Long-term outcome of pediatric kidney transplantation: A single-center experiences

Hiroo Kuroki, Masayuki Tasaki, Kazuhide Saito, Yuki Nakagawa, Yohei Ikezumi, Toshiaki Suzuki, Takeshi Yamada, Hiroya Hasegawa, Kaoru Maruyama, Naofumi Imai, Kota Takahashi, Yoshihiko Tomita

Research output: Contribution to journalArticle

Abstract

(Background) Long-term care is necessary for normal growth and development of pediatric recipients of kidney transplants. We report on our experience with pediatric kidney transplantation (KTx) during the past 19 years. (Methods) We retrospectively analyzed the data from 26 recipients who received KTx between 1996 and 2014 at Niigata University Hospital (one patient underwent two consecutive KTx during the designated period). All recipients were 16 years old or younger at the time of KTx. (Results) The graft survival rates at 1, 5, and 10 years after transplantation were 96%, 96%, and 88%, respectively. Three recipients lost the renal graft function due to graft thrombosis, antibody mediated rejection and steroid resistant rejection. Drug non-adherence was associated with rejection episodes, which led to the increasing of estimated glomerular filtration rate (eGFR) level. In addition, renal graft function was related to the growth after KTx. Eighteen recipients graduated from high school during follow-up periods and 17 recipients obtained employment. (Conclusion) Interventions promoting adherence should be implemented among pediatric recipients and parents to optimize graft survival and growth after KTx. Successful KTx contributed the high rate of social participation and employment after pediatric KTx.

Original languageEnglish
Pages (from-to)14-19
Number of pages6
JournalJapanese Journal of Urology
Volume109
Issue number1
DOIs
Publication statusPublished - 01-01-2018

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Kidney Transplantation
Pediatrics
Graft Survival
Transplants
Kidney
Social Participation
Long-Term Care
Growth
Glomerular Filtration Rate
Growth and Development
Thrombosis
Survival Rate
Transplantation
Parents
Steroids
Antibodies
Pharmaceutical Preparations
Rejection (Psychology)

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

Kuroki, Hiroo ; Tasaki, Masayuki ; Saito, Kazuhide ; Nakagawa, Yuki ; Ikezumi, Yohei ; Suzuki, Toshiaki ; Yamada, Takeshi ; Hasegawa, Hiroya ; Maruyama, Kaoru ; Imai, Naofumi ; Takahashi, Kota ; Tomita, Yoshihiko. / Long-term outcome of pediatric kidney transplantation : A single-center experiences. In: Japanese Journal of Urology. 2018 ; Vol. 109, No. 1. pp. 14-19.
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Kuroki, H, Tasaki, M, Saito, K, Nakagawa, Y, Ikezumi, Y, Suzuki, T, Yamada, T, Hasegawa, H, Maruyama, K, Imai, N, Takahashi, K & Tomita, Y 2018, 'Long-term outcome of pediatric kidney transplantation: A single-center experiences', Japanese Journal of Urology, vol. 109, no. 1, pp. 14-19. https://doi.org/10.5980/jpnjurol.109.14

Long-term outcome of pediatric kidney transplantation : A single-center experiences. / Kuroki, Hiroo; Tasaki, Masayuki; Saito, Kazuhide; Nakagawa, Yuki; Ikezumi, Yohei; Suzuki, Toshiaki; Yamada, Takeshi; Hasegawa, Hiroya; Maruyama, Kaoru; Imai, Naofumi; Takahashi, Kota; Tomita, Yoshihiko.

In: Japanese Journal of Urology, Vol. 109, No. 1, 01.01.2018, p. 14-19.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Long-term outcome of pediatric kidney transplantation

T2 - A single-center experiences

AU - Kuroki, Hiroo

AU - Tasaki, Masayuki

AU - Saito, Kazuhide

AU - Nakagawa, Yuki

AU - Ikezumi, Yohei

AU - Suzuki, Toshiaki

AU - Yamada, Takeshi

AU - Hasegawa, Hiroya

AU - Maruyama, Kaoru

AU - Imai, Naofumi

AU - Takahashi, Kota

AU - Tomita, Yoshihiko

PY - 2018/1/1

Y1 - 2018/1/1

N2 - (Background) Long-term care is necessary for normal growth and development of pediatric recipients of kidney transplants. We report on our experience with pediatric kidney transplantation (KTx) during the past 19 years. (Methods) We retrospectively analyzed the data from 26 recipients who received KTx between 1996 and 2014 at Niigata University Hospital (one patient underwent two consecutive KTx during the designated period). All recipients were 16 years old or younger at the time of KTx. (Results) The graft survival rates at 1, 5, and 10 years after transplantation were 96%, 96%, and 88%, respectively. Three recipients lost the renal graft function due to graft thrombosis, antibody mediated rejection and steroid resistant rejection. Drug non-adherence was associated with rejection episodes, which led to the increasing of estimated glomerular filtration rate (eGFR) level. In addition, renal graft function was related to the growth after KTx. Eighteen recipients graduated from high school during follow-up periods and 17 recipients obtained employment. (Conclusion) Interventions promoting adherence should be implemented among pediatric recipients and parents to optimize graft survival and growth after KTx. Successful KTx contributed the high rate of social participation and employment after pediatric KTx.

AB - (Background) Long-term care is necessary for normal growth and development of pediatric recipients of kidney transplants. We report on our experience with pediatric kidney transplantation (KTx) during the past 19 years. (Methods) We retrospectively analyzed the data from 26 recipients who received KTx between 1996 and 2014 at Niigata University Hospital (one patient underwent two consecutive KTx during the designated period). All recipients were 16 years old or younger at the time of KTx. (Results) The graft survival rates at 1, 5, and 10 years after transplantation were 96%, 96%, and 88%, respectively. Three recipients lost the renal graft function due to graft thrombosis, antibody mediated rejection and steroid resistant rejection. Drug non-adherence was associated with rejection episodes, which led to the increasing of estimated glomerular filtration rate (eGFR) level. In addition, renal graft function was related to the growth after KTx. Eighteen recipients graduated from high school during follow-up periods and 17 recipients obtained employment. (Conclusion) Interventions promoting adherence should be implemented among pediatric recipients and parents to optimize graft survival and growth after KTx. Successful KTx contributed the high rate of social participation and employment after pediatric KTx.

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