TY - JOUR
T1 - Long-term outcome of pediatric kidney transplantation
T2 - A single-center experiences
AU - Kuroki, Hiroo
AU - Tasaki, Masayuki
AU - Saito, Kazuhide
AU - Nakagawa, Yuki
AU - Ikezumi, Yohei
AU - Suzuki, Toshiaki
AU - Yamada, Takeshi
AU - Hasegawa, Hiroya
AU - Maruyama, Kaoru
AU - Imai, Naofumi
AU - Takahashi, Kota
AU - Tomita, Yoshihiko
N1 - Publisher Copyright:
© 2018 The Japanese Urological Association
PY - 2018
Y1 - 2018
N2 - (Background) Long-term care is necessary for normal growth and development of pediatric recipients of kidney transplants. We report on our experience with pediatric kidney transplantation (KTx) during the past 19 years. (Methods) We retrospectively analyzed the data from 26 recipients who received KTx between 1996 and 2014 at Niigata University Hospital (one patient underwent two consecutive KTx during the designated period). All recipients were 16 years old or younger at the time of KTx. (Results) The graft survival rates at 1, 5, and 10 years after transplantation were 96%, 96%, and 88%, respectively. Three recipients lost the renal graft function due to graft thrombosis, antibody mediated rejection and steroid resistant rejection. Drug non-adherence was associated with rejection episodes, which led to the increasing of estimated glomerular filtration rate (eGFR) level. In addition, renal graft function was related to the growth after KTx. Eighteen recipients graduated from high school during follow-up periods and 17 recipients obtained employment. (Conclusion) Interventions promoting adherence should be implemented among pediatric recipients and parents to optimize graft survival and growth after KTx. Successful KTx contributed the high rate of social participation and employment after pediatric KTx.
AB - (Background) Long-term care is necessary for normal growth and development of pediatric recipients of kidney transplants. We report on our experience with pediatric kidney transplantation (KTx) during the past 19 years. (Methods) We retrospectively analyzed the data from 26 recipients who received KTx between 1996 and 2014 at Niigata University Hospital (one patient underwent two consecutive KTx during the designated period). All recipients were 16 years old or younger at the time of KTx. (Results) The graft survival rates at 1, 5, and 10 years after transplantation were 96%, 96%, and 88%, respectively. Three recipients lost the renal graft function due to graft thrombosis, antibody mediated rejection and steroid resistant rejection. Drug non-adherence was associated with rejection episodes, which led to the increasing of estimated glomerular filtration rate (eGFR) level. In addition, renal graft function was related to the growth after KTx. Eighteen recipients graduated from high school during follow-up periods and 17 recipients obtained employment. (Conclusion) Interventions promoting adherence should be implemented among pediatric recipients and parents to optimize graft survival and growth after KTx. Successful KTx contributed the high rate of social participation and employment after pediatric KTx.
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U2 - 10.5980/jpnjurol.109.14
DO - 10.5980/jpnjurol.109.14
M3 - Article
C2 - 30662046
AN - SCOPUS:85060157682
SN - 0021-5287
VL - 109
SP - 14
EP - 19
JO - Japanese Journal of Urology
JF - Japanese Journal of Urology
IS - 1
ER -