Long term prognosis of chronic heart failure - Reduced vs preserved left ventricular ejection fraction

Kenji Miyagishima, Shinya Hiramitsu, Hisashi Kimura, Kazumasa Mori, Tomoya Ueda, Shigeru Kato, Yasuchika Kato, Shiho Ishikawa, Masatsugu Iwase, Shin Ichiro Morimoto, Hitoshi Hishida, Yukio Ozaki

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)


Background: Left ventricle diastolic dysfunction is attracting increasing attention of one of the etiologies of chronic heart failure (CHF). Methods and Results: The study sample included 560 patients with CHF who were hospitalized during the 5-year period. They were classified into 2 groups according to the left ventricular ejection fraction (LVEF): reduced group (LVEF<50%, n=431); or preserved group (LVEF≥50%, n=129). The degree of cardiac symptoms did not differ between the 2 groups; however, no difference was found between the 2 groups in the mortality rate (P=0.898), and readmission rates (P=0.674). The results of a multivariate analysis using a Cox proportional hazards model to identify predictors of the prognosis of heart failure revealed no difference in prognosis according to the presence/absence of decreased LVEF, whereas renal dysfunction and anemia were identified as significant prognostic determinants. Also, in the reduced group, the administration of angiotensin-converting enzyme inhibitors (ACE-I) and/or angiotensin II receptor blockers (ARB), β-blockers reduced mortality. In the preserved group, ACE-I and/or ARB administration reduced mortality, whereas β-blockers did not. Conclusion In the present study, the likelihood of LVEF influencing prognosis was considered to be low, with the contribution of non-cardiac factors such as renal function and anemia concluded to be greater.

Original languageEnglish
Pages (from-to)92-99
Number of pages8
JournalCirculation Journal
Issue number1
Publication statusPublished - 2009

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Long term prognosis of chronic heart failure - Reduced vs preserved left ventricular ejection fraction'. Together they form a unique fingerprint.

Cite this