Localization of the gene coding for ROCK II/Rho kinase on human chromosome 2p24

N. Takahashi; H. Tuiki; H. Saya; K. Kaibuchi

doi:10.1006/geno.1998.5344

Localization of the gene coding for ROCK II/Rho kinase on human chromosome 2p24

N. Takahashi, H. Tuiki, H. Saya, K. Kaibuchi

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Serine/threonine kinase ROCK II/Rho kinase, which is an isozyme of ROCK I, is one of the targets for the small GTPase Rho. ROCK II regulates the formation of actin stress fibers and focal adhesions, cytokinesis, smooth muscle contraction, and the activation of c-fos serum response element. To elucidate the role of ROCK II in human disease, we have cloned a 4363-bp cDNA encoding human ROCK II. Sequencing analysis has shown that human ROCK II contains 1388 amino acid residues with a calculated molecular mass of approximately 161 kDa. Fluorescence in situ hybridization analysis showed that the human ROCK II gene is located on chromosome 2p24. Radiation hybrid mapping has shown that the human ROCK II gene is located very close to the highly polymorphic marker D2S359.

Original language	English
Pages (from-to)	235-237
Number of pages	3
Journal	Genomics
Volume	55
Issue number	2
DOIs	https://doi.org/10.1006/geno.1998.5344
Publication status	Published - 15-01-1999
Externally published	Yes

All Science Journal Classification (ASJC) codes

Genetics

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1006/geno.1998.5344

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title = "Localization of the gene coding for ROCK II/Rho kinase on human chromosome 2p24",

abstract = "Serine/threonine kinase ROCK II/Rho kinase, which is an isozyme of ROCK I, is one of the targets for the small GTPase Rho. ROCK II regulates the formation of actin stress fibers and focal adhesions, cytokinesis, smooth muscle contraction, and the activation of c-fos serum response element. To elucidate the role of ROCK II in human disease, we have cloned a 4363-bp cDNA encoding human ROCK II. Sequencing analysis has shown that human ROCK II contains 1388 amino acid residues with a calculated molecular mass of approximately 161 kDa. Fluorescence in situ hybridization analysis showed that the human ROCK II gene is located on chromosome 2p24. Radiation hybrid mapping has shown that the human ROCK II gene is located very close to the highly polymorphic marker D2S359.",

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AU - Takahashi, N.

AU - Tuiki, H.

AU - Saya, H.

AU - Kaibuchi, K.

PY - 1999/1/15

Y1 - 1999/1/15

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AB - Serine/threonine kinase ROCK II/Rho kinase, which is an isozyme of ROCK I, is one of the targets for the small GTPase Rho. ROCK II regulates the formation of actin stress fibers and focal adhesions, cytokinesis, smooth muscle contraction, and the activation of c-fos serum response element. To elucidate the role of ROCK II in human disease, we have cloned a 4363-bp cDNA encoding human ROCK II. Sequencing analysis has shown that human ROCK II contains 1388 amino acid residues with a calculated molecular mass of approximately 161 kDa. Fluorescence in situ hybridization analysis showed that the human ROCK II gene is located on chromosome 2p24. Radiation hybrid mapping has shown that the human ROCK II gene is located very close to the highly polymorphic marker D2S359.

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Localization of the gene coding for ROCK II/Rho kinase on human chromosome 2p24

Abstract

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