Localization of the gene coding for myosin phosphatase, target subunit 1 (MYPT1) to human chromosome 12q15-q21

N. Takahashi, M. Ito, J. Tanaka, T. Nakano, K. Kaibuchi, H. Odai, K. Takemura

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47 Citations (Scopus)


Myosin phosphatase target subunit 1 (MYPT1), which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the inter-action of actin and myosin downstream of the guanosine triphosphatase Rho, as previously shown (K. Kimura, et aL, 1996, Science 273: 245-248). To understand the role of MYPT1 in the regulation of the cytoskeleton in human diseases, we have cloned a 4855-bp cDNA for human MYPT1 using the rat MYPT1 cDNA as probe. Sequencing analysis has revealed that human MYPT1 contains 1030 amino acid residues with a calculated molecular mass of approximately 115 kDa. Fluorescence in situ hybridization analysis placed the human MYPT1 gene on chromosome 12q15-q21.2. Radiation hybrid mapping has shown that the human MYPT1 gene is located very near the highly polymorphic marker CHLC.GATA65A12, which lies between D12S350 and D12S106.

Original languageEnglish
Pages (from-to)150-152
Number of pages3
Issue number1
Publication statusPublished - 15-08-1997
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Genetics


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