Long-term body weight variability is associated with elevated C-reactive protein independent of current body mass index among Japanese men

K. Tamakoshi, H. Yatsuya, T. Kondo, M. Ishikawa, H. Zhang, C. Murata, R. Otsuka, T. Mabuchi, Y. Hori, S. Zhu, T. Yoshida, H. Toyoshima

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25 Citations (Scopus)

Abstract

OBJECTIVE: To elucidate the effect of long-term weight variability on C-reactive protein (CRP) levels. DESIGN: Cross-sectional study of the circulating CRP. SUBJECTS: A total of 637 Japanese men aged 40-49y in 1997. MEASUREMENTS: Serum CRP levels, body mass index in 1997 (current BMI), the slope of weight on age (weight-slope) representing an individual's weight trend of direction and magnitude, and the root mean square error around the slope of weight on age (weight-RMSE) representing the weight fluctuation magnitude, as calculated by a simple linear regression model in which each value of the subject s five actual weights (aged 20, 25, 30y, five years ago, and current) was a dependent variable and the subject's ages independent variables. RESULTS: After adjustment for age and confounders, including smoking and health status, the odds ratios of elevated CRP (≥0.06 mg/dl) were 1.83 (95% CI: 1.25-2.69), 2.63 (1.69-4.11), and 10.31 (2.17-48.98) for upper normal-weight (BMI: 22-<25 kg/m2), overweight (25-<30), and obese (≥30) persons, respectively, compared with lower normal-weight persons (18.5-<22). Adjusting for age, confounders, and current BMI, weight-slope was positively associated with CRP level especially among subjects with BMI≥25 kg/m 2 (trend P<0.01), and weight-RMSE was positively associated with CRP level particularly among subjects with BMI <25 kg/m2 (trend P<0.05). CONCLUSION: Our results suggest a state of low-grade systemic inflammation not only in overweight and obese persons, but also in normal-weight persons with large weight fluctuation, possibly explaining in part the positive association between weight fluctuation and CVD.

Original languageEnglish
Pages (from-to)1059-1065
Number of pages7
JournalInternational Journal of Obesity
Volume27
Issue number9
DOIs
Publication statusPublished - 01-09-2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

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    Tamakoshi, K., Yatsuya, H., Kondo, T., Ishikawa, M., Zhang, H., Murata, C., Otsuka, R., Mabuchi, T., Hori, Y., Zhu, S., Yoshida, T., & Toyoshima, H. (2003). Long-term body weight variability is associated with elevated C-reactive protein independent of current body mass index among Japanese men. International Journal of Obesity, 27(9), 1059-1065. https://doi.org/10.1038/sj.ijo.0802386