of ET-1(1-21) in some hamster tissues.

Original languageEnglish
Pages (from-to)1435-1443
Number of pages9
JournalLife Sciences
Issue number11
Publication statusPublished - 30-01-2004

All Science Journal Classification (ASJC) codes

  • General Pharmacology, Toxicology and Pharmaceutics
  • General Biochemistry,Genetics and Molecular Biology


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