Long noncoding RNA #32 contributes to antiviral responses by controlling interferon-stimulated gene expression

Hironori Nishitsuji, Saneyuki Ujino, Sachiyo Yoshio, Masaya Sugiyama, Masashi Mizokami, Tatsuya Kanto, Kunitada Shimotohno

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Despite the breadth of knowledge that exists regarding the function of long noncoding RNAs (lncRNAs) in biological phenomena, the role of lncRNAs in host antiviral responses is poorly understood. Here, we report that lncRNA#32 is associated with type I IFN signaling. The silencing of lncRNA#32 dramatically reduced the level of IFN-stimulated gene (ISG) expression, resulting in sensitivity to encephalomyocarditis virus (EMCV) infection. In contrast, the ectopic expression of lncRNA#32 significantly suppressed EMCV replication, suggesting that lncRNA#32 positively regulates the host antiviral response. We further demonstrated the suppressive function of lncRNA#32 in hepatitis B virus and hepatitis C virus infection. lncRNA#32 bound to activating transcription factor 2 (ATF2) and regulated ISG expression. Our results reveal a role for lncRNA#32 in host antiviral responses.

Original languageEnglish
Pages (from-to)10388-10393
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume113
Issue number37
DOIs
Publication statusPublished - 13-09-2016

All Science Journal Classification (ASJC) codes

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