TY - JOUR
T1 - Localized astrogenesis regulates gyrification of the cerebral cortex
AU - Shinmyo, Yohei
AU - Saito, Kengo
AU - Hamabe-Horiike, Toshihide
AU - Kameya, Narufumi
AU - Ando, Akitaka
AU - Kawasaki, Kanji
AU - Duong, Tung Anh Dinh
AU - Sakashita, Masataka
AU - Roboon, Jureepon
AU - Hattori, Tsuyoshi
AU - Kannon, Takayuki
AU - Hosomichi, Kazuyoshi
AU - Slezak, Michal
AU - Holt, Matthew G.
AU - Tajima, Atsushi
AU - Hori, Osamu
AU - Kawasaki, Hiroshi
N1 - Publisher Copyright:
Copyright © 2022 The Authors,
PY - 2022/3
Y1 - 2022/3
N2 - The development and evolution of mammalian higher cognition are represented by gyrification of the laminar cerebral cortex and astrocyte development, but their mechanisms and interrelationships remain unknown. Here, we show that localized astrogenesis plays an important role in gyri formation in the gyrencephalic cerebral cortex. In functional genetic experiments, we show that reducing astrocyte number prevents gyri formation in the ferret cortex, while increasing astrocyte number in mice, which do not have cortical folds, can induce gyrus-like protrusions. Morphometric analyses demonstrate that the vertical expansion of deep pallial regions achieved by localized astrogenesis is crucial for gyri formation. Furthermore, our findings suggest that localized astrogenesis by a positive feedback loop of FGF signaling is an important mechanism underlying cortical folding in gyrencephalic mammalian brains. Our findings reveal both the cellular mechanisms and the mechanical principle of gyrification in the mammalian brain.
AB - The development and evolution of mammalian higher cognition are represented by gyrification of the laminar cerebral cortex and astrocyte development, but their mechanisms and interrelationships remain unknown. Here, we show that localized astrogenesis plays an important role in gyri formation in the gyrencephalic cerebral cortex. In functional genetic experiments, we show that reducing astrocyte number prevents gyri formation in the ferret cortex, while increasing astrocyte number in mice, which do not have cortical folds, can induce gyrus-like protrusions. Morphometric analyses demonstrate that the vertical expansion of deep pallial regions achieved by localized astrogenesis is crucial for gyri formation. Furthermore, our findings suggest that localized astrogenesis by a positive feedback loop of FGF signaling is an important mechanism underlying cortical folding in gyrencephalic mammalian brains. Our findings reveal both the cellular mechanisms and the mechanical principle of gyrification in the mammalian brain.
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U2 - 10.1126/sciadv.abi5209
DO - 10.1126/sciadv.abi5209
M3 - Article
C2 - 35275722
AN - SCOPUS:85126388716
SN - 2375-2548
VL - 8
JO - Science advances
JF - Science advances
IS - 10
M1 - eabi5209
ER -