TY - JOUR
T1 - Long-term in vivo left ventricular assist device study with a titanium centrifugal pump
AU - Ohtsuka, Goro
AU - Nakata, Kin Ichi
AU - Yoshikawa, Masaharu
AU - Mueller, Juergen
AU - Takano, Tamaki
AU - Yamane, Shingo
AU - Gronau, Nicole
AU - Glueck, Julia
AU - Takami, Yoshiyuki
AU - Sueoka, Akinori
AU - Letsou, George
AU - Schima, Heinrich
AU - Schmallegger, Helmut
AU - Wolner, Ernst
AU - Koyanagi, Hitoshi
AU - Fujisawa, Akira
AU - Baldwin, John C.
AU - Nosé, Yukihiko
PY - 1998
Y1 - 1998
N2 - A totally implantable centrifugal artificial heart has been developed. The plastic prototype, Gyro PI 601, passed 2 day hemodynamic tests as a functional total artificial heart, 2 week screening tests for antithrombogenicity, and 1 month system feasibility. Based on these results, a metallic prototype, Gyro PI 702, was subjected to in vivo left ventricular assist device (LVAD) studies. The pump system employed the Gyro PI 702, which has the same inner dimensions and the same characteristics as the Gyro PI 601, including an eccentric inlet port, a double pivot bearing system, and a magnet coupling system. The PI 702 is driven with the Vienna DC brushless motor actuator. For the in vivo LVAD study, the pump actuator package was implanted in the preperitoneal space in two calves, from the left ventricular apex to the descending aorta. Case 1 achieved greater than 9 month survival without any complications, at an average flow rate of 6.6 L/min with 10.2 W input power. Case 2 was killed early due to the excessive growth of the calf, which caused functional obstruction of the inlet port. There was no blood clot inside the pump. During these periods, neither case exhibited any physiologic abnormalities. The PI 702 pump gives excellent results as a long-term implantable LVAD.
AB - A totally implantable centrifugal artificial heart has been developed. The plastic prototype, Gyro PI 601, passed 2 day hemodynamic tests as a functional total artificial heart, 2 week screening tests for antithrombogenicity, and 1 month system feasibility. Based on these results, a metallic prototype, Gyro PI 702, was subjected to in vivo left ventricular assist device (LVAD) studies. The pump system employed the Gyro PI 702, which has the same inner dimensions and the same characteristics as the Gyro PI 601, including an eccentric inlet port, a double pivot bearing system, and a magnet coupling system. The PI 702 is driven with the Vienna DC brushless motor actuator. For the in vivo LVAD study, the pump actuator package was implanted in the preperitoneal space in two calves, from the left ventricular apex to the descending aorta. Case 1 achieved greater than 9 month survival without any complications, at an average flow rate of 6.6 L/min with 10.2 W input power. Case 2 was killed early due to the excessive growth of the calf, which caused functional obstruction of the inlet port. There was no blood clot inside the pump. During these periods, neither case exhibited any physiologic abnormalities. The PI 702 pump gives excellent results as a long-term implantable LVAD.
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U2 - 10.1097/00002480-199809000-00064
DO - 10.1097/00002480-199809000-00064
M3 - Article
C2 - 9804509
AN - SCOPUS:0032169982
SN - 1058-2916
VL - 44
SP - M619-M623
JO - ASAIO Journal
JF - ASAIO Journal
IS - 5
ER -