Long-term body weight variability is associated with elevated C-reactive protein independent of current body mass index among Japanese men

K. Tamakoshi, Hiroshi Yatsuya, T. Kondo, M. Ishikawa, H. Zhang, C. Murata, R. Otsuka, T. Mabuchi, Y. Hori, S. Zhu, T. Yoshida, H. Toyoshima

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

OBJECTIVE: To elucidate the effect of long-term weight variability on C-reactive protein (CRP) levels. DESIGN: Cross-sectional study of the circulating CRP. SUBJECTS: A total of 637 Japanese men aged 40-49y in 1997. MEASUREMENTS: Serum CRP levels, body mass index in 1997 (current BMI), the slope of weight on age (weight-slope) representing an individual's weight trend of direction and magnitude, and the root mean square error around the slope of weight on age (weight-RMSE) representing the weight fluctuation magnitude, as calculated by a simple linear regression model in which each value of the subject s five actual weights (aged 20, 25, 30y, five years ago, and current) was a dependent variable and the subject's ages independent variables. RESULTS: After adjustment for age and confounders, including smoking and health status, the odds ratios of elevated CRP (≥0.06 mg/dl) were 1.83 (95% CI: 1.25-2.69), 2.63 (1.69-4.11), and 10.31 (2.17-48.98) for upper normal-weight (BMI: 22-<25 kg/m2), overweight (25-<30), and obese (≥30) persons, respectively, compared with lower normal-weight persons (18.5-<22). Adjusting for age, confounders, and current BMI, weight-slope was positively associated with CRP level especially among subjects with BMI≥25 kg/m 2 (trend P<0.01), and weight-RMSE was positively associated with CRP level particularly among subjects with BMI <25 kg/m2 (trend P<0.05). CONCLUSION: Our results suggest a state of low-grade systemic inflammation not only in overweight and obese persons, but also in normal-weight persons with large weight fluctuation, possibly explaining in part the positive association between weight fluctuation and CVD.

Original languageEnglish
Pages (from-to)1059-1065
Number of pages7
JournalInternational Journal of Obesity
Volume27
Issue number9
DOIs
Publication statusPublished - 01-09-2003

Fingerprint

C-reactive protein
C-Reactive Protein
body mass index
Body Mass Index
Body Weight
Weights and Measures
body weight
Linear Models
health status
cross-sectional studies
odds ratio
Health Status
blood proteins
long term effects
Blood Proteins

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Public Health, Environmental and Occupational Health
  • Endocrinology
  • Food Science
  • Endocrinology, Diabetes and Metabolism

Cite this

Tamakoshi, K. ; Yatsuya, Hiroshi ; Kondo, T. ; Ishikawa, M. ; Zhang, H. ; Murata, C. ; Otsuka, R. ; Mabuchi, T. ; Hori, Y. ; Zhu, S. ; Yoshida, T. ; Toyoshima, H. / Long-term body weight variability is associated with elevated C-reactive protein independent of current body mass index among Japanese men. In: International Journal of Obesity. 2003 ; Vol. 27, No. 9. pp. 1059-1065.
@article{3e4ea81aa00c4792a545bc730cf9f056,
title = "Long-term body weight variability is associated with elevated C-reactive protein independent of current body mass index among Japanese men",
abstract = "OBJECTIVE: To elucidate the effect of long-term weight variability on C-reactive protein (CRP) levels. DESIGN: Cross-sectional study of the circulating CRP. SUBJECTS: A total of 637 Japanese men aged 40-49y in 1997. MEASUREMENTS: Serum CRP levels, body mass index in 1997 (current BMI), the slope of weight on age (weight-slope) representing an individual's weight trend of direction and magnitude, and the root mean square error around the slope of weight on age (weight-RMSE) representing the weight fluctuation magnitude, as calculated by a simple linear regression model in which each value of the subject s five actual weights (aged 20, 25, 30y, five years ago, and current) was a dependent variable and the subject's ages independent variables. RESULTS: After adjustment for age and confounders, including smoking and health status, the odds ratios of elevated CRP (≥0.06 mg/dl) were 1.83 (95{\%} CI: 1.25-2.69), 2.63 (1.69-4.11), and 10.31 (2.17-48.98) for upper normal-weight (BMI: 22-<25 kg/m2), overweight (25-<30), and obese (≥30) persons, respectively, compared with lower normal-weight persons (18.5-<22). Adjusting for age, confounders, and current BMI, weight-slope was positively associated with CRP level especially among subjects with BMI≥25 kg/m 2 (trend P<0.01), and weight-RMSE was positively associated with CRP level particularly among subjects with BMI <25 kg/m2 (trend P<0.05). CONCLUSION: Our results suggest a state of low-grade systemic inflammation not only in overweight and obese persons, but also in normal-weight persons with large weight fluctuation, possibly explaining in part the positive association between weight fluctuation and CVD.",
author = "K. Tamakoshi and Hiroshi Yatsuya and T. Kondo and M. Ishikawa and H. Zhang and C. Murata and R. Otsuka and T. Mabuchi and Y. Hori and S. Zhu and T. Yoshida and H. Toyoshima",
year = "2003",
month = "9",
day = "1",
doi = "10.1038/sj.ijo.0802386",
language = "English",
volume = "27",
pages = "1059--1065",
journal = "International Journal of Obesity",
issn = "0307-0565",
publisher = "Nature Publishing Group",
number = "9",

