TY - JOUR
T1 - Long-term in vivo left ventricular assist device study for 284 days with Gyro PI pump
AU - Ohtsuka, Goro
AU - Nakata, Kin ichi
AU - Yoshikawa, Masaharu
AU - Takano, Tamaki
AU - Glueck, Julia
AU - Sankai, Yoshiyuki
AU - Takami, Yoshiyuki
AU - Mueller, Juergen
AU - Sueoka, Akinori
AU - Letsou, George
AU - Schima, Heinrich
AU - Schmallegger, Helmut
AU - Wolner, Ernst
AU - Koyanagi, Hitoshi
AU - Fujisawa, Akira
AU - Baldwin, John C.
AU - Nosé, Yukihiko
PY - 1999
Y1 - 1999
N2 - A totally implantable centrifugal artificial heart has been developed. The plastic prototype, the Gyro PI 601, passed 2 day hemodynamic tests as a functional total artificial heart (TAH), 2 week screening tests for antithrombogenecity, and a 1 month system feasibility study. Based upon these results, a metallic prototype, the Gyro PI 700 series, was subjected to long- term in vivo left ventricular assist device (LVAD) studies of over 1 month. The Gyro PI 700 series has the same inner dimension and same characteristics of the Gyro PI 601 such as an eccentric inlet port, a double pivot bearing system, and a magnet coupling system. The PI metallic pump is also driven with the Vienna DC brushless motor actuator like the PI 601. The pump- actuator package was implanted in 3 calves in the preperitoneal space, bypassing from the left ventricular (LV) apex to the descending aorta. Case 1 achieved a 284 day survival. Case 2 was euthanized early at 72 postoperative days as a result of the functional obstruction of the inlet port due to the excessive growth of the calf. There was no blood clot inside the pumps of either case. Case 3 is on-going (22 days on July 24, 1998). During these periods, all cases showed no physiological abnormalities. In conclusion, the PI 700 series pump has excellent results as a long-term implantable LVAD.
AB - A totally implantable centrifugal artificial heart has been developed. The plastic prototype, the Gyro PI 601, passed 2 day hemodynamic tests as a functional total artificial heart (TAH), 2 week screening tests for antithrombogenecity, and a 1 month system feasibility study. Based upon these results, a metallic prototype, the Gyro PI 700 series, was subjected to long- term in vivo left ventricular assist device (LVAD) studies of over 1 month. The Gyro PI 700 series has the same inner dimension and same characteristics of the Gyro PI 601 such as an eccentric inlet port, a double pivot bearing system, and a magnet coupling system. The PI metallic pump is also driven with the Vienna DC brushless motor actuator like the PI 601. The pump- actuator package was implanted in 3 calves in the preperitoneal space, bypassing from the left ventricular (LV) apex to the descending aorta. Case 1 achieved a 284 day survival. Case 2 was euthanized early at 72 postoperative days as a result of the functional obstruction of the inlet port due to the excessive growth of the calf. There was no blood clot inside the pumps of either case. Case 3 is on-going (22 days on July 24, 1998). During these periods, all cases showed no physiological abnormalities. In conclusion, the PI 700 series pump has excellent results as a long-term implantable LVAD.
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U2 - 10.1046/j.1525-1594.1999.06391.x
DO - 10.1046/j.1525-1594.1999.06391.x
M3 - Article
C2 - 10392274
AN - SCOPUS:0032974749
SN - 0160-564X
VL - 23
SP - 504
EP - 507
JO - Artificial Organs
JF - Artificial Organs
IS - 6
ER -