TY - JOUR
T1 - Long-term clinical outcome of patients with recurrent epithelial ovarian carcinoma
T2 - Is it the same for each histological type?
AU - Kajiyama, Hiroaki
AU - Shibata, Kiyosumi
AU - Mizuno, Mika
AU - Umezu, Tomokazu
AU - Suzuki, Shiro
AU - Yamamoto, Eiko
AU - Fujiwara, Sawako
AU - Kawai, Michiyasu
AU - Nagasaka, Tetsuro
AU - Kikkawa, Fumitaka
N1 - Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2012/3
Y1 - 2012/3
N2 - Objective: This study was conducted to estimate the long-term clinical outcome of patients with recurrent ovarian carcinoma (ROC). Methods: Six hundred three patients with ROC were analyzed in this study. The pathological slides were evaluated under central pathological review. The prognostic significances of clinicopathologic factors were evaluated using both univariate and multivariate analysis. Results: The 5-year overall survival (OS) and postrecurrence survival (PRS) rates were 31.1 and 16.9%, respectively. On stratifying to treatment periods, the PRS has been prolonged over the last decade (year ≥2000) compared with before this period (year ≤1999) (P = 0.0002). In contrast, on stratifying to histological types and treatment periods, in both OS and PRS, the prognosis of patients with the nonmucinous/clear-cell histology, including serous, endometrioid, and other histological types, was significantly improved after 2000 compared with before (year ≤1999) (OS, P = 0.0009; PRS, P < 0.0001). In contrast, that of patients with the mucinous/clear-cell histology did not significantly differ regardless of the treatment period (≥2000 vs ≤1999: OS, P = 0.3887; PRS, P = 0.7617). In multivariate analysis, the stage, period of starting initial treatment, histological type, and the treatment-free interval were independent prognostic factors of a poor OS and PRS (OS/ PRS: histological type: mucinous/clear-cell vs nonmucinous/clear-cell: hazard ratio, 1.300/ 1.498; 95% confidence interval [CI], 1.039-1.626/1.197-1.874). Conclusions: Despite the continuous administration of treatment for ROC, survival is poor, and the extent of therapeutic progress differs according to the histological type.
AB - Objective: This study was conducted to estimate the long-term clinical outcome of patients with recurrent ovarian carcinoma (ROC). Methods: Six hundred three patients with ROC were analyzed in this study. The pathological slides were evaluated under central pathological review. The prognostic significances of clinicopathologic factors were evaluated using both univariate and multivariate analysis. Results: The 5-year overall survival (OS) and postrecurrence survival (PRS) rates were 31.1 and 16.9%, respectively. On stratifying to treatment periods, the PRS has been prolonged over the last decade (year ≥2000) compared with before this period (year ≤1999) (P = 0.0002). In contrast, on stratifying to histological types and treatment periods, in both OS and PRS, the prognosis of patients with the nonmucinous/clear-cell histology, including serous, endometrioid, and other histological types, was significantly improved after 2000 compared with before (year ≤1999) (OS, P = 0.0009; PRS, P < 0.0001). In contrast, that of patients with the mucinous/clear-cell histology did not significantly differ regardless of the treatment period (≥2000 vs ≤1999: OS, P = 0.3887; PRS, P = 0.7617). In multivariate analysis, the stage, period of starting initial treatment, histological type, and the treatment-free interval were independent prognostic factors of a poor OS and PRS (OS/ PRS: histological type: mucinous/clear-cell vs nonmucinous/clear-cell: hazard ratio, 1.300/ 1.498; 95% confidence interval [CI], 1.039-1.626/1.197-1.874). Conclusions: Despite the continuous administration of treatment for ROC, survival is poor, and the extent of therapeutic progress differs according to the histological type.
KW - Clear-cell carcinoma
KW - Mucinous adenocarcinoma
KW - Overall survival
KW - Postrecurrence survival
KW - Recurrent ovarian cancer
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U2 - 10.1097/IGC.0b013e31823eed2c
DO - 10.1097/IGC.0b013e31823eed2c
M3 - Article
C2 - 22391762
AN - SCOPUS:84863400544
SN - 1048-891X
VL - 22
SP - 394
EP - 399
JO - International Journal of Gynecological Cancer
JF - International Journal of Gynecological Cancer
IS - 3
ER -