Long-term in vivo left ventricular assist device study for 284 days with Gyro PI pump

Goro Ohtsuka, Kin ichi Nakata, Masaharu Yoshikawa, Tamaki Takano, Julia Glueck, Yoshiyuki Sankai, Yoshiyuki Takami, Juergen Mueller, Akinori Sueoka, George Letsou, Heinrich Schima, Helmut Schmallegger, Ernst Wolner, Hitoshi Koyanagi, Akira Fujisawa, John C. Baldwin, Yukihiko Nosé

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

A totally implantable centrifugal artificial heart has been developed. The plastic prototype, the Gyro PI 601, passed 2 day hemodynamic tests as a functional total artificial heart (TAH), 2 week screening tests for antithrombogenecity, and a 1 month system feasibility study. Based upon these results, a metallic prototype, the Gyro PI 700 series, was subjected to long- term in vivo left ventricular assist device (LVAD) studies of over 1 month. The Gyro PI 700 series has the same inner dimension and same characteristics of the Gyro PI 601 such as an eccentric inlet port, a double pivot bearing system, and a magnet coupling system. The PI metallic pump is also driven with the Vienna DC brushless motor actuator like the PI 601. The pump- actuator package was implanted in 3 calves in the preperitoneal space, bypassing from the left ventricular (LV) apex to the descending aorta. Case 1 achieved a 284 day survival. Case 2 was euthanized early at 72 postoperative days as a result of the functional obstruction of the inlet port due to the excessive growth of the calf. There was no blood clot inside the pumps of either case. Case 3 is on-going (22 days on July 24, 1998). During these periods, all cases showed no physiological abnormalities. In conclusion, the PI 700 series pump has excellent results as a long-term implantable LVAD.

Original languageEnglish
Pages (from-to)504-507
Number of pages4
JournalArtificial Organs
Volume23
Issue number6
DOIs
Publication statusPublished - 05-07-1999
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering

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