Long-term deprivation of oestrogens by ovariectomy potentiates β-amyloid-induced working memory deficits in rats

Kiyofumi Yamada, Tomoko Tanaka, Li Bo Zou, Kouji Senzaki, Kohji Yano, Takashi Osada, Olariu Ana, Xiuhai Ren, Tsutomu Kameyama, Toshitaka Nabeshima

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Abstract

1. In the present study, we examined whether deprivation of oestrogens by ovariectomy could modify learning and memory deficits caused by a continuous intracerebroventricular (i.c.v.) infusion of amyloid β-peptide (Aβ), the major constituent of senile plaques in AD. 2. Neither long-term (3 months) nor short-term (1 month), deprivation of oestrogens by ovariectomy caused a significant impairment in spatial learning and memory in a water maze and spontaneous alternation behaviour in a Y-maze. 3. A continuous i.c.v. infusion of Aβ-(1-42) caused spatial learning and memory deficits in both ovariectomized and sham-operated rats. 4. The Aβ-induced working memory deficits were significantly potentiated in ovariectomized rats compared with sham-operated rats when mnemonic ability was examined 3 months after ovariectomy. 5. These results suggest that long-term deprivation of oestrogens induced by ovariectomy increases susceptibility to memory deficits produced by Aβ-(1-42) in rats.

Original languageEnglish
Pages (from-to)419-427
Number of pages9
JournalBritish Journal of Pharmacology
Volume128
Issue number2
DOIs
Publication statusPublished - 11-10-1999

All Science Journal Classification (ASJC) codes

  • Pharmacology

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    Yamada, K., Tanaka, T., Zou, L. B., Senzaki, K., Yano, K., Osada, T., Ana, O., Ren, X., Kameyama, T., & Nabeshima, T. (1999). Long-term deprivation of oestrogens by ovariectomy potentiates β-amyloid-induced working memory deficits in rats. British Journal of Pharmacology, 128(2), 419-427. https://doi.org/10.1038/sj.bjp.0702811