}

Tamakoshi, K, Yatsuya, H, Kondo, T, Ishikawa, M, Zhang, H, Murata, C, Otsuka, R, Mabuchi, T, Hori, Y, Zhu, S, Yoshida, T & Toyoshima, H 2003, 'Long-term body weight variability is associated with elevated C-reactive protein independent of current body mass index among Japanese men', International Journal of Obesity, vol. 27, no. 9, pp. 1059-1065. https://doi.org/10.1038/sj.ijo.0802386

Long-term body weight variability is associated with elevated C-reactive protein independent of current body mass index among Japanese men. / Tamakoshi, K.; Yatsuya, Hiroshi; Kondo, T.; Ishikawa, M.; Zhang, H.; Murata, C.; Otsuka, R.; Mabuchi, T.; Hori, Y.; Zhu, S.; Yoshida, T.; Toyoshima, H.

In: International Journal of Obesity, Vol. 27, No. 9, 01.09.2003, p. 1059-1065.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Long-term body weight variability is associated with elevated C-reactive protein independent of current body mass index among Japanese men

AU - Tamakoshi, K.

AU - Yatsuya, Hiroshi

AU - Kondo, T.

AU - Ishikawa, M.

AU - Zhang, H.

AU - Murata, C.

AU - Otsuka, R.

AU - Mabuchi, T.

AU - Hori, Y.

AU - Zhu, S.

AU - Yoshida, T.

AU - Toyoshima, H.

PY - 2003/9/1

Y1 - 2003/9/1

N2 - OBJECTIVE: To elucidate the effect of long-term weight variability on C-reactive protein (CRP) levels. DESIGN: Cross-sectional study of the circulating CRP. SUBJECTS: A total of 637 Japanese men aged 40-49y in 1997. MEASUREMENTS: Serum CRP levels, body mass index in 1997 (current BMI), the slope of weight on age (weight-slope) representing an individual's weight trend of direction and magnitude, and the root mean square error around the slope of weight on age (weight-RMSE) representing the weight fluctuation magnitude, as calculated by a simple linear regression model in which each value of the subject s five actual weights (aged 20, 25, 30y, five years ago, and current) was a dependent variable and the subject's ages independent variables. RESULTS: After adjustment for age and confounders, including smoking and health status, the odds ratios of elevated CRP (≥0.06 mg/dl) were 1.83 (95% CI: 1.25-2.69), 2.63 (1.69-4.11), and 10.31 (2.17-48.98) for upper normal-weight (BMI: 22-<25 kg/m2), overweight (25-<30), and obese (≥30) persons, respectively, compared with lower normal-weight persons (18.5-<22). Adjusting for age, confounders, and current BMI, weight-slope was positively associated with CRP level especially among subjects with BMI≥25 kg/m 2 (trend P<0.01), and weight-RMSE was positively associated with CRP level particularly among subjects with BMI <25 kg/m2 (trend P<0.05). CONCLUSION: Our results suggest a state of low-grade systemic inflammation not only in overweight and obese persons, but also in normal-weight persons with large weight fluctuation, possibly explaining in part the positive association between weight fluctuation and CVD.

AB - OBJECTIVE: To elucidate the effect of long-term weight variability on C-reactive protein (CRP) levels. DESIGN: Cross-sectional study of the circulating CRP. SUBJECTS: A total of 637 Japanese men aged 40-49y in 1997. MEASUREMENTS: Serum CRP levels, body mass index in 1997 (current BMI), the slope of weight on age (weight-slope) representing an individual's weight trend of direction and magnitude, and the root mean square error around the slope of weight on age (weight-RMSE) representing the weight fluctuation magnitude, as calculated by a simple linear regression model in which each value of the subject s five actual weights (aged 20, 25, 30y, five years ago, and current) was a dependent variable and the subject's ages independent variables. RESULTS: After adjustment for age and confounders, including smoking and health status, the odds ratios of elevated CRP (≥0.06 mg/dl) were 1.83 (95% CI: 1.25-2.69), 2.63 (1.69-4.11), and 10.31 (2.17-48.98) for upper normal-weight (BMI: 22-<25 kg/m2), overweight (25-<30), and obese (≥30) persons, respectively, compared with lower normal-weight persons (18.5-<22). Adjusting for age, confounders, and current BMI, weight-slope was positively associated with CRP level especially among subjects with BMI≥25 kg/m 2 (trend P<0.01), and weight-RMSE was positively associated with CRP level particularly among subjects with BMI <25 kg/m2 (trend P<0.05). CONCLUSION: Our results suggest a state of low-grade systemic inflammation not only in overweight and obese persons, but also in normal-weight persons with large weight fluctuation, possibly explaining in part the positive association between weight fluctuation and CVD.

UR - http://www.scopus.com/inward/record.url?scp=0042820457&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0042820457&partnerID=8YFLogxK

U2 - 10.1038/sj.ijo.0802386

DO - 10.1038/sj.ijo.0802386

M3 - Article

VL - 27

SP - 1059

EP - 1065

JO - International Journal of Obesity

JF - International Journal of Obesity

SN - 0307-0565

IS - 9

ER -